Protein Overview: ITA2_MOUSE

General Information:
Name(s) found:	ITA2_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|S44142 VLA-2 protein homolog - mouse [NCBI NR] gi\|473099\|emb\|CAA82877.1\| VLA-2 homologue [Mus musculus] [NCBI NR] gi\|3183039\|sp\|Q62469.1\|ITA2_MOUSE RecName: Full=Integrin alpha-2; AltName: Full=Platelet membrane glycoprotein Ia; Short=GPIa; AltName: Full=Collagen receptor; AltName: Full=VLA-2 alpha chain; AltName: Full=CD49 antigen-like family member B; AltName: CD_a [NCBI NR] Integrin alpha-2 OS=Mus musculus GN=Itga2 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):13-111583235 Integrin alpha-2 precursor [hmr_yeast5_DM3-1_pombe.fasta] Integrin alpha-2 precursor (Platelet membrane glycoprotein Ia) (GPIa) (Collagen receptor) (VLA-2 alpha chain) (CD49b)gi\|631796\|pir\|\|S44142 VLA-2 protein homolog - mousegi\|473099\|emb\|CAA82877.1\| VLA-2 homologue [Mus musculus] [nrdb_11152004_Chlamydomonas] Integrin alpha-2 precursor [ipi.MOUSE.v3.06.fasta] Tax_Id=10090 Integrin alpha-2 precursor [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta] (NM_008396) integrin alpha 2; VLA-2 receptor, alpha 2 subunit; integrin alpha 2 (Cd49b) [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Integrin alpha-2 precursor (Platelet membrane glycoprotein Ia) (GPIa) (Collagen receptor) (VLA-2 alpha chain) (CD49 antigen-like family member B) (CD49b antigen) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] VLA-2 homologue [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 INTEGRIN ALPHA-2 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Itga2 Integrin alpha-2 [mouse-ipi-250309-contam.fasta] Tax_Id=10090 Gene_Symbol=Itga2 Integrin alpha-2 precursor [ipi.MOUSE_jw_12may08.contam.fasta] Integrin alpha-2 precursor (Platelet membrane glycoprotein Ia) (GPIa) (Collagen receptor) (VLA-2 alpha chain) (CD49b antigen) [nr-271106-contam.fasta] IPI:IPI00126077.1\|SWISS-PROT:Q62469 Tax_Id=10090 Gene_Symbol=Itga2 Integrin alpha-2 [ipi.MOUSE.fasta.20090209] Integrin alpha-2 OS=Mus musculus GN=Itga2 [011711_HMR.fasta]
Organism:	Mus musculus
Length:	1178 amino acids
Gene Ontology:
Cellular Component:	nucleus [UNKNOWN] perinuclear region of cytoplasm [UNKNOWN] focal adhesion [UNKNOWN] membrane [IEA] integral to membrane [IEA] external side of plasma membrane [IDA] cell outer membrane [UNKNOWN] integrin complex [UNKNOWN] cell projection [UNKNOWN] axon [UNKNOWN] axon terminus [UNKNOWN] cell surface [UNKNOWN]
Biological Process:	positive regulation of phagocytosis, engulfment [UNKNOWN] positive regulation of translation [UNKNOWN] positive regulation of inflammatory response [UNKNOWN] positive regulation of positive chemotaxis [UNKNOWN] hypotonic response [UNKNOWN] cell adhesion [IEA] positive regulation of cell adhesion [UNKNOWN] positive regulation of DNA binding [UNKNOWN] skin morphogenesis [UNKNOWN] positive regulation of smooth muscle contraction [UNKNOWN] establishment of protein localization [UNKNOWN] tissue homeostasis [UNKNOWN] positive regulation of smooth muscle cell proliferation [UNKNOWN] positive regulation of leukocyte migration [UNKNOWN] integrin-mediated signaling pathway [IEA] positive regulation of collagen biosynthetic process [UNKNOWN] positive regulation of transmission of nerve impulse [UNKNOWN] detection of mechanical stimulus involved in sensory perception of pain [UNKNOWN] positive regulation of epithelial cell migration [UNKNOWN] positive regulation of smooth muscle cell migration [UNKNOWN] positive regulation of collagen binding [UNKNOWN] positive regulation of alkaline phosphatase activity [UNKNOWN] positive regulation of cell projection organization [UNKNOWN]
Molecular Function:	protein heterodimerization activity [UNKNOWN] integrin binding [UNKNOWN] receptor activity [IEA] protein complex binding [UNKNOWN] laminin binding [UNKNOWN]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGPGQAGGAL LLQLLMLVQG ILNCLAYNVG LPGAKIFSGP SSEQFGYSVQ QLTNPQGNWL  60
   61 LVGSPWSGFP ENRMGDVYKC PVDLPTATCE KLNLQNSASI SNVTEIKTNM SLGLTLTRNP 120
  121 GTGGFLTCGP LWAHQCGNQY YATGICSDVS PDFQFLTSFS PAVQACPSLV DVVVVCDESN 180
  181 SIYPWEAVKN FLVKFVTGLD IGPKKTQVAL IQYANEPRII FNLNDFETKE DMVQATSETR 240
  241 QHGGDLTNTF RAIEFARDYA YSQTSGGRPG ATKVMVVVTD GESHDGSKLK TVIQQCNDDE 300
  301 ILRFGIAVLG YLNRNALDTK NLIKEIKAIA STPTERYFFN VADEAALLEK AGTLGEQIFS 360
  361 IEGTVQGGDN FQMEMAQVGF SADYAPQNDI LMLGAVGAFD WSGTLVQETS HKPVIFPKQA 420
  421 FDQVLQDRNH SSFLGYSVAA ISTEDGVHFV AGAPRANYTG QIVLYSVNKQ GNVTVIQSHR 480
  481 GDQIGSYFGS VLCSVDVDKD TITDVLLVGA PTYMNDLKKE EGKVYLFTIT KGILNQHQFL 540
  541 EGPEGTGNAR FGSAIAALSD INMDGFNDVI VGSPVENENS GAVYIYNGHQ GTIRTKYSQK 600
  601 ILGSNGAFRR HLQFFGRSLD GYGDLNGDSI TDVSIGALGQ VIQLWSQSIA DVAIEALFTP 660
  661 DKITLLNKDA KITLKLCFRA EFRPAGQNNQ VAILFNMTLD ADGHSSRVTS RGVFRENSER 720
  721 FLQKNMVVNE VQKCSEHHIS IQKPSDVVNP LDLRVDISLE NPGTSPALEA YSETVKVFSI 780
  781 PFYKECGSDG ICISDLILDV QQLPAIQTQS FIVSNQNKRL TFSVILKNRG ESAYNTVVLA 840
  841 EFSENLFFAS FSMPVDGTEV TCEVGSSQKS VTCDVGYPAL KSEQQVTFTI NFDFNLQNLQ 900
  901 NQAAINFQAF SESQETNKAD NSVSLTIPLL YDAELHLTRS TNINFYEISS DENAPSVIKS 960
  961 VEDIGPKFIF SLKVTAGSAP VSMALVTIHI PQYTKEKNPL LYLTGIQTDQ AGDISCTAEI1020
 1021 NPLKLPHTAP SVSFKNENFR HTKELDCRTT SCSNITCWLK DLHMKAEYFI NVTTRVWNRT1080
 1081 FAASTFQTVQ LTAAAEIDTH NPQLFVIEEN AVTIPLMIMK PTEKAEVPTG VIIGSIIAGI1140
 1141 LLLLAMTAGL WKLGFFKRQY KKMGQNPDEM DETTELNS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: ITA2_MOUSE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: