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Protein Overview: Dys-PH

General Information:
Name(s) found: Dys-PH / FBpp0110219 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene Dystrophin is referred to in FlyBase by the symbol Dmel\Dys (CG34157, FBgn0260003). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:15286810..15421117. It has the cytological map location 92A5-92A10. There is experimental evidence that it has the molecular function</span>: WW domain binding. There is experimental evidence that it is involved in the biological process</span>: neuromuscular synaptic transmission; imaginal disc-derived wing vein morphogenesis; imaginal disc-derived wing vein specification; regulation of short-term neuronal synaptic plasticity; muscle homeostasis; establishment of cell polarity. 39 alleles are reported. The phenotypes of these alleles are annotated with: posterior crossvein; presynaptic active zone; terminal button. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 3598 amino acids

    Gene Ontology:
    Cellular Component: cytoskeleton [ISS]
    dystrophin-associated glycoprotein complex [IPI][ISS][NAS]
    Biological Process: muscle organ development [ISS]
    muscle cell homeostasis [IMP]
    neuromuscular synaptic transmission [IDA]
    establishment of cell polarity [IMP]
    imaginal disc-derived wing vein morphogenesis [IMP]
    imaginal disc-derived wing vein specification [IMP]
    regulation of short-term neuronal synaptic plasticity [IDA]
    Molecular Function: zinc ion binding [IEA]
    structural constituent of muscle [ISS]
    actin binding [ISS]
    calcium ion binding [IEA]
    structural molecule activity [ISS]
    structural constituent of cytoskeleton [ISS]
    cytoskeletal protein binding [ISS]
    WW domain binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPGILIDER QHIQKKTFTK WINSHLIDTQ CTPVKDLFLD LRDGHRLLAL LSTLTQTNLK  60
   61 PEKGRMRVHH INNLNKVITE IQQHGVKLVN ISSDDIVGGN AKLTLGLIWL IALEFNGQHL 120
  121 VKSHSSNGVE KSLLAWARQY TEPHGLQLND FSSSWSDGRA FLMILDAHVE ELNLQAALQQ 180
  181 HALKRLHLAF DLAHRHFKIE KLLDAEDVHT HKPDNKSIQM YVMCLYHAME SMRTRQQEQE 240
  241 QDEGQDQDPG RVPCTSITDL DEVPLDNDQT SLGLYTSDSA GSMEQRSSGE LKTHSMRPLS 300
  301 TATNASVEIS GYQSALEAVL TLLLEDEQLL SQNLPDPQDF QTAKLQFHEN ESFMLKLTEH 360
  361 QEYVGEALEE GSNLINESQK AGAGLSQEDQ NEVRQQMVLL NERWETLRLR ALDVQAKILM 420
  421 RLAEFQKQKL EQLRQFLTSV EDRISHMSDI GPTLEEAEKQ LLEAQKLKAD LSEQQELVDS 480
  481 LSSMVVIVND TSGNFNDLED RLSALGERWS HVVKWSDLRK EKLQQYKCIS RWLDAREQDL 540
  541 KLMESRDVTD VGGITQRINE LNYCAKDLLE LQRYLIDLRQ MVAATLQDGD DKGERVLIQL 600
  601 ESYEDRLDAL KQIVEVQTVR IETKGFNFGR DRASYDDSRV VRPEGWVDYQ MIIRFGEDDS 660
  661 QEDDDEHDLA SKKRKLRNAD NFNALENHIM EHFGYVQEVE QKLQQLQRQS LRQQCELLKE 720
  721 LQAENSRRCG TLPELKKLYE VCELEDPSRN LLLEETHIKQ LEQRYANLSQ KLSSQQSESH 780
  781 TLLAKEKYYN SLTGFKLVLA DSRDWYKQHA GSASGNELEQ RLSHMESLAS EISEAKTATE 840
  841 ELDDNLIEWK QDFGLFYDSW HDMKQALQAL IQQRGGESLS RQLKQIQDFV TKVSNQKVRV 900
  901 SNLEVMQEQQ HFLNQLLDEM ESLRLTYDNI PKHLIGEELQ TAWNRLPEQL NERVIKQTTA 960
  961 IENLNHFAAE YNAIIAMLRS AADSKLNGSD GASSQDLRKL EIDVISARNF SEILIKEAEP1020
 1021 AQKESLQSQI RALNTLYDQV EQVHREKKEQ QTVLQSHIDL IQLRLKETDQ WLTDLESNTP1080
 1081 KSGISDIVNS NELFQSKSRF QTLKETCERE TTQFRDLNER GGELLLQMDE LQDQDRESRY1140
 1141 GSLAKQFTRI NARWTEVTEL VYAKTALLEH ISTQLGEFKK FMVSETGYLD KLENKIRNTP1200
 1201 ENAADAEEIM EELDDLENVL RSHSEEWLDK IQEIGNELID NEFMADSIRR DIDETVQRWT1260
 1261 QLQQQAKKRT ELLEQKVSEA EQSEKCIVQF EKWLTRVDDI LSDHLDNDVT IVDQPEEFQR1320
 1321 LAHEFVANEK NFKEISELID EHTRNGKVGA ANRLQEQLNL MEVRFKYCQA KLSKCTAIQH1380
 1381 SYESRLNRAY TDLRNVERST EVVDVASAGP NTVQTQYQKC LQIYRTLSEI KSEIESTIKT1440
 1441 GRRVCEDRYT KSPKQLSQRI DALKHLYNTL GENVTQSKAT LERLLTLARQ LEECFDSADN1500
 1501 LIRRFESPQE VHDRNSILLE FEDVLRRCED HYNEYNKSCD QSCMVETRQR IDGLKATYHK1560
 1561 LTSADIIKRL TEMKTTLQNL DNISLETLRA MEHDLKEINV PSNPEIEKLQ QQVIAIVVDV1620
 1621 LKTRFNEATT LAARNTSSPD NDDTEIVVVS DTVRQRRART PQSGESPSSA HTSSSESPTK1680
 1681 GVENSPGAVG DQVMPDLLPP QTFRLAESST LFSQISLNPQ KVTNTPPPKP AKTKRKAPSS1740
 1741 PAQVVEIRVK NIQNDKMSVQ NIDLEPQQGE IVDTVNILES VEPFVPEYVE TVQIVDLSED1800
 1801 SDSSVRVDSQ GKEMRRSKSK HSLNETPLPK VSDNDEDSAE QEEDLLRPSA ENTSTPFLRV1860
 1861 EKRRISFDEK RKRVANERDI LRDSEEEEPK TPDTPRAAQV SKPKRWRQLQ PEMDALEPES1920
 1921 PGRDSFYSPD KESGFDAEPL VFSDDEDIPR FSLEMTSTID SDSDTSRIMT PSTKNPNPFL1980
 1981 SKVLESLSSP VDDSNVTLKS PISEEQPQNL DDRVREFDKQ AKQMIYKLKL TKAKIEQCHE2040
 2041 SEAEDLRLLI APDAATLISQ GDSLVLETHG RQGSISRLVM RTQIILREQF REVQQARSKT2100
 2101 SGSGAPAPPL DSVNIEELVT KGLRRINVLI EKTVDLKSST DLEKRMEDIN ERHDDLQVIV2160
 2161 SAIGKNAQMP KVTPLMMNEI EKTKNNLIAH ADSIELSLTE LRNGPRISNG KERPDASSAA2220
 2221 TMSCRSEYNN EPSGTGALAG SFDKSVLQIS DWLTWEQNMI KIQSVLVDDG DAVRLAIEKQ2280
 2281 EKVLRELKMK KPQLNELVHT AEVLKGDVKR QQLQEKELKQ FSLAPHCSAD LDYMRCCLKV2340
 2341 TRLREHWDET SQCVLQRAAQ LKNMLSDSQR FEAKRLELEK WLARMEQRAE RMGTIATTAD2400
 2401 ILEAQQKEQK SFHAELHQNK QHFDIFNELT QKLIAVYPND DTTRIKKMTE VINQRYANLN2460
 2461 SGVINRGKQL HAAVHSLQSF DRAMDQFLAF LSETETLCEN AESDIERNPL MFKDLQSEIE2520
 2521 THRVVYDRLD GTGRKLLGSL TSQEDAVMLQ RRLDEMNQRW NNLKSKSIAI RNRLESNSEH2580
 2581 WNALLLSLRE LTEWVIRKDT ELSTLGLGPV RGDAVSLQKQ LDDHKAFRRQ LEDKRPIVES2640
 2641 NLTSGRQYIA NEAAVSDTSD TEANHDSDSR YMSAEEQSRE LTRSIRREVG KLSEQWNNLI2700
 2701 DRSDNWKHRL DEYMTKMRQF QKILEDLSSR VALAEQTKTS WLPPSSVGEA NEQMQQLQRL2760
 2761 RDKMTTASAL LDDCNEQQSF FTANQVLVPT PCLSKLEDLN TRMKLLQIAM DERQKVLCQA2820
 2821 GAQQTHENGD DGRTTSNSGT IGPLPNLGQS VKPPWERATT AANVPYYIDH ERETTHWDHP2880
 2881 EMIELMKGLA DLNEIRFSAY RTAMKLRSVQ KRLALDRISM STACESFDRH GLRAQNDKLI2940
 2941 DIPDMTTVLH SLYVTIDKID LTLMLDLAIN WILNVYDSQR TGQIRVLSFK VGLVLLCKGH3000
 3001 LEEKYRYLFR LVADTDRRAD QRRLGLLLHD CIQVPRQLGE VAAFGGSNIE PSVRSCLEQA3060
 3061 GISQEAIDGN QDISIELQHF LGWLQHEPQS LVWLPVLHRL AAAEAAKHQA KCNICKEYPI3120
 3121 VGFRYRCLKC FNFDMCQKCF FFGRNAKNHK LTHPMHEYCT TTTSTEDVRD FTRALKNKFK3180
 3181 SRKYFKKHPR VGYLPVQSVL EGDALESPAP SPQHTTHQLQ NDMHSRLEMY ASRLAQVEYG3240
 3241 GTGSNSTPDS DDEHQLIAQY CQALPGTSNG SAPKSPVQVM AAMDAEQREE LEAIIRDLEE3300
 3301 ENANLQAEYQ QLCSKEQSGM PEDSNGMQHS SSSMTGLSGQ GEQGQDMMAE AKLLRQHKGR3360
 3361 LEARMQILED HNRQLEAQLQ RLRQLLDEPN GGGSSATSSG LPSAPGSALN SKPNTLQTRS3420
 3421 VTASQLNTDS PAKMNQQNGH YEHNSKGIML PGMNSEIQQQ HAQLASLAAK HHQHQLSGAL3480
 3481 NALHQQQQQQ LQQQPPQQQR SMMTGNGGMD ISGGMQTSGG YLGDDGRPPP PPHSSLMQQQ3540
 3541 HQQHLNENSS GLVTVITEQE LESINDDLED SSSSNTTNTT TTTTTTATTE KTCVELQK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle