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Protein Overview: Dscam-PAU

General Information:
Name(s) found: Dscam-PAU / FBpp0110361 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2018 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    dendrite [IDA]
    neuronal cell body [IDA]
    axon [IDA]
    Biological Process: mushroom body development [IMP]
    dendrite self-avoidance [IDA][IMP]
    phagocytosis [IMP]
    axon guidance [IGI][IMP][TAS]
    peripheral nervous system development [IMP]
    neuron development [IMP]
    central nervous system morphogenesis [IMP]
    axonal fasciculation [IMP]
    axon extension involved in axon guidance [IMP]
    Molecular Function: protein binding [IDA]
    protein homodimerization activity [IPI]
    axon guidance receptor activity [IMP][NAS]
    bacterial cell surface binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVIQS YESEADNEYV IRGNSVVMKC EIPSYVADFV FVDLWLDSEG 180
  181 RNYYPNNAAE TDGKYLVLPS GELHIREVGP EDGYKSYQCR TKHRLTGETR LSATKGRLVI 240
  241 TEPISAKAPV LAVDTKWSGI ERHRDMDIVL LCPAQAYPVP ISRWYKFIEG TTRKQAVVLN 300
  301 DRVKQVSGTL IIKDAVVEDS GKYLCVVNNS VGGESVETVL TVTAPLSAKI DPPTQTVDFG 360
  361 RPAVFTCQYT GNPIKTVSWM KDGKAIGHSE PVLRIESVKK EDKGMYQCFV RNDQESAEAS 420
  421 AELKLGGRFD PPVIRQAFQE ETMEPGPSVF LKCVAGGNPT PEISWELDGK KIANNDRYQV 480
  481 GQYVTVNGDV VSYLNITSVH ANDGGLYKCI AKSKVGVAEH SAKLNVYGLP YIRQMEKKAI 540
  541 VAGETLIVTC PVAGYPIDSI VWERDNRALP INRKQKVFPN GTLIIENVER NSDQATYTCV 600
  601 AKNQEGYSAR GSLEVQVMVL PQVVPFDFGE ESINELDMVS ASCTVNKGDL PVDIYWTKNG 660
  661 GRVYTNDGLI VTRNSQRLSV LSIESVRARH AGNYSCVATN NAGAITQSAM LAVNVPPRWI 720
  721 LEPTDKAFAQ GSDAKVECKA DGFPKPQVTW KKAVGDTPGE YKDLKKSDNI RVEEGTLHVD 780
  781 NIQKTNEGYY LCEAINGIGS GLSAVIMISV QAPPEFTEKL RNQTARRGEP AVLQCEAKGE 840
  841 KPIGILWNMN NMRLDPKNDN RYTIREEILS TGVMSSLSIK RTERSDSALF TCVATNAFGS 900
  901 DDASINMIVQ EVPEMPYALK VLDKSGRSVQ LSWAQPYDGN SPLDRYIIEF KRSRASWSEI 960
  961 DRVIVPGHTT EAQVQKLSPA TTYNIRIVAE NAIGTSQSSE AVTIITAEEA PSGKPQNIKV1020
 1021 EPVNQTTMRV TWKPPPRTEW NGEILGYYVG YKLSNTNSSY VFETINFITE EGKEHNLELQ1080
 1081 NLRVYTQYSV VIQAFNKIGA GPLSEEEKQF TAEGTPSQPP SDTACTTLTS QTIRVGWVSP1140
 1141 PLESANGVIK TYKVVYAPSD EWYDETKRHY KKTASSDTVL HGLKKYTNYT MQVLATTAGG1200
 1201 DGVRSVPIHC QTEPDVPEAP TDVKALVMGN AAILVSWRPP AQPNGIITQY TVYSKAEGAE1260
 1261 TETKTQKVPH YQMSFEATEL EKNKPYEFWV TASTTIGEGQ QSKSIVAMPS DQVPAKIASF1320
 1321 DDTFTATFKE DAKMPCLAVG APQPEITWKI KGVEFSANDR MRVLPDGSLL IKSVNRQDAG1380
 1381 DYSCHAENSI AKDSITHKLI VLAPPQSPHV TLSATTTDAL TVKLKPHEGD TAPLHGYTLH1440
 1441 YKPEFGEWET SEVSVDSQKH NIEGLLCGSR YQVYATGFNN IGAGEASDIL NTRTKGQKPK1500
 1501 LPEKPRFIEV SSNSVSLHFK AWKDGGCPMS HFVVESKKRD QIEWNQISNN VKPDNNYVVL1560
 1561 DLEPATWYNL RITAHNSAGF TVAEYDFATL TVTGGTIAPS RDLPELSAED TIRIILSNLN1620
 1621 LVVPVVAALL VIIIAIIVIC ILRSKGNHHK DDVVYNQTMG PGATLDKRRP DLRDELGYIA1680
 1681 PPNRKLPPVP GSNYNTCDRI KRGRGGLRSN HSTWDPRRNP NLYEELKAPP VPMHGNHYGH1740
 1741 AHGNAECHYR HPGMEDEICP YATFHLLGFR EEMDPTKAMN FQTFPHQNGH AGPVPGHAGT1800
 1801 MLPPGHPGHV HSRSGSQSMP RANRYQRKNS QGGQSSIYTP APEYDDPANC AEEDQYRRYT1860
 1861 RVNSQGGSLY SGPGPEYDDP ANCAPEEDQY GSQYGGPYGQ PYDHYGSRGS MGRRSIGSAR1920
 1921 NPGNGSPEPP PPPPRNHDMS NSSFNDSKES NEISEAECDR DHGPRGNYGA VKRSPQPKDQ1980
 1981 RTTEEMRKLI ERNETGPKQL QLQQANGAGF TAYDTMAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..138] PSI-BLAST 76.0 No description for 2v5rA was found.
    2 View Details [139..819] PSI-BLAST 54.522879 Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
    3 View Details [820..897] PSI-BLAST 38.154902 No description for 2nziA was found.
    4 View Details [898..1006] FFAS03 6.02 The eighth FN3 domain of human sidekick-2
    5 View Details [1007..1111] PSI-BLAST 11.0 Solution structure of the second FNIII domain of DSCAML1 protein
    6 View Details [1112..1213] PSI-BLAST 10.0 No description for 2dlhA was found.
    7 View Details [1214..1708] PSI-BLAST 26.045757 No description for 2v5yA was found.
    8 View Details [1709..1772] deduced N/A No confident structure predictions are available.
    9 View Details [1773..2018] MSA 1.155993 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • pattern binding
    		•  0.193336192164784 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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