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Protein Overview: Dscam-PAZ

General Information:
Name(s) found: Dscam-PAZ / FBpp0110366 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2035 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    dendrite [IDA]
    neuronal cell body [IDA]
    axon [IDA]
    Biological Process: mushroom body development [IMP]
    dendrite self-avoidance [IDA][IMP]
    phagocytosis [IMP]
    axon guidance [IGI][IMP][TAS]
    peripheral nervous system development [IMP]
    neuron development [IMP]
    central nervous system morphogenesis [IMP]
    axonal fasciculation [IMP]
    axon extension involved in axon guidance [IMP]
    Molecular Function: protein binding [IDA]
    protein homodimerization activity [IPI]
    axon guidance receptor activity [IMP][NAS]
    bacterial cell surface binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVPQS YTVNVMDESI LRGNSAILKC HIPSFVADFI VVDSWVEDEE 180
  181 RVIYPQEDIA ESDGKYLVLP SGELHIREVG PEDGYKSYQC RTKHRLTGET RLSATKGRLV 240
  241 ITEPIGSVSP KISNSDDLKH VKVKRLLSLS LLCPAQAYPQ PISRWYKFIE GTTRKQAVVL 300
  301 NDRVKQVSGT LIIKDAVVED SGKYLCVVNN SVGGESVETV LTVTAPLSAK IDPPTQTVDF 360
  361 GRPAVFTCQY TGNPIKTVSW MKDGKAIGHS EPVLRIESVK KEDKGMYQCF VRNDQESAEA 420
  421 SAELKLGGRF DPPVIRQAFQ EETMEPGPSV FLKCVAGGNP TPEISWELDG KKIANNDRYQ 480
  481 VGQYVTVNGD VVSYLNITSV HANDGGLYKC IAKSKVGVAE HSAKLNVYGL PYIRQMEKKA 540
  541 IVAGETLIVT CPVAGYPIDS IVWERDNRAL PINRKQKVFP NGTLIIENVE RNSDQATYTC 600
  601 VAKNQEGYSA RGSLEVQVMV APKIAPFDFG DEPSNFGESA SVQCLVTSGD FPVSFAWLFN 660
  661 GREINENVYD VSMVKLGKKI SALSIDIVRD HHAGNYTCVA VNRATSVNFT AELVVNVPPR 720
  721 WILEPTDKAF AQGSDAKVEC KADGFPKPQV TWKKAVGDTP GEYKDLKKSD NIRVEEGTLH 780
  781 VDNIQKTNEG YYLCEAINGI GSGLSAVIMI SVQAPPEFTE KLRNQTARRG EPAVLQCEAK 840
  841 GEKPIGILWN MNNMRLDPKN DNRYTIREEI LSTGVMSSLS IKRTERSDSA LFTCVATNAF 900
  901 GSDDASINMI VQEVPEMPYA LKVLDKSGRS VQLSWAQPYD GNSPLDRYII EFKRSRASWS 960
  961 EIDRVIVPGH TTEAQVQKLS PATTYNIRIV AENAIGTSQS SEAVTIITAE EAPSGKPQNI1020
 1021 KVEPVNQTTM RVTWKPPPRT EWNGEILGYY VGYKLSNTNS SYVFETINFI TEEGKEHNLE1080
 1081 LQNLRVYTQY SVVIQAFNKI GAGPLSEEEK QFTAEGTPSQ PPSDTACTTL TSQTIRVGWV1140
 1141 SPPLESANGV IKTYKVVYAP SDEWYDETKR HYKKTASSDT VLHGLKKYTN YTMQVLATTA1200
 1201 GGDGVRSVPI HCQTEPDVPE APTDVKALVM GNAAILVSWR PPAQPNGIIT QYTVYSKAEG1260
 1261 AETETKTQKV PHYQMSFEAT ELEKNKPYEF WVTASTTIGE GQQSKSIVAM PSDQVPAKIA1320
 1321 SFDDTFTATF KEDAKMPCLA VGAPQPEITW KIKGVEFSAN DRMRVLPDGS LLIKSVNRQD1380
 1381 AGDYSCHAEN SIAKDSITHK LIVLAPPQSP HVTLSATTTD ALTVKLKPHE GDTAPLHGYT1440
 1441 LHYKPEFGEW ETSEVSVDSQ KHNIEGLLCG SRYQVYATGF NNIGAGEASD ILNTRTKGQK1500
 1501 PKLPEKPRFI EVSSNSVSLH FKAWKDGGCP MSHFVVESKK RDQIEWNQIS NNVKPDNNYV1560
 1561 VLDLEPATWY NLRITAHNSA GFTVAEYDFA TLTVTGGTIA PLDDGSGHGN VHTRIRLPAW1620
 1621 MPEWLDLNFM VPLIATVVVV AVGICVVCVA LSRRRADDMR GGQKDVYYDV VYNQTMGPGA1680
 1681 TLDKRRPDLR DELGYIAPPN RKLPPVPGSN YNTCDRIKRG RGGLRSNHST WDPRRNPNLY1740
 1741 EELKAPPVPM HGNHYGHAHG NAECHYRHPG MEDEICPYAT FHLLGFREEM DPTKAMNFQT1800
 1801 FPHQNGHAGP VPGHAGTMLP PGHPGHVHSR SGSQSMPRAN RYQRKNSQGG QSSIYTPAPE1860
 1861 YDDPANCAEE DQYRRYTRVN SQGGSLYSGP GPEYDDPANC APEEDQYGSQ YGGPYGQPYD1920
 1921 HYGSRGSMGR RSIGSARNPG NGSPEPPPPP PRNHDMSNSS FNDSKESNEI SEAECDRDHG1980
 1981 PRGNYGAVKR SPQPKDQRTT EEMRKLIERN ETGPKQLQLQ QANGAGFTAY DTMAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..256] PSI-BLAST 82.0 No description for 2v5sA was found.
    2 View Details [257..900] PSI-BLAST 59.522879 Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
    3 View Details [901..1373] PSI-BLAST 30.0 No description for 2v5yA was found.
    4 View Details [1374..1604] PSI-BLAST 24.09691 FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10
    5 View Details [1605..1832] deduced N/A No confident structure predictions are available.
    6 View Details [1833..2035] MSA 2.121994 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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