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Protein Overview: Dscam-PBD

General Information:
Name(s) found: Dscam-PBD / FBpp0110370 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2030 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    dendrite [IDA]
    neuronal cell body [IDA]
    axon [IDA]
    Biological Process: mushroom body development [IMP]
    dendrite self-avoidance [IDA][IMP]
    phagocytosis [IMP]
    axon guidance [IGI][IMP][TAS]
    peripheral nervous system development [IMP]
    neuron development [IMP]
    central nervous system morphogenesis [IMP]
    axonal fasciculation [IMP]
    axon extension involved in axon guidance [IMP]
    Molecular Function: protein binding [IDA]
    protein homodimerization activity [IPI]
    axon guidance receptor activity [IMP][NAS]
    bacterial cell surface binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVNQF YEAEIMTEYV IRGNAAVLKC SIPSFVADFV RVESWIDDEG 180
  181 NVLSFSDNYD GKYLVLPSGE LHIREVGPED GYKSYQCRTK HRLTGETRLS ATKGRLVITE 240
  241 PVGRVSPKFP NTLTSSSFTG DEGSSQTLLC PAQAYPAPLF RWYKFIEGTT RKQAVVLNDR 300
  301 VKQVSGTLII KDAVVEDSGK YLCVVNNSVG GESVETVLTV TAPLSAKIDP PTQTVDFGRP 360
  361 AVFTCQYTGN PIKTVSWMKD GKAIGHSEPV LRIESVKKED KGMYQCFVRN DQESAEASAE 420
  421 LKLGGRFDPP VIRQAFQEET MEPGPSVFLK CVAGGNPTPE ISWELDGKKI ANNDRYQVGQ 480
  481 YVTVNGDVVS YLNITSVHAN DGGLYKCIAK SKVGVAEHSA KLNVYGLPYI RQMEKKAIVA 540
  541 GETLIVTCPV AGYPIDSIVW ERDNRALPIN RKQKVFPNGT LIIENVERNS DQATYTCVAK 600
  601 NQEGYSARGS LEVQVMVPPK LAPLPVNSPL YVGDYYQLTC AVVHGDAPFN ITWYYNNEPA 660
  661 GDLAGVTILM HGRRSSSLNI ESVGGDHAGN YTCKGANRAG ETTAETHLSV KVPPRWILEP 720
  721 TDKAFAQGSD AKVECKADGF PKPQVTWKKA VGDTPGEYKD LKKSDNIRVE EGTLHVDNIQ 780
  781 KTNEGYYLCE AINGIGSGLS AVIMISVQAP PEFTEKLRNQ TARRGEPAVL QCEAKGEKPI 840
  841 GILWNMNNMR LDPKNDNRYT IREEILSTGV MSSLSIKRTE RSDSALFTCV ATNAFGSDDA 900
  901 SINMIVQEVP EMPYALKVLD KSGRSVQLSW AQPYDGNSPL DRYIIEFKRS RASWSEIDRV 960
  961 IVPGHTTEAQ VQKLSPATTY NIRIVAENAI GTSQSSEAVT IITAEEAPSG KPQNIKVEPV1020
 1021 NQTTMRVTWK PPPRTEWNGE ILGYYVGYKL SNTNSSYVFE TINFITEEGK EHNLELQNLR1080
 1081 VYTQYSVVIQ AFNKIGAGPL SEEEKQFTAE GTPSQPPSDT ACTTLTSQTI RVGWVSPPLE1140
 1141 SANGVIKTYK VVYAPSDEWY DETKRHYKKT ASSDTVLHGL KKYTNYTMQV LATTAGGDGV1200
 1201 RSVPIHCQTE PDVPEAPTDV KALVMGNAAI LVSWRPPAQP NGIITQYTVY SKAEGAETET1260
 1261 KTQKVPHYQM SFEATELEKN KPYEFWVTAS TTIGEGQQSK SIVAMPSDQV PAKIASFDDT1320
 1321 FTATFKEDAK MPCLAVGAPQ PEITWKIKGV EFSANDRMRV LPDGSLLIKS VNRQDAGDYS1380
 1381 CHAENSIAKD SITHKLIVLA PPQSPHVTLS ATTTDALTVK LKPHEGDTAP LHGYTLHYKP1440
 1441 EFGEWETSEV SVDSQKHNIE GLLCGSRYQV YATGFNNIGA GEASDILNTR TKGQKPKLPE1500
 1501 KPRFIEVSSN SVSLHFKAWK DGGCPMSHFV VESKKRDQIE WNQISNNVKP DNNYVVLDLE1560
 1561 PATWYNLRIT AHNSAGFTVA EYDFATLTVT GGTIAPLDDG SGHGNVHTRI RLPAWMPEWL1620
 1621 DLNFMVPLIA TVVVVAVGIC VVCVALSRRR ADDMRGGQKD VYYDVVYNQT MGPGATLDKR1680
 1681 RPDLRDELGY IAPPNRKLPP VPGSNYNTCD RIKRGRGGLR SNHSTWDPRR NPNLYEELKA1740
 1741 PPVPMHGNHY GHAHGNAECH YRHPGMEDEI CPYATFHLLG FREEMDPTKA MNFQTFPHQN1800
 1801 GHAGPVPGHA GTMLPPGHPG HVHSRSGSQS MPRANRYQRK NSQGGQSSIY TPAPEYDDPA1860
 1861 NCAEEDQYRR YTRVNSQGGS LYSGPGPEYD DPANCAPEED QYGSQYGGPY GQPYDHYGSR1920
 1921 GSMGRRSIGS ARNPGNGSPE PPPPPPRNHD MSNSSFNDSK ESNEISEAEC DRDHGPRGNY1980
 1981 GAVKRSPQPK DQRTTEEMRK LIERNETGPK QLQLQQANGA GFTAYDTMAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..138] PSI-BLAST 82.69897 No description for 2v5sA was found.
    2 View Details [139..246] PSI-BLAST 21.69897 No description for 2ec8A was found.
    3 View Details [247..908] PSI-BLAST 56.221849 Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
    4 View Details [909..1368] PSI-BLAST 28.522879 No description for 2v5yA was found.
    5 View Details [1369..1591] PSI-BLAST 26.221849 FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10
    6 View Details [1592..1800] deduced N/A No confident structure predictions are available.
    7 View Details [1801..2030] MSA 1.128993 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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