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Protein Overview: HMGCR

General Information:
Name(s) found: HMGCR [HGNC (HUGO)]
Description(s) found:
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  • pir||RDHUE hydroxymethylglutaryl-CoA reductase (NADPH2) (EC 1.1.1.34) - human [NCBI NR]
  • gi|4557643|ref|NP_000850.1| 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 1 [Homo sapiens] [NCBI NR]
  • gi|32165622|gb|AAP72015.1| 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Homo sapiens] [NCBI NR]
  • gi|306865|gb|AAA52679.1| 3-hydroxy-3-methylglutaryl coenzyme A reductase [Homo sapiens] [NCBI NR]
  • gi|123343|sp|P04035.1|HMDH_HUMAN RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase; Short=HMG-CoA reductase [NCBI NR]
  • gi|119616161|gb|EAW95755.1| 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119616160|gb|EAW95754.1| 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|10644584|gb|AAG21343.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Homo sapiens] [NCBI NR]
  • 3-hydroxy-3-methylglutaryl-CoA reductase [HGNC (HUGO)]
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Homo sapiens GN=HMGCR PE=1 SV=1 [Swiss-Prot]
  • Splice isoform 1 of P04035 [hmr_yeast5_DM3-1_pombe.fasta]
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [HMR_022704.fasta]
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Homo sapiens]gi|32165622|gb|AAP72015.1| 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Homo sapiens]gi|65934|pir||RDHUE hydroxymethylglutaryl-CoA reductase (NADPH2) (EC 1.1.1.34) - humangi|10644584|gb| [nrdb_11152004_Chlamydomonas]
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of 3-hydroxy-3-methylglutaryl-coenzyme A reductase [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_000859) 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • 3-hydroxy-3-methylglutaryl coenzyme A reductase [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of 3-hydroxy-3-methylglutaryl-coenzyme A reductase [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase; Short=HMG-CoA reductase [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=HMGCR Isoform 1 of 3-hydroxy-3-methylglutaryl-coenzyme A reductase [human-ipi-250309-contam.fasta]
  • IPI:IPI00021770.1|SWISS-PROT:P04035-1|TREMBL:A8KA27;B2R649|ENSEMBL:ENSP00000287936|REFSEQ:NP_000850|H-INV:HIT000194098|VEGA:OTTHUMP00000128250 Tax_Id=9606 Gene_Symbol=HMGCR Isoform 1 of 3-hydroxy-3-methylglutaryl-coenzyme A reductase [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=HMGCR Isoform 1 of 3-hydroxy-3-methylglutaryl-coenzyme A reductase ENSG00000113161 IPI00021770 IPI00221382 [drosphohumanreversed.fasta]
  • P04035;Q8N190; RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Homo sapiens GN=HMGCR [011711_HMR.fasta]
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase n=27 Tax=Tetrapoda RepID=HMDH_HUMAN [UniProt_Xenopus_laevis_01-01-2011_reversed.fasta]
  • GeneSymbol=HMGCR Synonyms=LDLCQ3 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00021770.1|SWISS-PROT:P04035-1|TREMBL:A8KA27;B2R649|ENSEMBL:ENSP00000287936;ENSP00000426745|REFSEQ:NP_000850|H-INV:HIT000194098|VEGA:OTTHUMP00000128250;OTTHUMP00000222062 Tax_Id=9606 Gene_Symbol=HMGCR Isoform 1 of 3-hydroxy-3-methylglutaryl-coenzyme A reductase [ipi.HUMAN.20110912.fasta]
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase GN=HMGCR [Doctor+uniprot-HUMAN-120911.fasta]
  • 3-hydroxy-3-methylglutaryl coenzyme A reductase OS=Homo sapiens GN=HMGCR PE=3 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 888 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC PKFEEDVLSS  60
   61 DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI FSSFVFSTVV IHFLDKELTG 120
  121 LNEALPFFLL LIDLSRASTL AKFALSSNSQ DEVRENIARG MAILGPTFTL DALVECLVIG 180
  181 VGTMSGVRQL EIMCCFGCMS VLANYFVFMT FFPACVSLVL ELSRESREGR PIWQLSHFAR 240
  241 VLEEEENKPN PVTQRVKMIM SLGLVLVHAH SRWIADPSPQ NSTADTSKVS LGLDENVSKR 300
  301 IEPSVSLWQF YLSKMISMDI EQVITLSLAL LLAVKYIFFE QTETESTLSL KNPITSPVVT 360
  361 QKKVPDNCCR REPMLVRNNQ KCDSVEEETG INRERKVEVI KPLVAETDTP NRATFVVGNS 420
  421 SLLDTSSVLV TQEPEIELPR EPRPNEECLQ ILGNAEKGAK FLSDAEIIQL VNAKHIPAYK 480
  481 LETLMETHER GVSIRRQLLS KKLSEPSSLQ YLPYRDYNYS LVMGACCENV IGYMPIPVGV 540
  541 AGPLCLDEKE FQVPMATTEG CLVASTNRGC RAIGLGGGAS SRVLADGMTR GPVVRLPRAC 600
  601 DSAEVKAWLE TSEGFAVIKE AFDSTSRFAR LQKLHTSIAG RNLYIRFQSR SGDAMGMNMI 660
  661 SKGTEKALSK LHEYFPEMQI LAVSGNYCTD KKPAAINWIE GRGKSVVCEA VIPAKVVREV 720
  721 LKTTTEAMIE VNINKNLVGS AMAGSIGGYN AHAANIVTAI YIACGQDAAQ NVGSSNCITL 780
  781 MEASGPTNED LYISCTMPSI EIGTVGGGTN LLPQQACLQM LGVQGACKDN PGENARQLAR 840
  841 IVCGTVMAGE LSLMAALAAG HLVKSHMIHN RSKINLQDLQ GACTKKTA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..513] PSI-BLAST 71.522879 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains; Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains; Multidrug efflux transporter AcrB transmembrane domain
    2 View Details [514..888] PSI-BLAST 1000.0 NAD-binding domain of HMG-CoA reductase; Substrate-binding domain of HMG-CoA reductase


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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