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Protein Overview: CHD8_RAT

General Information:
Name(s) found: CHD8_RAT [Swiss-Prot]
Description(s) found:
Found 11 descriptions.
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  • Chromodomain-helicase-DNA-binding protein 8 OS=Rattus norvegicus GN=Chd8 PE=1 SV=2 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 2581 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IDA]
    protein complex [UNKNOWN][IDA]
    chromatin [IEA]
    MLL1 complex [UNKNOWN][ISS]
    Biological Process: chromatin modification [IEA]
    in utero embryonic development [UNKNOWN][IEA]
    ATP-dependent chromatin remodeling [UNKNOWN][ISS]
    negative regulation of apoptosis [ISS]
    chromatin assembly or disassembly [IEA]
    Wnt receptor signaling pathway through beta-catenin [UNKNOWN][IDA]
    negative regulation of Wnt receptor signaling pathway [UNKNOWN][IDA]
    regulation of transcription [IEA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][ISS]
    positive regulation of transcription from RNA polymerase III promoter [UNKNOWN][ISS]
    Molecular Function: DNA-dependent ATPase activity [UNKNOWN][ISS]
    methylated histone residue binding [UNKNOWN][ISS]
    chromatin binding [IEA]
    beta-catenin binding [UNKNOWN][IDA][IPI]
    nucleotide binding [IEA]
    DNA binding [UNKNOWN][ISS]
    ATP binding [UNKNOWN][ISS]
    p53 binding [ISS]
    DNA helicase activity [UNKNOWN][ISS]
    protein binding [UNKNOWN][IPI]
    histone binding [ISS]
    transcription activator activity [UNKNOWN][ISS]
    transcription repressor activity [UNKNOWN][IDA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADPIMDLFD DPNLFGLDSL TDDSFNQVTQ DPIEEALGLP SSLDSLDQMN QDGGSGDVGN  60
   61 SSASDLVPPP EETASTELPK ESTAPAPESL TLHDYTTQPT SQEQPAQPVL QTSTPTSGLL 120
  121 QVSKSQEILS QGNPFMGVSA TAVSPSNTGG QPSQSAPKIV ILKAPPNSSV TGAHVAQIQA 180
  181 QGITSTAQPL VAGTANGGKV TFTKVLTGTP LRPGVSIVSG NTVLATKVPG NQAAVQRIVQ 240
  241 PSRPVKQLVL QPVKGSAPAG NPGATGPPLK PAVTLTSTPA QGESKRITLV LQQPQSGGPQ 300
  301 GHRHVVLGSL PGKIVLQGNQ LAALTQAKSA QGQPAKVVTI QLQVQQPQQK IQIVPQPPSS 360
  361 QPQPQPPPSA QPLTLSSVQQ AQIMGPGQNP GQRLSVPLKM VLQPQAGSSQ GASSGLSVVK 420
  421 VLSASEVAAL SSPASCAPHT AGKTGMEENR RLEHQKKQEK ANRIVAEAIA RARARGEQNI 480
  481 PRVLNEDELP SVRPEEEGEK KRRKKSSGER LKEEKPKKSK TAAASKTKGK SKLNTITPVV 540
  541 GKKRKRNTSS DNSDVEVMPA QSPREDEESS IQKRRSNRQV KRKKYTEDLD IKITDDEEEE 600
  601 EVDVTGPIKP EPILPEPVPE PDGETLPSMQ FFVENPSEED AAIVDKVLSM RVVKKELPSG 660
  661 QYTEAEEFFV KYKNYSYLHC EWATISQLEK DKRIHQKLKR FKTKMAQMRH FFHEDEEPFN 720
  721 PDYVEVDRIL DESHSVDKDN GEPVIYYLVK WCSLPYEDST WELKEDVDEG KIREFKRIQS 780
  781 RHPELKRVNR PQANAWKKLE LSHEYKNRNQ LREYQLEGVN WLLFNWYNRQ NCILADEMGL 840
  841 GKTIQSIAFL QEVYNVGIHG PFLVIAPLST ITNWEREFNT WTEMNTIVYH GSLASRQMIQ 900
  901 QYEMYCKDSR GRLIPGAYKF DALITTFEMI LSDCPELREI EWRCVIIDEA HRLKNRNCKL 960
  961 LDSLKHMDLE HKVLLTGTPL QNTVEELFSL LHFLEPSQFP SESEFLKDFG DLKTEEQVQK1020
 1021 LQAILKPMML RRLKEDVEKN LAPKQETIIE VELTNIQKKY YRAILEKNFS FLSKGAGHTN1080
 1081 MPNLLNTMME LRKCCNHPYL INGAEEKILM EFREACHIIP QDFHLQAMVR SAGKLVLIDK1140
 1141 LLPKLKAGGH KVLIFSQMVR CLDILEDYLI QRRYLYERID GRVRGNLRQA AIDRFSKPDS1200
 1201 DRFVFLLCTR AGGLGINLTA ADTCIIFDSD WNPQNDLQAQ ARCHRIGQSK AVKVYRLITR1260
 1261 NSYEREMFDK ASLKLGLDKA VLQSMSGRDG NITGIQQFSK KEIEDLLRKG AYAAIMEEDD1320
 1321 EGSKFCEEDI DQILLRRTTT ITIESEGKGS TFAKASFVAS ENRTDISLDD PNFWQKWAKK1380
 1381 ADLDMDLLNS KNNLVIDTPR VRKQTRHFST LKDDDLVEFS DLESEDDERP RSRRHDRHHT1440
 1441 YGRTDCFRVE KHLLVYGWGR WRDILSHGRF KRRMTERDVE TICRAILVYC LLHYRGDENI1500
 1501 KSFIWDLISP AENGKTKELQ NHSGLSIPVP RGRKGKKVKS QSTFDIHKAD WIRKYNPDTL1560
 1561 FQDESYKKHL KHQCNKVLLR VRMLYYLRQE VIGDQAEKVL GGAIASEIDI WFPVVDQLEV1620
 1621 PTTWWDSEAD KSLLIGVFKH GYEKYNTMRA DPALCFLEKA GRPDDKAIAA EHRVLDNFSD1680
 1681 LVEGIDFDKD CEDPEYKPLQ GPPKDPDDEG DPLMMMDEEI SVIDGDEAPV TQQPGHLFWP1740
 1741 PGSALTARLR RLVTAYQRSY KREQMKIEAA ERGDRRRRRC EAAFKLKEIA RREKQQRWTR1800
 1801 REQTDFYRVV STFGVEYDPD NMQFHWDRFR TFARLDKKTD ESLTKYFHGF VAMCRQVCRL1860
 1861 PPAAGDEPPD PNLFIEPITE ERASRTLYRI ELLRRLREQV LCHPLLEDRL ALCQPPGLEL1920
 1921 PKWWEPVRHD GELLRGAARH GVSQTDCNIM QDPDFSFLAA RMNYMQNHQA GASAASLSRC1980
 1981 STPLLHQQCT SRTASPSPLR PDVPAEKSPE ENAVQVPSLD SLTLKLEDEV VARSRLTPQD2040
 2041 YEIRVASSDT APLSRSVPPV KLEDDDDSDS ELDLSKLSPS SSSSSSSSSS SSSSDESEDE2100
 2101 KEEKLTADRS RPKLYDEESL LSLTMSQDGF PNEDGEQMTP ELLLLQERQR ASEWPKDRVL2160
 2161 INRIDLVCQA VLSGKWPSNR RSQEMTTGGI LGPGNHLLDS PSLTPGEYGD SPVPTPRSSS2220
 2221 AASMVEEEAS AVTTAAAQFT KLRRGMDEKE FTVQIKDEEG LKLTFQKHRL MANGVMGDGH2280
 2281 PLFHKKKGNR KKLVELEVEC MEEPNHLDVD LETRIPVINK VDGTLLVGDE APRRAELDMW2340
 2341 LQGHPEFAVD PRFLAYMEER RKQKWQRCKK NNKTELNCLG MEPVQPANSR NGKKGHYAET2400
 2401 AFNRVLPGPI APENSKKRVR RTRPDLSKMM ALMQGGSTGS LSLHNTFQHS SSNLQSVSSL2460
 2461 GHSSATSASL PFMPFVMGGA AAPPHVDSST MLHHHHHHPH PHHHHHHHPG LRTTGYPSSP2520
 2521 ATTTSGTALR LPTLQHEDDD EEEDEDDDDL SQGYDSSERD FSLIDDPMMP ANSDSSDDAD2580
 2581 D

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle