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Protein Overview: WBSCR22

General Information:
Name(s) found: WBSCR22 [HGNC (HUGO)]
Description(s) found:
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  • gi|40225427|gb|AAH11696.2| Williams Beuren syndrome chromosome region 22 [Homo sapiens] [NCBI NR]
  • gi|23831505|sp|O43709.2|WBS22_HUMAN RecName: Full=Uncharacterized methyltransferase WBSCR22; AltName: Full=Williams-Beuren syndrome chromosomal region 22 protein [NCBI NR]
  • gi|23199995|ref|NP_059998.2| Williams Beuren syndrome chromosome region 22 protein [Homo sapiens] [NCBI NR]
  • gi|21552766|gb|AAM62316.1|AF412034_1 Williams-Beuren syndrome critical region protein 22 [Homo sapiens] [NCBI NR]
  • gi|189054667|dbj|BAG37517.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|16226067|gb|AAL16066.1|AF420248_1 putative methyltransferase WBMT [Homo sapiens] [NCBI NR]
  • gi|158255668|dbj|BAF83805.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|127796288|gb|AAH01780.2| Williams Beuren syndrome chromosome region 22 [Homo sapiens] [NCBI NR]
  • gi|127795785|gb|AAH00169.2| Williams Beuren syndrome chromosome region 22 [Homo sapiens] [NCBI NR]
  • gi|119590063|gb|EAW69657.1| Williams Beuren syndrome chromosome region 22, isoform CRA_b [Homo sapiens] [NCBI NR]
  • Williams Beuren syndrome chromosome region 22 [HGNC (HUGO)]
  • (O43709) Putative methyltransferase HUSSY-03 (EC 2.1.1.-) (Williams-Beuren syndrome chromosome region 22 protein) (PP3381) [Swiss-Prot]
  • Probable 18S rRNA (guanine-N(7))-methyltransferase OS=Homo sapiens GN=WBSCR22 PE=1 SV=2 [Swiss-Prot]
  • Putative methyltransferase HUSSY-3 [hmr_yeast5_DM3-1_pombe.fasta]
  • Williams Beuren syndrome chromosome region 22 protein; Williams-Beuren candidate region putative methyltransferase [HMR_022704.fasta]
  • Williams Beuren syndrome chromosome region 22 protein [Homo sapiens]gi|40225427|gb|AAH11696.2| Williams Beuren syndrome chromosome region 22 protein [Homo sapiens]gi|21552766|gb|AAM62316.1| Williams-Beuren syndrome critical region protein 22 [Homo sapie [nrdb_11152004_Chlamydomonas]
  • Putative methyltransferase HUSSY-03 (Williams-Beuren syndrome chromosome region 22 protein) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Putative methyltransferase WBSCR22 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • Williams Beuren syndrome chromosome region 22 protein [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Putative methyltransferase HUSSY-03 [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • Williams Beuren syndrome chromosome region 22 protein; Williams-Beuren candidate region putative methyltransferase [Homo sapiens] [HumanGallus06162005.fasta]
  • Uncharacterized methyltransferase WBSCR22 (Williams-Beuren syndrome chromosomal region 22 protein) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Williams Beuren syndrome chromosome region 22 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Williams Beuren syndrome chromosome region 22, isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Williams-Beuren syndrome critical region protein 22 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • putative methyltransferase WBMT [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Putative methyltransferase WBSCR22 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF PUTATIVE METHYLTRANSFERASE HUSSY-03 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=WBSCR22 Isoform 1 of Uncharacterized methyltransferase WBSCR22 [human-ipi-250309-contam.fasta]
  • Putative methyltransferase WBSCR22 (Williams-Beuren syndrome chromosome region 22 protein) [nr-271106-contam.fasta]
  • IPI:IPI00013810.2|SWISS-PROT:O43709-1|TREMBL:A8K501;Q75ME3|ENSEMBL:ENSP00000265758|REFSEQ:NP_059998|H-INV:HIT000079379|VEGA:OTTHUMP00000160499 Tax_Id=9606 Gene_Symbol=WBSCR22 Isoform 1 of Uncharacterized methyltransferase WBSCR22 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=WBSCR22 Isoform 1 of Uncharacterized methyltransferase WBSCR22 ENSG00000071462 IPI00013810 IPI00456055 IPI00794639 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=WBSCR22 Isoform 1 of Putative methyltransferase WBSCR22 [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • Uncharacterized methyltransferase WBSCR22 OS=Homo sapiens GN=WBSCR22 PE=1 SV=2 [UniProtHuman070710.fasta]
  • O43709;Q96P12;Q9BQ58;Q9HBP9; RecName: Full=Uncharacterized methyltransferase WBSCR22; AltName: Full=Williams-Beuren syndrome chromosomal region 22 protein; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Uncharacterized methyltransferase WBSCR22 OS=Homo sapiens GN=WBSCR22 [011711_HMR.fasta]
  • GeneSymbol=WBSCR22 Synonyms=FLJ44236|HASJ4442|HUSSY-3|MGC19709|MGC2022|MGC5140|PP3381|WBMT Williams Beuren syndrome chromosome region 22 protein [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Uncharacterized methyltransferase WBSCR22 GN=WBSCR22 [Doctor+uniprot-HUMAN-120911.fasta]
  • Ribosome biogenesis methyltransferase WBSCR22 OS=Homo sapiens GN=WBSCR22 PE=1 SV=2 [140611-HUMAN-GFP.fasta]
  • Williams-Beuren syndrome chromosomal region 22 protein OS=Homo sapiens GN=WBSCR22 PE=1 SV=2 [uniport.HUMAN.20140709.contam.amyloid.fasta]
  • Probable 18S rRNA (guanine-N(7))-methyltransferase OS=Homo sapiens GN=BUD23 PE=1 SV=2 [human-uniprot-05July2017-contam-hTTBK1.fasta]
    • Organism: Homo sapiens
    Length: 281 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASRGRRPEH GGPPELFYDE TEARKYVRNS RMIDIQTRMA GRALELLYLP ENKPCYLLDI  60
   61 GCGTGLSGSY LSDEGHYWVG LDISPAMLDE AVDREIEGDL LLGDMGQGIP FKPGTFDGCI 120
  121 SISAVQWLCN ANKKSENPAK RLYCFFASLF SVLVRGSRAV LQLYPENSEQ LELITTQATK 180
  181 AGFSGGMVVD YPNSAKAKKF YLCLFSGPST FIPEGLSENQ DEVEPRESVF TNERFPLRMS 240
  241 RRGMVRKSRA WVLEKKERHR RQGREVRPDT QYTGRKRKPR F

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..281] PSI-BLAST 22.522879 Crystal structure of Ubiquinone/menaquinone biosynthesis methyltransferase-related protein (tm1389) from THERMOTOGA MARITIMA at 2.35 A resolution

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • rRNA methyltransferase activity
    		•  4.09362182773099 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.00768472859991 bayes_pls_golite062009
  • methyltransferase activity
    		•  3.57681394097837 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  3.49392219433935 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.39429041855776 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  3.07428840534971 bayes_pls_golite062009
  • transferase activity
    		•  2.926540904444 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  1.83964463328968 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  1.76571145896453 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  1.75675289134467 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • rRNA (guanine) methyltransferase activity
    		•  1.10713374933008 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  0.94499223839747 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.914549843668268 bayes_pls_golite062009
  • DNA binding
    		•  0.86027591375666 bayes_pls_golite062009
  • binding
    		•  0.777596419415505 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.616949327277483 bayes_pls_golite062009
  • RNA binding
    		•  0.417524996559564 bayes_pls_golite062009
  • O-methyltransferase activity
    		•  0.250946859465502 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.0408000230099101 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle