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Protein Overview: FASLG

General Information:
Name(s) found: FASLG [HGNC (HUGO)]
Description(s) found:
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  • gi|887456|emb|CAA61474.1| Fasligand [Homo sapiens] [NCBI NR]
  • pir||I38707 Fas ligand - human [NCBI NR]
  • gi|624628|gb|AAC50071.1| Fas ligand [NCBI NR]
  • gi|595431|gb|AAC50124.1| Fas ligand [NCBI NR]
  • gi|4557329|ref|NP_000630.1| fas ligand [Homo sapiens] [NCBI NR]
  • gi|28569614|gb|AAO43991.1| Fas ligand [Homo sapiens] [NCBI NR]
  • gi|2168140|emb|CAB09424.1| Fas ligand (TNF superfamily, member 6) [Homo sapiens] [NCBI NR]
  • gi|189054595|dbj|BAG37389.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|17028381|gb|AAH17502.1| Fas ligand (TNF superfamily, member 6) [Homo sapiens] [NCBI NR]
  • gi|1369902|dbj|BAA07320.1| Fas ligand [Homo sapiens] [NCBI NR]
  • gi|1345957|sp|P48023.1|TNFL6_HUMAN RecName: Full=Tumor necrosis factor ligand superfamily member 6; AltName: Full=Fas antigen ligand; Short=Fas ligand; AltName: Full=CD95L protein; AltName: Full=Apoptosis antigen ligand; Short=APTL; AltName: CD_antigen=CD [NCBI NR]
  • gi|119611342|gb|EAW90936.1| Fas ligand (TNF superfamily, member 6), isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|117606530|gb|ABK41922.1| Fas ligand (TNF superfamily, member 6) [Homo sapiens] [NCBI NR]
  • Fas ligand (TNF superfamily, member 6) [HGNC (HUGO)]
  • Tumor necrosis factor ligand superfamily member 6 OS=Homo sapiens GN=FASLG PE=1 SV=1 [Swiss-Prot]
  • (P48023) Tumor necrosis factor ligand superfamily member 6 (FAS antigen ligand) (Apoptosis antigen ligand) (APTL) (CD178 antigen) [Swiss-Prot]
  • Splice isoform 1 of P48023 [hmr_yeast5_DM3-1_pombe.fasta]
  • apoptosis (APO-1) antigen ligand 1; CD95 ligand [HMR_022704.fasta]
  • apoptosis (APO-1) antigen ligand 1 [Homo sapiens]gi|17028381|gb|AAH17502.1| Apoptosis (APO-1) antigen ligand 1 [Homo sapiens]gi|28569614|gb|AAO43991.1| Fas ligand [Homo sapiens]gi|2168140|emb|CAB09424.1| dJ105D12.2 (tumor necrosis factor (ligand) super [nrdb_11152004_Chlamydomonas]
  • Tumor necrosis factor ligand superfamily member 6 (FAS antigen ligand) (Apoptosis antigen ligand) (APTL) (CD178 antigen) [Contains: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, solubl [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Tumor necrosis factor ligand superfamily member 6 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_000639) apoptosis (APO-1) antigen ligand 1 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • fas ligand [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • apoptosis (APO-1) antigen ligand 1; CD95 ligand [Homo sapiens] [HumanGallus06162005.fasta]
  • Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand) (Fas ligand) (CD178 antigen) (CD95L protein) (Apoptosis antigen ligand) (APTL) [Contains: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Fas ligand (TNF superfamily, member 6) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Fas ligand [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Fas ligand (TNF superfamily, member 6), isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Fasligand [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Fas ligand [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Tumor necrosis factor ligand superfamily member 6 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=FASLG Isoform 1 of Tumor necrosis factor ligand superfamily member 6 [human-ipi-250309-contam.fasta]
  • tumor necrosis factor (ligand) superfamily, member 6 [Homo sapiens] [nr-271106-contam.fasta]
  • IPI:IPI00007577.1|SWISS-PROT:P48023-1|TREMBL:Q0VHD7;Q53ZZ1|ENSEMBL:ENSP00000356694|REFSEQ:NP_000630|H-INV:HIT000101419|VEGA:OTTHUMP00000032708 Tax_Id=9606 Gene_Symbol=FASLG Isoform 1 of Tumor necrosis factor ligand superfamily member 6 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=FASLG Isoform 1 of Tumor necrosis factor ligand superfamily member 6 ENSG00000117560 IPI00220870 IPI00007577 [drosphohumanreversed.fasta]
  • tumor necrosis factor ligand superfamily member 6 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P48023;Q9BZP9; RecName: Full=Tumor necrosis factor ligand superfamily member 6; AltName: Full=Fas antigen ligand; AltName: Full=CD95 ligand; AltName: Full=Apoptosis antigen ligand; AltName: CD_antigen=CD178; Contains: RecName: Full=Tumor necrosis factor ligand superfamily member 6, membrane form; Contains: RecName: Full=Tumor necrosis factor ligand superfamily member 6, soluble form; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Tumor necrosis factor ligand superfamily member 6 OS=Homo sapiens GN=FASLG [011711_HMR.fasta]
  • GeneSymbol=FASLG Synonyms=APT1LG1|CD178|CD95-L|CD95L|FASL|TNFSF6 tumor necrosis factor ligand superfamily member 6 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Tumor necrosis factor ligand superfamily member 6 GN=FASLG [Doctor+uniprot-HUMAN-120911.fasta]
  • FAS ligand OS=Homo sapiens GN=TNFSF6 PE=2 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 281 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP PPPLPPPPPP  60
   61 PPLPPLPLPP LKKRGNHSTG LCLLVMFFMV LVALVGLGLG MFQLFHLQKE LAELRESTSQ 120
  121 MHTASSLEKQ IGHPSPPPEK KELRKVAHLT GKSNSRSMPL EWEDTYGIVL LSGVKYKKGG 180
  181 LVINETGLYF VYSKVYFRGQ SCNNLPLSHK VYMRNSKYPQ DLVMMEGKMM SYCTTGQMWA 240
  241 RSSYLGAVFN LTSADHLYVN VSELSLVNFE ESQTFFGLYK L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..85] MSA 1.029997 View MSA. No confident structure predictions are available.
    2 View Details [86..281] PSI-BLAST 39.39794 Apoptosis-2 ligand, apo2l/TRAIL

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • receptor binding
    		•  3.37824597039547 bayes_pls_golite062009
  • tumor necrosis factor receptor superfamily binding
    		•  2.2657673851253 bayes_pls_golite062009
  • protein binding
    		•  2.25413201891408 bayes_pls_golite062009
  • binding
    		•  1.55055236820725 bayes_pls_golite062009
  • tumor necrosis factor receptor binding
    		•  1.07319043778379 bayes_pls_golite062009
  • cytokine activity
    		•  0.82341093302063 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle