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View Structure Prediction Details

Protein: FASLG
Organism: Homo sapiens
Length: 281 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FASLG.

Description E-value Query
Range		 Subject
Range
gi|60830321 - gi|60830321|gb|AAX36923.1| tumor necrosis factor superfamily member 6 [synthetic construct]
 1.0E-94 [1..281] [1..281]
gi|61658441 - gi|61658441|gb|AAX49569.1| CD95 ligand [Homo sapiens]
 6.0E-94 [1..281] [1..281]
gi|114565468 - gi|114565468|ref|XP_524967.2| PREDICTED: fas ligand [Pan troglodytes]
 1.0E-93 [1..281] [1..280]
gi|74136237, gi|... - gi|74136237|ref|NP_001028010.1| FAS antigen CD95 [Macaca mulatta], gi|13650010|gb|AAK37539.1|AF34485...
 2.0E-93 [1..281] [1..280]
TNFL6_MACFA - Tumor necrosis factor ligand superfamily member 6 OS=Macaca fascicularis GN=FASLG PE=2 SV=1
TNFL6_MACMU - Tumor necrosis factor ligand superfamily member 6 OS=Macaca mulatta GN=FASLG PE=2 SV=1
TNFL6_MACNE - Tumor necrosis factor ligand superfamily member 6 OS=Macaca nemestrina GN=FASLG PE=2 SV=1
 2.0E-93 [1..281] [1..280]
TNFL6_CERAT - Tumor necrosis factor ligand superfamily member 6 OS=Cercocebus atys GN=FASLG PE=2 SV=1
 4.0E-93 [1..281] [1..280]
TNFL6_FELCA - Tumor necrosis factor ligand superfamily member 6 OS=Felis catus GN=FASLG PE=2 SV=1
 4.0E-90 [1..281] [1..280]
gi|913760 - gi|913760|gb|AAB33780.1| Fas ligand; FasL [Mus sp.]
TNFL6_MOUSE - Tumor necrosis factor ligand superfamily member 6 OS=Mus musculus GN=Faslg PE=1 SV=1
 1.0E-89 [1..281] [1..279]

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Predicted Domain #1
Region A:
Residues: [1-85] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP PPPLPPPPPP  60
   61 PPLPPLPLPP LKKRGNHSTG LCLLV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [86-281] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFFMVLVALV GLGLGMFQLF HLQKELAELR ESTSQMHTAS SLEKQIGHPS PPPEKKELRK  60
   61 VAHLTGKSNS RSMPLEWEDT YGIVLLSGVK YKKGGLVINE TGLYFVYSKV YFRGQSCNNL 120
  121 PLSHKVYMRN SKYPQDLVMM EGKMMSYCTT GQMWARSSYL GAVFNLTSAD HLYVNVSELS 180
  181 LVNFEESQTF FGLYKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.39794
Match: 1dg6A
Description: Apoptosis-2 ligand, apo2l/TRAIL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 3.37824597039547 bayes_pls_golite062009
tumor necrosis factor receptor superfamily binding 2.2657673851253 bayes_pls_golite062009
protein binding 2.25413201891408 bayes_pls_golite062009
binding 1.55055236820725 bayes_pls_golite062009
tumor necrosis factor receptor binding 1.07319043778379 bayes_pls_golite062009
cytokine activity 0.82341093302063 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle