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Protein Overview: SLC12A2

General Information:
Name(s) found: SLC12A2 [HGNC (HUGO)]
Description(s) found:
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  • gi|903682|gb|AAC50561.1| bumetanide-sensitive Na-K-Cl cotransporter [Homo sapiens] [NCBI NR]
  • gi|4506975|ref|NP_001037.1| solute carrier family 12 (sodium/potassium/chloride transporters), member 2 [Homo sapiens] [NCBI NR]
  • gi|30721813|gb|AAP33906.1| bumetanide-sensitive Na-K-Cl cotransporter [Homo sapiens] [NCBI NR]
  • pir||A57187 bumetanide-sensitive Na-K-Cl cotransporter - human [NCBI NR]
  • gi|1709292|sp|P55011.1|S12A2_HUMAN RecName: Full=Solute carrier family 12 member 2; AltName: Full=Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; AltName: Full=Basolateral Na-K-Cl symporter [NCBI NR]
  • gi|119582798|gb|EAW62394.1| solute carrier family 12 (sodium/potassium/chloride transporters), member 2, isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|119582797|gb|EAW62393.1| solute carrier family 12 (sodium/potassium/chloride transporters), member 2, isoform CRA_b [Homo sapiens] [NCBI NR]
  • solute carrier family 12 (sodium/potassium/chloride transporters), member 2 [HGNC (HUGO)]
  • Solute carrier family 12 member 2 OS=Homo sapiens GN=SLC12A2 PE=1 SV=1 [Swiss-Prot]
  • (P55011) Solute carrier family 12 member 2 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) (Basolateral Na-K-Cl symporter) [Swiss-Prot]
  • Splice isoform 1 of P55011 [hmr_yeast5_DM3-1_pombe.fasta]
  • solute carrier family 12 (sodium/potassium/chloride transporters), member 2; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; basolateral Na-K-Cl symporter [HMR_022704.fasta]
  • solute carrier family 12 (sodium/potassium/chloride transporters), member 2 [Homo sapiens]gi|30721813|gb|AAP33906.1| bumetanide-sensitive Na-K-Cl cotransporter [Homo sapiens]gi|903682|gb|AAC50561.1| bumetanide-sensitive Na-K-Cl cotransportergi|2134840| [nrdb_11152004_Chlamydomonas]
  • Solute carrier family 12 member 2 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) (Basolateral Na-K-Cl symporter) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Solute carrier family 12 member 2 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_001046) solute carrier family 12 (sodium/potassium/chloride transporters), member 2; Solute carrier family 12 (sodium/potassium/chloride transporters), [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • solute carrier family 12 (sodium/potassium/chloride transporters), member 2 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Solute carrier family 12, member 2 [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • solute carrier family 12 (sodium/potassium/chloride transporters), member 2; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; basolateral Na-K-Cl symporter [Homo sapiens] [HumanGallus06162005.fasta]
  • solute carrier family 12 (sodium/potassium/chloride transporters), member 2, isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • bumetanide-sensitive Na-K-Cl cotransporter [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Solute carrier family 12 member 2 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF SOLUTE CARRIER FAMILY 12 MEMBER 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=SLC12A2 Isoform 1 of Solute carrier family 12 member 2 [human-ipi-250309-contam.fasta]
  • IPI:IPI00022649.3|SWISS-PROT:P55011-1|TREMBL:Q53ZR1|ENSEMBL:ENSP00000262461|REFSEQ:NP_001037|H-INV:HIT000085710|VEGA:OTTHUMP00000159234 Tax_Id=9606 Gene_Symbol=SLC12A2 Isoform 1 of Solute carrier family 12 member 2 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=SLC12A2 Isoform 1 of Solute carrier family 12 member 2 ENSG00000064651 IPI00022649 IPI00220844 IPI00479477 [drosphohumanreversed.fasta]
  • solute carrier family 12 member 2 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P55011;Q8N713;Q8WWH7; RecName: Full=Solute carrier family 12 member 2; AltName: Full=Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; AltName: Full=Basolateral Na-K-Cl symporter; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Solute carrier family 12 member 2 OS=Homo sapiens GN=SLC12A2 [011711_HMR.fasta]
  • GeneSymbol=SLC12A2 Synonyms=BSC|BSC2|MGC104233|NKCC1 solute carrier family 12 member 2 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Solute carrier family 12 member 2 GN=SLC12A2 [Doctor+uniprot-HUMAN-120911.fasta]
  • Bumetanide-sensitive Na-K-Cl cotransporter OS=Homo sapiens GN=SLC12A2 PE=2 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 1212 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPRPTAPSS GAPGLAGVGE TPSAAALAAA RVELPGTAVP SVPEDAAPAS RDGGGVRDEG  60
   61 PAAAGDGLGR PLGPTPSQSR FQVDLVSENA GRAAAAAAAA AAAAAAAGAG AGAKQTPADG 120
  121 EASGESEPAK GSEEAKGRFR VNFVDPAASS SAEDSLSDAA GVGVDGPNVS FQNGGDTVLS 180
  181 EGSSLHSGGG GGSGHHQHYY YDTHTNTYYL RTFGHNTMDA VPRIDHYRHT AAQLGEKLLR 240
  241 PSLAELHDEL EKEPFEDGFA NGEESTPTRD AVVTYTAESK GVVKFGWIKG VLVRCMLNIW 300
  301 GVMLFIRLSW IVGQAGIGLS VLVIMMATVV TTITGLSTSA IATNGFVRGG GAYYLISRSL 360
  361 GPEFGGAIGL IFAFANAVAV AMYVVGFAET VVELLKEHSI LMIDEINDIR IIGAITVVIL 420
  421 LGISVAGMEW EAKAQIVLLV ILLLAIGDFV IGTFIPLESK KPKGFFGYKS EIFNENFGPD 480
  481 FREEETFFSV FAIFFPAATG ILAGANISGD LADPQSAIPK GTLLAILITT LVYVGIAVSV 540
  541 GSCVVRDATG NVNDTIVTEL TNCTSAACKL NFDFSSCESS PCSYGLMNNF QVMSMVSGFT 600
  601 PLISAGIFSA TLSSALASLV SAPKIFQALC KDNIYPAFQM FAKGYGKNNE PLRGYILTFL 660
  661 IALGFILIAE LNVIAPIISN FFLASYALIN FSVFHASLAK SPGWRPAFKY YNMWISLLGA 720
  721 ILCCIVMFVI NWWAALLTYV IVLGLYIYVT YKKPDVNWGS STQALTYLNA LQHSIRLSGV 780
  781 EDHVKNFRPQ CLVMTGAPNS RPALLHLVHD FTKNVGLMIC GHVHMGPRRQ AMKEMSIDQA 840
  841 KYQRWLIKNK MKAFYAPVHA DDLREGAQYL MQAAGLGRMK PNTLVLGFKK DWLQADMRDV 900
  901 DMYINLFHDA FDIQYGVVVI RLKEGLDISH LQGQEELLSS QEKSPGTKDV VVSVEYSKKS 960
  961 DLDTSKPLSE KPITHKVEEE DGKTATQPLL KKESKGPIVP LNVADQKLLE ASTQFQKKQG1020
 1021 KNTIDVWWLF DDGGLTLLIP YLLTTKKKWK DCKIRVFIGG KINRIDHDRR AMATLLSKFR1080
 1081 IDFSDIMVLG DINTKPKKEN IIAFEEIIEP YRLHEDDKEQ DIADKMKEDE PWRITDNELE1140
 1141 LYKTKTYRQI RLNELLKEHS STANIIVMSL PVARKGAVSS ALYMAWLEAL SKDLPPILLV1200
 1201 RGNHQSVLTF YS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] PSI-BLAST 5.0 No description for 1y0fA was found.
    2 View Details [216..262] Pfam 40.119186 No description for PF08403.1 was found. No confident structure predictions are available.
    3 View Details [263..777] PSI-BLAST 8.0 Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters
    4 View Details [778..976] MSA 1.261959 View MSA. No confident structure predictions are available.
    5 View Details [977..1032] deduced N/A No confident structure predictions are available.
    6 View Details [1033..1212] MSA 2.117951 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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