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View Structure Prediction Details

Protein: SLC12A2
Organism: Homo sapiens
Length: 1212 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SLC12A2.

Description E-value Query
Range
Subject
Range
gi|114601480 - gi|114601480|ref|XP_526998.2| PREDICTED: solute carrier family 12 (sodium/potassium/chloride transpo...
0.0 [1..1212] [1..1211]
gi|3342264, gi|1... - gi|3342264|gb|AAC27557.1| Na-K-Cl cotransporter [Rattus norvegicus], gi|13929130|ref|NP_113986.1| so...
0.0 [1..1212] [1..1203]
gi|109078451 - gi|109078451|ref|XP_001098624.1| PREDICTED: solute carrier family 12 (sodium/potassium/chloride tran...
0.0 [1..1212] [1..1210]
gi|27807511, gi|... - gi|27807511|ref|NP_777207.1| solute carrier family 12 (sodium/potassium/chloride transporters), memb...
0.0 [1..1212] [1..1201]
S122_MOUSE, S12A... - Solute carrier family 12 member 2 OS=Mus musculus GN=Slc12a2 PE=1 SV=1, (P55012) Solute carrier fami...
0.0 [1..1212] [1..1205]
gi|73971056 - gi|73971056|ref|XP_538611.2| PREDICTED: similar to Solute carrier family 12, member 2 (Bumetanide-se...
0.0 [8..1212] [49..1263]
gi|82582275 - gi|82582275|gb|ABB84251.1| Na-K-2Cl cotransporter [Dicentrarchus labrax]
0.0 [64..1212] [23..1161]
gi|21542567 - gi|21542567|gb|AAH33003.1| SLC12A2 protein [Homo sapiens]
0.0 [1..1149] [1..1149]

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Predicted Domain #1
Region A:
Residues: [1-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPRPTAPSS GAPGLAGVGE TPSAAALAAA RVELPGTAVP SVPEDAAPAS RDGGGVRDEG  60
   61 PAAAGDGLGR PLGPTPSQSR FQVDLVSENA GRAAAAAAAA AAAAAAAGAG AGAKQTPADG 120
  121 EASGESEPAK GSEEAKGRFR VNFVDPAASS SAEDSLSDAA GVGVDGPNVS FQNGGDTVLS 180
  181 EGSSLHSGGG GGSGHHQHYY YDTHTNTYYL RTFGH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1y0fA
Description: No description for 1y0fA was found.

Predicted Domain #2
Region A:
Residues: [216-262]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTMDAVPRID HYRHTAAQLG EKLLRPSLAE LHDELEKEPF EDGFANG

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 40.119186
Match: PF08403.1
Description: No description for PF08403.1 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [263-777]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EESTPTRDAV VTYTAESKGV VKFGWIKGVL VRCMLNIWGV MLFIRLSWIV GQAGIGLSVL  60
   61 VIMMATVVTT ITGLSTSAIA TNGFVRGGGA YYLISRSLGP EFGGAIGLIF AFANAVAVAM 120
  121 YVVGFAETVV ELLKEHSILM IDEINDIRII GAITVVILLG ISVAGMEWEA KAQIVLLVIL 180
  181 LLAIGDFVIG TFIPLESKKP KGFFGYKSEI FNENFGPDFR EEETFFSVFA IFFPAATGIL 240
  241 AGANISGDLA DPQSAIPKGT LLAILITTLV YVGIAVSVGS CVVRDATGNV NDTIVTELTN 300
  301 CTSAACKLNF DFSSCESSPC SYGLMNNFQV MSMVSGFTPL ISAGIFSATL SSALASLVSA 360
  361 PKIFQALCKD NIYPAFQMFA KGYGKNNEPL RGYILTFLIA LGFILIAELN VIAPIISNFF 420
  421 LASYALINFS VFHASLAKSP GWRPAFKYYN MWISLLGAIL CCIVMFVINW WAALLTYVIV 480
  481 LGLYIYVTYK KPDVNWGSST QALTYLNALQ HSIRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.0
Match: 2a65A
Description: Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [778-976]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGVEDHVKNF RPQCLVMTGA PNSRPALLHL VHDFTKNVGL MICGHVHMGP RRQAMKEMSI  60
   61 DQAKYQRWLI KNKMKAFYAP VHADDLREGA QYLMQAAGLG RMKPNTLVLG FKKDWLQADM 120
  121 RDVDMYINLF HDAFDIQYGV VVIRLKEGLD ISHLQGQEEL LSSQEKSPGT KDVVVSVEYS 180
  181 KKSDLDTSKP LSEKPITHK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [977-1032]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VEEEDGKTAT QPLLKKESKG PIVPLNVADQ KLLEASTQFQ KKQGKNTIDV WWLFDD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1033-1212]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGLTLLIPYL LTTKKKWKDC KIRVFIGGKI NRIDHDRRAM ATLLSKFRID FSDIMVLGDI  60
   61 NTKPKKENII AFEEIIEPYR LHEDDKEQDI ADKMKEDEPW RITDNELELY KTKTYRQIRL 120
  121 NELLKEHSST ANIIVMSLPV ARKGAVSSAL YMAWLEALSK DLPPILLVRG NHQSVLTFYS 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle