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Protein Overview: MSH6

General Information:
Name(s) found: MSH6 [HGNC (HUGO)]
Description(s) found:
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  • gi|68067672|sp|P52701.2|MSH6_HUMAN RecName: Full=DNA mismatch repair protein Msh6; AltName: Full=MutS-alpha 160 kDa subunit; AltName: Full=G/T mismatch-binding protein; Short=GTMBP; Short=GTBP; AltName: Full=p160 [NCBI NR]
  • gi|6063479|gb|AAB39212.2| hMSH6 protein [Homo sapiens] [NCBI NR]
  • gi|4504191|ref|NP_000170.1| mutS homolog 6 [Homo sapiens] [NCBI NR]
  • gi|13279008|gb|AAH04246.1| MutS homolog 6 (E. coli) [Homo sapiens] [NCBI NR]
  • gi|1294813|gb|AAC50461.1| G/T mismatch binding protein [NCBI NR]
  • gi|119620614|gb|EAX00209.1| mutS homolog 6 (E. coli), isoform CRA_b [Homo sapiens] [NCBI NR]
  • mutS homolog 6 (E. coli) [HGNC (HUGO)]
  • DNA mismatch repair protein Msh6 OS=Homo sapiens GN=MSH6 PE=1 SV=2 [Swiss-Prot]
  • MutS [hmr_yeast5_DM3-1_pombe.fasta]
  • mutS homolog 6; G/T mismatch-binding protein; mutS (E. coli) homolog 6 [HMR_022704.fasta]
  • mutS homolog 6 [Homo sapiens]gi|13279008|gb|AAH04246.1| MutS homolog 6 [Homo sapiens]gi|6063479|gb|AAB39212.2| hMSH6 protein [Homo sapiens]gi|1294813|gb|AAC50461.1| G/T mismatch binding protein [nrdb_11152004_Chlamydomonas]
  • DNA mismatch repair protein MSH6 (MutS-alpha 160 kDa subunit) (G/T mismatch binding protein) (GTBP) (GTMBP) (p160) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform GTBP-N of DNA mismatch repair protein MSH6 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_000179) mutS homolog 6 (E. coli); G/T mismatch-binding protein; mutS (E. coli) homolog 6 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • mutS homolog 6 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • mutS homolog 6; G/T mismatch-binding protein; mutS (E. coli) homolog 6 [Homo sapiens] [HumanGallus06162005.fasta]
  • DNA mismatch repair protein Msh6 (MutS-alpha 160 kDa subunit) (G/T mismatch-binding protein) (GTMBP) (GTBP) (p160) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • mutS homolog 6 (E. coli), isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • MutS homolog 6 (E. coli) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • hMSH6 protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • G/T mismatch binding protein [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform GTBP-N of DNA mismatch repair protein MSH6 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • RecName: Full=DNA mismatch repair protein Msh6; AltName: Full=MutS-alpha 160 kDa subunit; AltName: Full=G/T mismatch-binding protein; Short=GTMBP; Short=GTBP; AltName: Full=p160 [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=MSH6 Isoform GTBP-N of DNA mismatch repair protein Msh6 [human-ipi-250309-contam.fasta]
  • DNA mismatch repair protein MSH6 (MutS-alpha 160 kDa subunit) (G/T mismatch-binding protein) (GTBP) (GTMBP) (p160) [nr-271106-contam.fasta]
  • IPI:IPI00384456.4|SWISS-PROT:P52701-1|TREMBL:B4DF41;B4E3I4;Q1L838|ENSEMBL:ENSP00000234420|REFSEQ:NP_000170|H-INV:HIT000218941|VEGA:OTTHUMP00000159397 Tax_Id=9606 Gene_Symbol=MSH6 Isoform GTBP-N of DNA mismatch repair protein Msh6 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=MSH6 Isoform GTBP-N of DNA mismatch repair protein MSH6 ENSG00000116062 IPI00384456 IPI00440122 IPI00106847 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=MSH6 Isoform GTBP-N of DNA mismatch repair protein MSH6 [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • DNA mismatch repair protein Msh6 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P52701;O43706;O43917;Q8TCX4;Q9BTB5; RecName: Full=DNA mismatch repair protein Msh6; AltName: Full=MutS-alpha 160 kDa subunit; AltName: Full=G/T mismatch-binding protein; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform GTBP-N of DNA mismatch repair protein Msh6 OS=Homo sapiens GN=MSH6 [011711_HMR.fasta]
  • IPI:IPI00384456.4|SWISS-PROT:P52701-1|TREMBL:B4DF41;B4E3I4;Q1L838;Q3SWU9|ENSEMBL:ENSP00000234420|REFSEQ:NP_000170|H-INV:HIT000218941|VEGA:OTTHUMP00000159397 Tax_Id=9606 Gene_Symbol=MSH6 Isoform GTBP-N of DNA mismatch repair protein Msh6 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=MSH6 Synonyms=GTBP|HNPCC5|HSAP DNA mismatch repair protein Msh6 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00384456.4|SWISS-PROT:P52701-1|TREMBL:Q1L838|ENSEMBL:ENSP00000234420|REFSEQ:NP_000170|H-INV:HIT000218941|VEGA:OTTHUMP00000159397 Tax_Id=9606 Gene_Symbol=MSH6 Isoform GTBP-N of DNA mismatch repair protein Msh6 [ipi.HUMAN.20110912.fasta]
  • DNA mismatch repair protein Msh6 GN=MSH6 [Doctor+uniprot-HUMAN-120911.fasta]
  • IPI:IPI00384456.4|SWISS-PROT:P52701-1|TREMBL:Q1L838;Q3SWU9|ENSEMBL:ENSP00000234420|REFSEQ:NP_000170|H-INV:HIT000218941|VEGA:OTTHUMP00000159397 Tax_Id=9606 Gene_Symbol=MSH6 Isoform GTBP-N of DNA mismatch repair protein Msh6 [ipi.HUMAN.fasta.20110927]
    • Organism: Homo sapiens
    Length: 1360 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRQSTLYSF FPKSPALSDA NKASARASRE GGRAAAAPGA SPSPGGDAAW SEAGPGPRPL  60
   61 ARSASPPKAK NLNGGLRRSV APAAPTSCDF SPGDLVWAKM EGYPWWPCLV YNHPFDGTFI 120
  121 REKGKSVRVH VQFFDDSPTR GWVSKRLLKP YTGSKSKEAQ KGGHFYSAKP EILRAMQRAD 180
  181 EALNKDKIKR LELAVCDEPS EPEEEEEMEV GTTYVTDKSE EDNEIESEEE VQPKTQGSRR 240
  241 SSRQIKKRRV ISDSESDIGG SDVEFKPDTK EEGSSDEISS GVGDSESEGL NSPVKVARKR 300
  301 KRMVTGNGSL KRKSSRKETP SATKQATSIS SETKNTLRAF SAPQNSESQA HVSGGGDDSS 360
  361 RPTVWYHETL EWLKEEKRRD EHRRRPDHPD FDASTLYVPE DFLNSCTPGM RKWWQIKSQN 420
  421 FDLVICYKVG KFYELYHMDA LIGVSELGLV FMKGNWAHSG FPEIAFGRYS DSLVQKGYKV 480
  481 ARVEQTETPE MMEARCRKMA HISKYDRVVR REICRIITKG TQTYSVLEGD PSENYSKYLL 540
  541 SLKEKEEDSS GHTRAYGVCF VDTSLGKFFI GQFSDDRHCS RFRTLVAHYP PVQVLFEKGN 600
  601 LSKETKTILK SSLSCSLQEG LIPGSQFWDA SKTLRTLLEE EYFREKLSDG IGVMLPQVLK 660
  661 GMTSESDSIG LTPGEKSELA LSALGGCVFY LKKCLIDQEL LSMANFEEYI PLDSDTVSTT 720
  721 RSGAIFTKAY QRMVLDAVTL NNLEIFLNGT NGSTEGTLLE RVDTCHTPFG KRLLKQWLCA 780
  781 PLCNHYAIND RLDAIEDLMV VPDKISEVVE LLKKLPDLER LLSKIHNVGS PLKSQNHPDS 840
  841 RAIMYEETTY SKKKIIDFLS ALEGFKVMCK IIGIMEEVAD GFKSKILKQV ISLQTKNPEG 900
  901 RFPDLTVELN RWDTAFDHEK ARKTGLITPK AGFDSDYDQA LADIRENEQS LLEYLEKQRN 960
  961 RIGCRTIVYW GIGRNRYQLE IPENFTTRNL PEEYELKSTK KGCKRYWTKT IEKKLANLIN1020
 1021 AEERRDVSLK DCMRRLFYNF DKNYKDWQSA VECIAVLDVL LCLANYSRGG DGPMCRPVIL1080
 1081 LPEDTPPFLE LKGSRHPCIT KTFFGDDFIP NDILIGCEEE EQENGKAYCV LVTGPNMGGK1140
 1141 STLMRQAGLL AVMAQMGCYV PAEVCRLTPI DRVFTRLGAS DRIMSGESTF FVELSETASI1200
 1201 LMHATAHSLV LVDELGRGTA TFDGTAIANA VVKELAETIK CRTLFSTHYH SLVEDYSQNV1260
 1261 AVRLGHMACM VENECEDPSQ ETITFLYKFI KGACPKSYGF NAARLANLPE EVIQKGHRKA1320
 1321 REFEKMNQSL RLFREVCLAS ERSTVDAEAV HKLLTLIKEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..204] PSI-BLAST 20.0 No description for 2gfuA was found.
    2 View Details [205..341] FFAS03 1.05 No description for 2j63A was found.
    3 View Details [342..1360] PSI-BLAST 1000.0 No description for 2o8bB was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.64

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle