YRC Public Data Repository - Protein Structure Prediction

Protein:	MSH6
Organism:	Homo sapiens
Length:	1360 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSH6.

Description	E-value	Query Range	Subject Range
MSH6 - mutS homolog 6 (E. coli)	0.0	[1..1360]	[1..1360]
gi\|109102886 - gi\|109102886\|ref\|XP_001113749.1\| PREDICTED: similar to mutS homolog 6 [Macaca mulatta]	0.0	[1..1360]	[1..1360]
gi\|76629176 - gi\|76629176\|ref\|XP_611908.2\| PREDICTED: similar to G/T mismatch binding protein isoform 1 [Bos tauru...	0.0	[1..1360]	[1..1360]
MSH6_MOUSE - DNA mismatch repair protein Msh6 OS=Mus musculus GN=Msh6 PE=1 SV=3	0.0	[1..1360]	[1..1358]
gi\|73970143 - gi\|73970143\|ref\|XP_531814.2\| PREDICTED: similar to mutS homolog 6 [Canis familiaris]	0.0	[86..1360]	[8..1283]

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Predicted Domain #1

Region A:
Residues: [1-204]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRQSTLYSF FPKSPALSDA NKASARASRE GGRAAAAPGA SPSPGGDAAW SEAGPGPRPL  60
   61 ARSASPPKAK NLNGGLRRSV APAAPTSCDF SPGDLVWAKM EGYPWWPCLV YNHPFDGTFI 120
  121 REKGKSVRVH VQFFDDSPTR GWVSKRLLKP YTGSKSKEAQ KGGHFYSAKP EILRAMQRAD 180
  181 EALNKDKIKR LELAVCDEPS EPEE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.0
Match:	2gfuA
Description:	No description for 2gfuA was found.

Predicted Domain #2

Region A:
Residues: [205-341]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEEMEVGTTY VTDKSEEDNE IESEEEVQPK TQGSRRSSRQ IKKRRVISDS ESDIGGSDVE  60
   61 FKPDTKEEGS SDEISSGVGD SESEGLNSPV KVARKRKRMV TGNGSLKRKS SRKETPSATK 120
  121 QATSISSETK NTLRAFS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.05
Match:	2j63A
Description:	No description for 2j63A was found.

Predicted Domain #3

Region A:
Residues: [342-1360]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APQNSESQAH VSGGGDDSSR PTVWYHETLE WLKEEKRRDE HRRRPDHPDF DASTLYVPED  60
   61 FLNSCTPGMR KWWQIKSQNF DLVICYKVGK FYELYHMDAL IGVSELGLVF MKGNWAHSGF 120
  121 PEIAFGRYSD SLVQKGYKVA RVEQTETPEM MEARCRKMAH ISKYDRVVRR EICRIITKGT 180
  181 QTYSVLEGDP SENYSKYLLS LKEKEEDSSG HTRAYGVCFV DTSLGKFFIG QFSDDRHCSR 240
  241 FRTLVAHYPP VQVLFEKGNL SKETKTILKS SLSCSLQEGL IPGSQFWDAS KTLRTLLEEE 300
  301 YFREKLSDGI GVMLPQVLKG MTSESDSIGL TPGEKSELAL SALGGCVFYL KKCLIDQELL 360
  361 SMANFEEYIP LDSDTVSTTR SGAIFTKAYQ RMVLDAVTLN NLEIFLNGTN GSTEGTLLER 420
  421 VDTCHTPFGK RLLKQWLCAP LCNHYAINDR LDAIEDLMVV PDKISEVVEL LKKLPDLERL 480
  481 LSKIHNVGSP LKSQNHPDSR AIMYEETTYS KKKIIDFLSA LEGFKVMCKI IGIMEEVADG 540
  541 FKSKILKQVI SLQTKNPEGR FPDLTVELNR WDTAFDHEKA RKTGLITPKA GFDSDYDQAL 600
  601 ADIRENEQSL LEYLEKQRNR IGCRTIVYWG IGRNRYQLEI PENFTTRNLP EEYELKSTKK 660
  661 GCKRYWTKTI EKKLANLINA EERRDVSLKD CMRRLFYNFD KNYKDWQSAV ECIAVLDVLL 720
  721 CLANYSRGGD GPMCRPVILL PEDTPPFLEL KGSRHPCITK TFFGDDFIPN DILIGCEEEE 780
  781 QENGKAYCVL VTGPNMGGKS TLMRQAGLLA VMAQMGCYVP AEVCRLTPID RVFTRLGASD 840
  841 RIMSGESTFF VELSETASIL MHATAHSLVL VDELGRGTAT FDGTAIANAV VKELAETIKC 900
  901 RTLFSTHYHS LVEDYSQNVA VRLGHMACMV ENECEDPSQE TITFLYKFIK GACPKSYGFN 960
  961 AARLANLPEE VIQKGHRKAR EFEKMNQSLR LFREVCLASE RSTVDAEAVH KLLTLIKEL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	2o8bB
Description:	No description for 2o8bB was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits