Protein Overview: PRPF6

General Information:
Name(s) found:	PRPF6 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|7658291\|gb\|AAF66128.1\|AF221842_1 U5 snRNP-associated 102 kDa protein [Homo sapiens] [NCBI NR] gi\|56203967\|emb\|CAI21906.1\| PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) [Homo sapiens] [NCBI NR] gi\|55958583\|emb\|CAC16610.2\| PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) [Homo sapiens] [NCBI NR] gi\|55664585\|emb\|CAH71582.1\| PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) [Homo sapiens] [NCBI NR] gi\|4164166\|dbj\|BAA37140.1\| unnamed protein product [Homo sapiens] [NCBI NR] gi\|40807485\|ref\|NP_036601.2\| PRP6 pre-mRNA processing factor 6 homolog [Homo sapiens] [NCBI NR] gi\|24212088\|sp\|O94906.1\|PRP6_HUMAN RecName: Full=Pre-mRNA-processing factor 6; AltName: Full=U5 snRNP-associated 102 kDa protein; Short=U5-102 kDa protein; AltName: Full=PRP6 homolog [NCBI NR] gi\|12804511\|gb\|AAH01666.1\| PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) [Homo sapiens] [NCBI NR] gi\|119595580\|gb\|EAW75174.1\| chromosome 20 open reading frame 14, isoform CRA_a [Homo sapiens] [NCBI NR] PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) [HGNC (HUGO)] (O94906) U5 snRNP-associated 102 kDa protein (U5-102 kDa protein) [Swiss-Prot] Pre-mRNA-processing factor 6 OS=Homo sapiens GN=PRPF6 PE=1 SV=1 [Swiss-Prot] U5 snRNP-associated 102 kDa protein [hmr_yeast5_DM3-1_pombe.fasta] U5 snRNP-associated 102 kDa protein; putative mitochondrial outer membrane protein import receptor; similar to yeast pre-mRNA splicing factors, Prp1/Zer and Prp6; androgen receptor N-terminal domain transactivating protein-1; p102 U5 small nuclear ribonuc [HMR_022704.fasta] U5 snRNP-associated 102 kDa protein; similar to yeast pre-mRNA splicing factors, Prp1/Zer and Prp6; androgen receptor N-terminal domain transactivating protein-1; p102 U5 small nuclear ribonucleoprotein particle-binding protein; putative mitochondrial out [Human2242005.fasta] U5 snRNP-associated 102 kDa protein [Homo sapiens]gi\|55664585\|emb\|CAH71582.1\| C20orf14 [Homo sapiens]gi\|12804511\|gb\|AAH01666.1\| U5 snRNP-associated 102 kDa protein [Homo sapiens]gi\|7658291\|gb\|AAF66128.1\| U5 snRNP-associated 102 kDa protein [Homo sapien [nrdb_11152004_Chlamydomonas] U5 snRNP-associated 102 kDa protein (U5-102 kDa protein) [Yateslab_human_na_07-28-2006_reversed.fasta] Tax_Id=9606 U5 snRNP-associated 102 kDa protein [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] PRP6 pre-mRNA processing factor 6 homolog [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] Pre-mRNA-processing factor 6 (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) (PRP6 homolog) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] chromosome 20 open reading frame 14, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] U5 snRNP-associated 102 kDa protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 Pre-mRNA-processing factor 6 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta] Tax_Id=9606 U5 SNRNP-ASSOCIATED 102 KDA PROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] RecName: Full=Pre-mRNA-processing factor 6; AltName: Full=U5 snRNP-associated 102 kDa protein; Short=U5-102 kDa protein; AltName: Full=PRP6 homolog [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=PRPF6 Pre-mRNA-processing factor 6 [human-ipi-250309-contam.fasta] Pre-mRNA-processing factor 6 homolog (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) [nr-271106-contam.fasta] C20orf14 [Homo sapiens] [nr-271106-contam.fasta] IPI:IPI00305068.5\|SWISS-PROT:O94906\|TREMBL:B2RAR5;B3KMC6\|ENSEMBL:ENSP00000266079\|REFSEQ:NP_036601\|H-INV:HIT000074377\|VEGA:OTTHUMP00000031625 Tax_Id=9606 Gene_Symbol=PRPF6 Pre-mRNA-processing factor 6 [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=PRPF6 Pre-mRNA-processing factor 6 ENSG00000101161 IPI00305068 [drosphohumanreversed.fasta] pre-mRNA-processing factor 6 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] O94906;O95109;Q5VXS5;Q9H3Z1;Q9H4T9;Q9H4U8;Q9NTE6; RecName: Full=Pre-mRNA-processing factor 6; AltName: Full=U5 snRNP-associated 102 kDa protein; AltName: Full=PRP6 homolog; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Pre-mRNA-processing factor 6 OS=Homo sapiens GN=PRPF6 [011711_HMR.fasta] Pre-mRNA-processing factor 6 n=23 Tax=Euteleostomi RepID=PRP6_HUMAN [UniProt_Xenopus_laevis_01-01-2011_reversed.fasta] GeneSymbol=PRPF6 Synonyms=ANT-1\|C20orf14\|Prp6\|TOM\|U5-102K\|hPrp6 pre-mRNA-processing factor 6 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] Pre-mRNA-processing factor 6 GN=PRPF6 [Doctor+uniprot-HUMAN-120911.fasta]
Organism:	Homo sapiens
Length:	941 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKKKKPFLG MPAPLGYVPG LGRGATGFTT RSDIGPARDA NDPVDDRHAP PGKRTVGDQM  60
   61 KKNQAADDDD EDLNDTNYDE FNGYAGSLFS SGPYEKDDEE ADAIYAALDK RMDERRKERR 120
  121 EQREKEEIEK YRMERPKIQQ QFSDLKRKLA EVTEEEWLSI PEVGDARNKR QRNPRYEKLT 180
  181 PVPDSFFAKH LQTGENHTSV DPRQTQFGGL NTPYPGGLNT PYPGGMTPGL MTPGTGELDM 240
  241 RKIGQARNTL MDMRLSQVSD SVSGQTVVDP KGYLTDLNSM IPTHGGDIND IKKARLLLKS 300
  301 VRETNPHHPP AWIASARLEE VTGKLQVARN LIMKGTEMCP KSEDVWLEAA RLQPGDTAKA 360
  361 VVAQAVRHLP QSVRIYIRAA ELETDIRAKK RVLRKALEHV PNSVRLWKAA VELEEPEDAR 420
  421 IMLSRAVECC PTSVELWLAL ARLETYENAR KVLNKARENI PTDRHIWITA AKLEEANGNT 480
  481 QMVEKIIDRA ITSLRANGVE INREQWIQDA EECDRAGSVA TCQAVMRAVI GIGIEEEDRK 540
  541 HTWMEDADSC VAHNALECAR AIYAYALQVF PSKKSVWLRA AYFEKNHGTR ESLEALLQRA 600
  601 VAHCPKAEVL WLMGAKSKWL AGDVPAARSI LALAFQANPN SEEIWLAAVK LESENDEYER 660
  661 ARRLLAKARS SAPTARVFMK SVKLEWVQDN IRAAQDLCEE ALRHYEDFPK LWMMKGQIEE 720
  721 QKEMMEKARE AYNQGLKKCP HSTPLWLLLS RLEEKIGQLT RARAILEKSR LKNPKNPGLW 780
  781 LESVRLEYRA GLKNIANTLM AKALQECPNS GILWSEAIFL EARPQRRTKS VDALKKCEHD 840
  841 PHVLLAVAKL FWSQRKITKA REWFHRTVKI DSDLGDAWAF FYKFELQHGT EEQQEEVRKR 900
  901 CESAEPRHGE LWCAVSKDIA NWQKKIGDIL RLVAGRIKNT F

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	gi\|14317902, gi\|...	No Comments	Cheeseman, I.M., et al. (2004)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..176]	Pfam	105.008774	No description for PF06424.3 was found. No confident structure predictions are available.
2	View Details	[177..221]	PSI-BLAST	9.0	No description for 2fi7A was found.
3	View Details	[222..740]	PSI-BLAST	16.30103	No description for 2gw1A was found.
4	View Details	[741..941]	PSI-BLAST	38.0	The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.

Protein Overview: PRPF6

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: