YRC Public Data Repository - Protein Structure Prediction

Protein:	PRPF6
Organism:	Homo sapiens
Length:	941 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRPF6.

Description	E-value	Query Range	Subject Range
gi\|73992767 - gi\|73992767\|ref\|XP_534481.2\| PREDICTED: similar to U5 snRNP-associated 102 kDa protein [Canis famili...	7.0E-97	[1..941]	[60..1000]
gi\|71895939, gi\|... - gi\|71895939\|ref\|NP_001025642.1\| MGC97740 protein [Xenopus (Silurana) tropicalis], gi\|60550964\|gb\|AAH...	9.0E-97	[1..941]	[33..972]
PRP6_RAT - Pre-mRNA-processing factor 6 OS=Rattus norvegicus GN=Prpf6 PE=1 SV=1	2.0E-96	[1..941]	[1..941]
PRP6_MOUSE - Pre-mRNA-processing factor 6 OS=Mus musculus GN=Prpf6 PE=1 SV=1	2.0E-96	[1..941]	[1..941]
gi\|157766600 - gi\|157766600\|ref\|XP_001675643.1\| Hypothetical protein CBG05596 [Caenorhabditis briggsae AF16] gi\|39585338, gi\|... - gi\|39585338\|emb\|CAE61660.1\| Hypothetical protein CBG05596 [Caenorhabditis briggsae], gi\|187034843\|em...	1.0E-95	[1..932]	[10..947]
gi\|55727663 - gi\|55727663\|emb\|CAH90585.1\| hypothetical protein [Pongo abelii] PRP6_PONAB - Pre-mRNA-processing factor 6 OS=Pongo abelii GN=PRPF6 PE=2 SV=1	3.0E-95	[1..941]	[1..941]
PRP6_BOVIN - Pre-mRNA-processing factor 6 OS=Bos taurus GN=PRPF6 PE=2 SV=1	7.0E-95	[1..941]	[1..941]
gi\|114683093 - gi\|114683093\|ref\|XP_001152053.1\| PREDICTED: hypothetical protein isoform 3 [Pan troglodytes]	1.0E-94	[1..941]	[1..941]
gi\|50927247, gi\|... - gi\|50927247\|gb\|AAH79686.1\| MGC80263 protein [Xenopus laevis], gi\|148222496\|ref\|NP_001087374.1\| MGC80...	1.0E-94	[1..941]	[9..948]

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Predicted Domain #1

Region A:
Residues: [1-176]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKKKKPFLG MPAPLGYVPG LGRGATGFTT RSDIGPARDA NDPVDDRHAP PGKRTVGDQM  60
   61 KKNQAADDDD EDLNDTNYDE FNGYAGSLFS SGPYEKDDEE ADAIYAALDK RMDERRKERR 120
  121 EQREKEEIEK YRMERPKIQQ QFSDLKRKLA EVTEEEWLSI PEVGDARNKR QRNPRY

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	105.008774
Match:	PF06424.3
Description:	No description for PF06424.3 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [177-221]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKLTPVPDSF FAKHLQTGEN HTSVDPRQTQ FGGLNTPYPG GLNTP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.0
Match:	2fi7A
Description:	No description for 2fi7A was found.

Predicted Domain #3

Region A:
Residues: [222-740]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPGGMTPGLM TPGTGELDMR KIGQARNTLM DMRLSQVSDS VSGQTVVDPK GYLTDLNSMI  60
   61 PTHGGDINDI KKARLLLKSV RETNPHHPPA WIASARLEEV TGKLQVARNL IMKGTEMCPK 120
  121 SEDVWLEAAR LQPGDTAKAV VAQAVRHLPQ SVRIYIRAAE LETDIRAKKR VLRKALEHVP 180
  181 NSVRLWKAAV ELEEPEDARI MLSRAVECCP TSVELWLALA RLETYENARK VLNKARENIP 240
  241 TDRHIWITAA KLEEANGNTQ MVEKIIDRAI TSLRANGVEI NREQWIQDAE ECDRAGSVAT 300
  301 CQAVMRAVIG IGIEEEDRKH TWMEDADSCV AHNALECARA IYAYALQVFP SKKSVWLRAA 360
  361 YFEKNHGTRE SLEALLQRAV AHCPKAEVLW LMGAKSKWLA GDVPAARSIL ALAFQANPNS 420
  421 EEIWLAAVKL ESENDEYERA RRLLAKARSS APTARVFMKS VKLEWVQDNI RAAQDLCEEA 480
  481 LRHYEDFPKL WMMKGQIEEQ KEMMEKAREA YNQGLKKCP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.30103
Match:	2gw1A
Description:	No description for 2gw1A was found.

Predicted Domain #4

Region A:
Residues: [741-941]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSTPLWLLLS RLEEKIGQLT RARAILEKSR LKNPKNPGLW LESVRLEYRA GLKNIANTLM  60
   61 AKALQECPNS GILWSEAIFL EARPQRRTKS VDALKKCEHD PHVLLAVAKL FWSQRKITKA 120
  121 REWFHRTVKI DSDLGDAWAF FYKFELQHGT EEQQEEVRKR CESAEPRHGE LWCAVSKDIA 180
  181 NWQKKIGDIL RLVAGRIKNT F

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.0
Match:	1w3bA
Description:	The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits