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Protein Overview: PHGDH

General Information:
Name(s) found: PHGDH [HGNC (HUGO)]
Description(s) found:
Found 36 descriptions.
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  • phosphoglycerate dehydrogenase [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 533 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFANLRKVL ISDSLDPCCR KILQDGGLQV VEKQNLSKEE LIAELQDCEG LIVRSATKVT  60
   61 ADVINAAEKL QVVGRAGTGV DNVDLEAATR KGILVMNTPN GNSLSAAELT CGMIMCLARQ 120
  121 IPQATASMKD GKWERKKFMG TELNGKTLGI LGLGRIGREV ATRMQSFGMK TIGYDPIISP 180
  181 EVSASFGVQQ LPLEEIWPLC DFITVHTPLL PSTTGLLNDN TFAQCKKGVR VVNCARGGIV 240
  241 DEGALLRALQ SGQCAGAALD VFTEEPPRDR ALVDHENVIS CPHLGASTKE AQSRCGEEIA 300
  301 VQFVDMVKGK SLTGVVNAQA LTSAFSPHTK PWIGLAEALG TLMRAWAGSP KGTIQVITQG 360
  361 TSLKNAGNCL SPAVIVGLLK EASKQADVNL VNAKLLVKEA GLNVTTSHSP AAPGEQGFGE 420
  421 CLLAVALAGA PYQAVGLVQG TTPVLQGLNG AVFRPEVPLR RDLPLLLFRT QTSDPAMLPT 480
  481 MIGLLAEAGV RLLSYQTSLV SDGETWHVMG ISSLLPSLEA WKQHVTEAFQ FHF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..325] PSI-BLAST 98.0 No description for 2g76A was found.
    2 View Details [326..533] FFAS03 3.76 Crystal Structure of D-3-Phosphoglycerate dehydrogenase From Mycobacterium tuberculosis

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • acetolactate synthase activity
    		•  2.87535131873671 bayes_pls_golite062009
  • binding
    		•  2.47964181280228 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.43081962448069 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.7797781976147 bayes_pls_golite062009
  • ammonia-lyase activity
    		•  1.74510205602239 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  1.67131308363643 bayes_pls_golite062009
  • catalytic activity
    		•  1.6566335039519 bayes_pls_golite062009
  • DNA binding
    		•  1.64242047340311 bayes_pls_golite062009
  • carbon-nitrogen lyase activity
    		•  1.56855124679856 bayes_pls_golite062009
  • L-serine ammonia-lyase activity
    		•  1.38716609835752 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08862696602076 bayes_pls_golite062009
  • lyase activity
    		•  0.968092820405931 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.481180403604313 bayes_pls_golite062009
  • transferase activity
    		•  0.446188170117088 bayes_pls_golite062009
  • protein binding
    		•  0.312183106484467 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle