Protein Overview: PARL

General Information:
Name(s) found:	PARL [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|20127652\|ref\|NP_061092.3\| presenilin associated, rhomboid-like isoform 1 preproprotein [Homo sapiens] [NCBI NR] gi\|15559382\|gb\|AAH14058.1\| Presenilin associated, rhomboid-like [Homo sapiens] [NCBI NR] gi\|143811433\|sp\|Q9H300.2\|PARL_HUMAN RecName: Full=Presenilins-associated rhomboid-like protein, mitochondrial; AltName: Full=Mitochondrial intramembrane cleaving protease PARL; Contains: RecName: Full=P-beta; Short=Pbeta; Flags: Precursor [NCBI NR] gi\|119598718\|gb\|EAW78312.1\| presenilin associated, rhomboid-like, isoform CRA_b [Homo sapiens] [NCBI NR] presenilin associated, rhomboid-like [HGNC (HUGO)] Presenilins-associated rhomboid-like protein, mitochondrial OS=Homo sapiens GN=PARL PE=1 SV=2 [Swiss-Prot] Presenilins associated rhomboid-like protein [hmr_yeast5_DM3-1_pombe.fasta] presenilin associated, rhomboid-like [Homo sapiens]gi\|15559382\|gb\|AAH14058.1\| Presenilin associated, rhomboid-like [Homo sapiens] [nrdb_11152004_Chlamydomonas] (NM_018622) presenilins associated rhomboid-like protein; hypothetical protein PRO2207 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] presenilin associated, rhomboid-like isoform 1 preproprotein [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] Tax_Id=9606 Rhomboid-like protein family protein [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta] Tax_Id=9606 Presenilin associated, rhomboid-like [EBI-IPI_human_3.04_03-07-2005_reverse.fasta] presenilin associated, rhomboid-like [Homo sapiens] [HumanGallus06162005.fasta] Presenilins-associated rhomboid-like protein, mitochondrial precursor (Mitochondrial intramembrane cleaving protease PARL) [Contains: P-beta (Pbeta)] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] presenilin associated, rhomboid-like, isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Presenilin associated, rhomboid-like [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 PRESENILIN ASSOCIATED, RHOMBOID-LIKE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] RecName: Full=Presenilins-associated rhomboid-like protein, mitochondrial; AltName: Full=Mitochondrial intramembrane cleaving protease PARL; Contains: RecName: Full=P-beta; Short=Pbeta; Flags: Precursor [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=PARL Isoform 1 of Presenilins-associated rhomboid-like protein, mitochondrial [human-ipi-250309-contam.fasta] IPI:IPI00060545.5\|SWISS-PROT:Q9H300-1\|ENSEMBL:ENSP00000325421\|REFSEQ:NP_061092\|H-INV:HIT000008039\|VEGA:OTTHUMP00000173760;OTTHUMP00000210934 Tax_Id=9606 Gene_Symbol=PARL Isoform 1 of Presenilins-associated rhomboid-like protein, mitochondrial [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=PARL Isoform 1 of Presenilins-associated rhomboid-like protein, mitochondrial precursor ENSG00000175193 IPI00186189 IPI00060545 IPI00790788 IPI00788780 IPI00796717 IPI00793963 IPI00795020 IPI00792785 [drosphohumanreversed.fasta] Tax_Id=9606 Gene_Symbol=PARL Isoform 1 of Presenilins-associated rhomboid-like protein, mitochondrial precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta] presenilins-associated rhomboid-like protein, mitochondrial isoform 1 preproprotein [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Q9H300;Q96CQ4;Q9BTJ6;Q9P1E3; RecName: Full=Presenilins-associated rhomboid-like protein, mitochondrial; AltName: Full=Mitochondrial intramembrane cleaving protease PARL; Contains: RecName: Full=P-beta; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Isoform 1 of Presenilins-associated rhomboid-like protein, mitochondrial OS=Homo sapiens GN=PARL [011711_HMR.fasta] GeneSymbol=PARL Synonyms=PSARL\|PSARL1\|PSENIP2\|RHBDS1 presenilins-associated rhomboid-like protein, mitochondrial isoform 1 preproprotein [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] IPI:IPI00060545.5\|SWISS-PROT:Q9H300-1\|ENSEMBL:ENSP00000325421\|REFSEQ:NP_061092\|H-INV:HIT000008039\|VEGA:OTTHUMP00000210934 Tax_Id=9606 Gene_Symbol=PARL Isoform 1 of Presenilins-associated rhomboid-like protein, mitochondrial [ipi.HUMAN.20110912.fasta] Presenilins-associated rhomboid-like protein, mitochondrial GN=PARL [Doctor+uniprot-HUMAN-120911.fasta]
Organism:	Homo sapiens
Length:	379 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAWRGWAQRG WGCGQAWGAS VGGRSCEELT AVLTPPQLLG RRFNFFIQQK CGFRKAPRKV  60
   61 EPRRSDPGTS GEAYKRSALI PPVEETVFYP SPYPIRSLIK PLFFTVGFTG CAFGSAAIWQ 120
  121 YESLKSRVQS YFDGIKADWL DSIRPQKEGD FRKEINKWWN NLSDGQRTVT GIIAANVLVF 180
  181 CLWRVPSLQR TMIRYFTSNP ASKVLCSPML LSTFSHFSLF HMAANMYVLW SFSSSIVNIL 240
  241 GQEQFMAVYL SAGVISNFVS YVGKVATGRY GPSLGASGAI MTVLAAVCTK IPEGRLAIIF 300
  301 LPMFTFTAGN ALKAIIAMDT AGMILGWKFF DHAAHLGGAL FGIWYVTYGH ELIWKNREPL 360
  361 VKIWHEIRTN GPKKGGGSK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..161]	MSA	1.637933	View MSA. No confident structure predictions are available.
2	View Details	[162..379]	PSI-BLAST	26.0	No description for 2ic8A was found.

Protein Overview: PARL

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: