YRC Public Data Repository - Protein Structure Prediction

Protein:	PARL
Organism:	Homo sapiens
Length:	379 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PARL.

Description	E-value	Query Range	Subject Range
PARL - presenilin associated, rhomboid-like	0.0	[1..379]	[1..379]
gi\|114590628 - gi\|114590628\|ref\|XP_001135897.1\| PREDICTED: presenilin associated, rhomboid-like isoform 4 [Pan trog...	0.0	[1..379]	[1..379]
PARL_PONPY, PSAR... - (Q5R5H4) Presenilins-associated rhomboid-like protein, mitochondrial precursor (EC 3.4.21.105) (Mito... PARL_PONAB - Presenilins-associated rhomboid-like protein, mitochondrial OS=Pongo abelii GN=PARL PE=2 SV=1	0.0	[1..379]	[1..379]
gi\|90083314 - gi\|90083314\|dbj\|BAE90739.1\| unnamed protein product [Macaca fascicularis] gi\|109042951 - gi\|109042951\|ref\|XP_001105563.1\| PREDICTED: similar to presenilin associated, rhomboid-like isoform ...	0.0	[1..379]	[1..379]
gi\|74003236 - gi\|74003236\|ref\|XP_545224.2\| PREDICTED: similar to presenilin associated, rhomboid-like isoform 2 [C...	0.0	[1..379]	[1..379]
gi\|51980364 - gb\|AAH82182.1\| Unknown (protein for MGC:98644) [Xenopus laevis] PARL_MOUSE - Presenilins-associated rhomboid-like protein, mitochondrial OS=Mus musculus GN=Parl PE=1 SV=1	0.0	[1..379]	[1..377]
PARL_RAT - Presenilins-associated rhomboid-like protein, mitochondrial OS=Rattus norvegicus GN=Parl PE=2 SV=1	0.0	[1..379]	[1..377]
PARL_BOVIN - Presenilins-associated rhomboid-like protein, mitochondrial OS=Bos taurus GN=PARL PE=2 SV=1	0.0	[1..379]	[1..377]

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Predicted Domain #1

Region A:
Residues: [1-161]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAWRGWAQRG WGCGQAWGAS VGGRSCEELT AVLTPPQLLG RRFNFFIQQK CGFRKAPRKV  60
   61 EPRRSDPGTS GEAYKRSALI PPVEETVFYP SPYPIRSLIK PLFFTVGFTG CAFGSAAIWQ 120
  121 YESLKSRVQS YFDGIKADWL DSIRPQKEGD FRKEINKWWN N

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [162-379]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSDGQRTVTG IIAANVLVFC LWRVPSLQRT MIRYFTSNPA SKVLCSPMLL STFSHFSLFH  60
   61 MAANMYVLWS FSSSIVNILG QEQFMAVYLS AGVISNFVSY VGKVATGRYG PSLGASGAIM 120
  121 TVLAAVCTKI PEGRLAIIFL PMFTFTAGNA LKAIIAMDTA GMILGWKFFD HAAHLGGALF 180
  181 GIWYVTYGHE LIWKNREPLV KIWHEIRTNG PKKGGGSK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	26.0
Match:	2ic8A
Description:	No description for 2ic8A was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits