YRC Public Data Repository - Protein Structure Prediction

Protein:	PARL
Organism:	Homo sapiens
Length:	379 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PARL.

Description	E-value	Query Range	Subject Range
PARL - presenilin associated, rhomboid-like	0.0	[1..379]	[1..379]
gi\|114590628 - gi\|114590628\|ref\|XP_001135897.1\| PREDICTED: presenilin associated, rhomboid-like isoform 4 [Pan trog...	0.0	[1..379]	[1..379]
PARL_PONPY, PSAR... - (Q5R5H4) Presenilins-associated rhomboid-like protein, mitochondrial precursor (EC 3.4.21.105) (Mito... PARL_PONAB - Presenilins-associated rhomboid-like protein, mitochondrial OS=Pongo abelii GN=PARL PE=2 SV=1	0.0	[1..379]	[1..379]
gi\|90083314 - gi\|90083314\|dbj\|BAE90739.1\| unnamed protein product [Macaca fascicularis] gi\|109042951 - gi\|109042951\|ref\|XP_001105563.1\| PREDICTED: similar to presenilin associated, rhomboid-like isoform ...	0.0	[1..379]	[1..379]
gi\|74003236 - gi\|74003236\|ref\|XP_545224.2\| PREDICTED: similar to presenilin associated, rhomboid-like isoform 2 [C...	0.0	[1..379]	[1..379]
gi\|51980364 - gb\|AAH82182.1\| Unknown (protein for MGC:98644) [Xenopus laevis] PARL_MOUSE - Presenilins-associated rhomboid-like protein, mitochondrial OS=Mus musculus GN=Parl PE=1 SV=1	0.0	[1..379]	[1..377]
PARL_RAT - Presenilins-associated rhomboid-like protein, mitochondrial OS=Rattus norvegicus GN=Parl PE=2 SV=1	0.0	[1..379]	[1..377]
PARL_BOVIN - Presenilins-associated rhomboid-like protein, mitochondrial OS=Bos taurus GN=PARL PE=2 SV=1	0.0	[1..379]	[1..377]

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Predicted Domain #1

Region A:
Residues: [1-161]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAWRGWAQRG WGCGQAWGAS VGGRSCEELT AVLTPPQLLG RRFNFFIQQK CGFRKAPRKV  60
   61 EPRRSDPGTS GEAYKRSALI PPVEETVFYP SPYPIRSLIK PLFFTVGFTG CAFGSAAIWQ 120
  121 YESLKSRVQS YFDGIKADWL DSIRPQKEGD FRKEINKWWN N

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.266	N/A	N/A	a.141.1	Frizzled cystein-rich domain

Predicted Domain #2

Region A:
Residues: [162-379]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSDGQRTVTG IIAANVLVFC LWRVPSLQRT MIRYFTSNPA SKVLCSPMLL STFSHFSLFH  60
   61 MAANMYVLWS FSSSIVNILG QEQFMAVYLS AGVISNFVSY VGKVATGRYG PSLGASGAIM 120
  121 TVLAAVCTKI PEGRLAIIFL PMFTFTAGNA LKAIIAMDTA GMILGWKFFD HAAHLGGALF 180
  181 GIWYVTYGHE LIWKNREPLV KIWHEIRTNG PKKGGGSK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	26.0
Match:	2ic8A
Description:	No description for 2ic8A was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits