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Protein Overview: PLEKHF2

General Information:
Name(s) found: PLEKHF2 [HGNC (HUGO)]
Description(s) found:
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  • gi|74762744|sp|Q9H8W4.1|PKHF2_HUMAN RecName: Full=Pleckstrin homology domain-containing family F member 2; Short=PH domain-containing family F member 2; AltName: Full=PH and FYVE domain-containing protein 2; Short=Phafin-2; AltName: Full=Zinc finger FYVE [NCBI NR]
  • gi|21740242|emb|CAD39132.1| hypothetical protein [Homo sapiens] [NCBI NR]
  • gi|16904140|gb|AAL30774.1|AF434819_1 phafin 2 [Homo sapiens] [NCBI NR]
  • gi|15080049|gb|AAH11806.1| Pleckstrin homology domain containing, family F (with FYVE domain) member 2 [Homo sapiens] [NCBI NR]
  • gi|13375827|ref|NP_078889.1| phafin 2 [Homo sapiens] [NCBI NR]
  • gi|119612149|gb|EAW91743.1| pleckstrin homology domain containing, family F (with FYVE domain) member 2 [Homo sapiens] [NCBI NR]
  • gi|10435096|dbj|BAB14486.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • pleckstrin homology domain containing, family F (with FYVE domain) member 2 [HGNC (HUGO)]
  • Pleckstrin homology domain-containing family F member 2 OS=Homo sapiens GN=PLEKHF2 PE=1 SV=1 [Swiss-Prot]
  • Hypothetical protein FLJ13187 [hmr_yeast5_DM3-1_pombe.fasta]
  • phafin 2; PH and FYVE domain-containing protein 2 [HMR_022704.fasta]
  • PREDICTED: similar to phafin 2; PH and FYVE domain-containing protein 2 [Pan troglodytes]gi|13375827|ref|NP_078889.1| phafin 2 [Homo sapiens]gi|10435096|dbj|BAB14486.1| unnamed protein product [Homo sapiens]gi|15080049|gb|AAH11806.1| Phafin 2 [Homo sap [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 CDNA FLJ13187 fis, clone NT2RP3004242, weakly similar to PUTATIVE RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_024613) phafin 2; PH And FYVE domain-containing protein 2 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • phafin 2 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Hypothetical protein FLJ13187 [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta]
  • phafin 2; PH and FYVE domain-containing protein 2 [Homo sapiens] [HumanGallus06162005.fasta]
  • Pleckstrin homology domain-containing family F member 2 (PH domain-containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • pleckstrin homology domain containing, family F (with FYVE domain) member 2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Pleckstrin homology domain containing, family F (with FYVE domain) member 2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • hypothetical protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Pleckstrin homology domain-containing family F member 2 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 HYPOTHETICAL PROTEIN FLJ13187 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PLEKHF2 Pleckstrin homology domain-containing family F member 2 [human-ipi-250309-contam.fasta]
  • IPI:IPI00002424.1|SWISS-PROT:Q9H8W4|ENSEMBL:ENSP00000322373|REFSEQ:NP_078889|H-INV:HIT000029203|VEGA:OTTHUMP00000177917 Tax_Id=9606 Gene_Symbol=PLEKHF2 Pleckstrin homology domain-containing family F member 2 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=PLEKHF2 Pleckstrin homology domain-containing family F member 2 ENSG00000175895 IPI00002424 [drosphohumanreversed.fasta]
  • pleckstrin homology domain-containing family F member 2 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q9H8W4; RecName: Full=Pleckstrin homology domain-containing family F member 2; AltName: Full=PH and FYVE domain-containing protein 2; AltName: Full=Phafin-2; AltName: Full=Zinc finger FYVE domain-containing protein 18; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Pleckstrin homology domain-containing family F member 2 OS=Homo sapiens GN=PLEKHF2 [011711_HMR.fasta]
  • GeneSymbol=PLEKHF2 Synonyms=FLJ13187|PHAFIN2|ZFYVE18 pleckstrin homology domain-containing family F member 2 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00002424.1|SWISS-PROT:Q9H8W4|ENSEMBL:ENSP00000322373;ENSP00000427792|REFSEQ:NP_078889|H-INV:HIT000029203|VEGA:OTTHUMP00000227182;OTTHUMP00000227183 Tax_Id=9606 Gene_Symbol=PLEKHF2 Pleckstrin homology domain-containing family F member 2 [ipi.HUMAN.20110912.fasta]
  • Pleckstrin homology domain-containing family F member 2 GN=PLEKHF2 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 249 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDRLANSEA NTRRISIVEN CFGAAGQPLT IPGRVLIGEG VLTKLCRKKP KARQFFLFND  60
   61 ILVYGNIVIQ KKKYNKQHII PLENVTIDSI KDEGDLRNGW LIKTPTKSFA VYAATATEKS 120
  121 EWMNHINKCV TDLLSKSGKT PSNEHAAVWV PDSEATVCMR CQKAKFTPVN RRHHCRKCGF 180
  181 VVCGPCSEKR FLLPSQSSKP VRICDFCYDL LSAGDMATCQ PARSDSYSQS LKSPLNDMSD 240
  241 DDDDDDSSD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..73] PSI-BLAST 14.0 PLECKSTRIN HOMOLOGY DOMAIN OF SON OF SEVENLESS 1 (SOS1) WITH GLYCINE-SERINE ADDED TO THE N-TERMINUS, NMR, 20 STRUCTURES
    2 View Details [74..249] PSI-BLAST 16.0 Hrs

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.15122802029718 bayes_pls_golite062009
  • clathrin binding
    		•  0.856903790688531 bayes_pls_golite062009
  • protein binding
    		•  0.31144962654821 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle