YRC Public Data Repository - Protein Structure Prediction

Protein:	PLEKHF2
Organism:	Homo sapiens
Length:	249 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PLEKHF2.

Description	E-value	Query Range	Subject Range
PKHF2_MOUSE - Pleckstrin homology domain-containing family F member 2 OS=Mus musculus GN=Plekhf2 PE=1 SV=1	4.0E-49	[1..236]	[1..236]
gi\|109476116, gi... - gi\|34866158\|ref\|XP_342804.1\| PREDICTED: similar to Phafin 2 [Rattus norvegicus], gi\|171847385\|gb\|AAI...	6.0E-49	[1..236]	[1..236]
gi\|62901986 - gi\|62901986\|gb\|AAY18944.1\| DKFZp762A0711 [synthetic construct]	8.0E-49	[2..236]	[26..260]
PKHF2_CHICK - Pleckstrin homology domain-containing family F member 2 OS=Gallus gallus GN=PLEKHF2 PE=2 SV=1	8.0E-46	[1..232]	[1..232]
gi\|220949950, gi... - gi\|220959106\|gb\|ACL92096.1\| CG14782-PA [synthetic construct], gi\|220949950\|gb\|ACL87518.1\| CG14782-PA... FBpp0308661, CG1... - This gene is referred to in FlyBase by the symbol Dmel\CG14782 (CG14782, FBgn0025381). It is a prote...	1.0E-45	[1..248]	[1..253]
gi\|125983332, gi... - gi\|54643746\|gb\|EAL32489.1\| GA13242 [Drosophila pseudoobscura pseudoobscura], gi\|125983332\|ref\|XP_001... gi\|54643746\|gb\|E... - GA13242-PA [Drosophila pseudoobscura], GA13242 [Drosophila pseudoobscura pseudoobscura]	2.0E-45	[1..249]	[1..250]
gi\|62859343 - gi\|62859343\|ref\|NP_001016121.1\| hypothetical protein LOC548875 [Xenopus (Silurana) tropicalis]	3.0E-45	[1..236]	[1..236]
PKHF2_DANRE - Pleckstrin homology domain-containing family F member 2 OS=Danio rerio GN=plekhf2 PE=2 SV=1	5.0E-44	[1..234]	[1..234]
gi\|91087327 - gi\|91087327\|ref\|XP_975593.1\| PREDICTED: similar to FYVE finger containing protein [Tribolium castane...	1.0E-43	[1..226]	[1..226]
gi\|58386265, gi\|... - gi\|58386265\|ref\|XP_314634.2\| ENSANGP00000000661 [Anopheles gambiae str. PEST], gi\|55240031\|gb\|EAA100...	2.0E-43	[1..213]	[1..213]

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Predicted Domain #1

Region A:
Residues: [1-73]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDRLANSEA NTRRISIVEN CFGAAGQPLT IPGRVLIGEG VLTKLCRKKP KARQFFLFND  60
   61 ILVYGNIVIQ KKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.0
Match:	1pmsA
Description:	PLECKSTRIN HOMOLOGY DOMAIN OF SON OF SEVENLESS 1 (SOS1) WITH GLYCINE-SERINE ADDED TO THE N-TERMINUS, NMR, 20 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [74-249]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YNKQHIIPLE NVTIDSIKDE GDLRNGWLIK TPTKSFAVYA ATATEKSEWM NHINKCVTDL  60
   61 LSKSGKTPSN EHAAVWVPDS EATVCMRCQK AKFTPVNRRH HCRKCGFVVC GPCSEKRFLL 120
  121 PSQSSKPVRI CDFCYDLLSA GDMATCQPAR SDSYSQSLKS PLNDMSDDDD DDDSSD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.0
Match:	1dvpA
Description:	Hrs
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.15122802029718	bayes_pls_golite062009
clathrin binding	0.856903790688531	bayes_pls_golite062009
protein binding	0.31144962654821	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: