Protein Overview: EXOSC10

General Information:
Name(s) found:	EXOSC10 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|8928564\|sp\|Q01780.2\|EXOSX_HUMAN RecName: Full=Exosome component 10; AltName: Full=Polymyositis/scleroderma autoantigen 2; AltName: Full=Autoantigen PM/Scl 2; AltName: Full=Polymyositis/scleroderma autoantigen 100 kDa; Short=PM/Scl-100; AltName: Full=P1 [NCBI NR] gi\|56204112\|emb\|CAI22107.1\| exosome component 10 [Homo sapiens] [NCBI NR] gi\|50301240\|ref\|NP_001001998.1\| exosome component 10 isoform 1 [Homo sapiens] [NCBI NR] gi\|49257470\|gb\|AAH73788.1\| Exosome component 10 [Homo sapiens] [NCBI NR] gi\|35555\|emb\|CAA46904.1\| PM/Scl 100kD nucleolar protein [Homo sapiens] [NCBI NR] pir\|\|JH0796 nucleolar 100K polymyositis-scleroderma protein - human [NCBI NR] gi\|25140242\|gb\|AAH39901.1\| Exosome component 10 [Homo sapiens] [NCBI NR] gi\|119592085\|gb\|EAW71679.1\| exosome component 10, isoform CRA_c [Homo sapiens] [NCBI NR] exosome component 10 [HGNC (HUGO)] (Q01780) Polymyositis/scleroderma autoantigen 2 (Exosome component 10) (Autoantigen PM/Scl 2) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (P100 polymyositis-scleroderma overlap syndrome associated autoantigen) [Swiss-Prot] Exosome component 10 OS=Homo sapiens GN=EXOSC10 PE=1 SV=2 [Swiss-Prot] Splice isoform 1 of Q01780 [hmr_yeast5_DM3-1_pombe.fasta] polymyositis/scleroderma autoantigen 2 (100kD) [HMR_022704.fasta] exosome component 10 isoform 1; autoantigen PM-SCL; polymyositis/scleroderma autoantigen 2 (100kD); polymyositis/scleroderma autoantigen 2, 100kDa [071204_hmrz_cont.fasta] exosome component 10 isoform 1 [Homo sapiens]gi\|49257470\|gb\|AAH73788.1\| Exosome component 10, isoform 1 [Homo sapiens]gi\|25140242\|gb\|AAH39901.1\| Exosome component 10, isoform 1 [Homo sapiens]gi\|35555\|emb\|CAA46904.1\| PM/Scl 100kD nucleolar protein [Homo [nrdb_11152004_Chlamydomonas] Exosome component 10 (Polymyositis/scleroderma autoantigen 2) (Autoantigen PM/Scl 2) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (P100 polymyositis-scleroderma overlap syndrome associated autoantigen) [Yateslab_human_na_07-28-2006_reversed.fasta] Tax_Id=9606 Splice Isoform 1 of Exosome component 10 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] exosome component 10 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] Exosome component 10 (Polymyositis/scleroderma autoantigen 2) (Autoantigen PM/Scl 2) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] exosome component 10 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] exosome component 10, isoform CRA_c [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Exosome component 10 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] PM/Scl 100kD nucleolar protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 Isoform 1 of Exosome component 10 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta] Tax_Id=9606 SPLICE ISOFORM 1 OF POLYMYOSITIS/SCLERODERMA AUTOANTIGEN 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] RecName: Full=Exosome component 10; AltName: Full=Polymyositis/scleroderma autoantigen 2; AltName: Full=Autoantigen PM/Scl 2; AltName: Full=Polymyositis/scleroderma autoantigen 100 kDa; Short=PM/Scl-100; AltName: Full=P100 polymyositis-scleroderma overlap [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=EXOSC10 Isoform 1 of Exosome component 10 [human-ipi-250309-contam.fasta] polymyositis/scleroderma autoantigen 2, 100kDa [Homo sapiens] [nr-271106-contam.fasta] IPI:IPI00009464.1\|SWISS-PROT:Q01780-1\|TREMBL:B1AKQ0\|ENSEMBL:ENSP00000366135\|REFSEQ:NP_001001998\|H-INV:HIT000265014\|VEGA:OTTHUMP00000002176 Tax_Id=9606 Gene_Symbol=EXOSC10 Isoform 1 of Exosome component 10 [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=EXOSC10 Isoform 1 of Exosome component 10 ENSG00000171824 IPI00220336 IPI00009464 IPI00815844 [drosphohumanreversed.fasta] Q01780;B1AKQ0;B1AKQ1;Q15158; RecName: Full=Exosome component 10; AltName: Full=Polymyositis/scleroderma autoantigen 2; AltName: Full=Autoantigen PM/Scl 2; AltName: Full=Polymyositis/scleroderma autoantigen 100 kDa; AltName: Full=P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Isoform 1 of Exosome component 10 OS=Homo sapiens GN=EXOSC10 [011711_HMR.fasta] IPI:IPI00009464.1\|SWISS-PROT:Q01780-1\|ENSEMBL:ENSP00000366135\|REFSEQ:NP_001001998\|H-INV:HIT000265014\|VEGA:OTTHUMP00000002176 Tax_Id=9606 Gene_Symbol=EXOSC10 Isoform 1 of Exosome component 10 [ipi.HUMAN.fasta.20100406] GeneSymbol=EXOSC10 Synonyms=PM-Scl\|PM/Scl-100\|PMSCL\|PMSCL2\|RRP6\|Rrp6p\|p2\|p3\|p4 exosome component 10 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] Exosome component 10 GN=EXOSC10 [Doctor+uniprot-HUMAN-120911.fasta]
Organism:	Homo sapiens
Length:	885 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPPSTREPR VLSATSATKS DGEMVLPGFP DADSFVKFAL GSVVAVTKAS GGLPQFGDEY  60
   61 DFYRSFPGFQ AFCETQGDRL LQCMSRVMQY HGCRSNIKDR SKVTELEDKF DLLVDANDVI 120
  121 LERVGILLDE ASGVNKNQQP VLPAGLQVPK TVVSSWNRKA AEYGKKAKSE TFRLLHAKNI 180
  181 IRPQLKFREK IDNSNTPFLP KIFIKPNAQK PLPQALSKER RERPQDRPED LDVPPALADF 240
  241 IHQQRTQQVE QDMFAHPYQY ELNHFTPADA VLQKPQPQLY RPIEETPCHF ISSLDELVEL 300
  301 NEKLLNCQEF AVDLEHHSYR SFLGLTCLMQ ISTRTEDFII DTLELRSDMY ILNESLTDPA 360
  361 IVKVFHGADS DIEWLQKDFG LYVVNMFDTH QAARLLNLGR HSLDHLLKLY CNVDSNKQYQ 420
  421 LADWRIRPLP EEMLSYARDD THYLLYIYDK MRLEMWERGN GQPVQLQVVW QRSRDICLKK 480
  481 FIKPIFTDES YLELYRKQKK HLNTQQLTAF QLLFAWRDKT ARREDESYGY VLPNHMMLKI 540
  541 AEELPKEPQG IIACCNPVPP LVRQQINEMH LLIQQAREMP LLKSEVAAGV KKSGPLPSAE 600
  601 RLENVLFGPH DCSHAPPDGY PIIPTSGSVP VQKQASLFPD EKEDNLLGTT CLIATAVITL 660
  661 FNEPSAEDSK KGPLTVAQKK AQNIMESFEN PFRMFLPSLG HRAPVSQAAK FDPSTKIYEI 720
  721 SNRWKLAQVQ VQKDSKEAVK KKAAEQTAAR EQAKEACKAA AEQAISVRQQ VVLENAAKKR 780
  781 ERATSDPRTT EQKQEKKRLK ISKKPKDPEP PEKEFTPYDY SQSDFKAFAG NSKSKVSSQF 840
  841 DPNKQTPSGK KCIAAKKIKQ SVGNKSMSFP TGKSDRGFRY NWPQR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..179]	PSI-BLAST	24.69897	Divalent metal ions (manganese) bound to T5 5'-exonuclease
2	View Details	[180..586]	PSI-BLAST	53.30103	No description for 2hbjA was found.
3	View Details	[587..733]	PSI-BLAST	50.69897	Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
4	View Details	[734..885]	MSA	12.260997	View MSA. No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.92

Protein Overview: EXOSC10

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: