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View Structure Prediction Details

Protein: EXOSC10
Organism: Homo sapiens
Length: 885 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EXOSC10.

Description E-value Query
Range
Subject
Range
EXOSX_MOUSE, PMC... - (P56960) Polymyositis/scleroderma autoantigen 100 kDa (Exosome component 10) (Autoantigen PM/Scl 2) ...
0.0 [1..885] [1..887]
gi|114553916, gi... - gi|114553918|ref|XP_001136533.1| PREDICTED: exosome component 10 isoform 4 [Pan troglodytes], gi|114...
0.0 [1..885] [1..885]
gi|108997023, gi... - gi|108997029|ref|XP_001103741.1| PREDICTED: similar to exosome component 10 isoform 1 isoform 4 [Mac...
0.0 [1..885] [1..884]
gi|73950874 - gi|73950874|ref|XP_535408.2| PREDICTED: similar to exosome component 10 isoform 1 [Canis familiaris]
0.0 [38..885] [164..1012]
gi|56204111, gi|... - gi|56204111|emb|CAI22106.1| exosome component 10 [Homo sapiens], gi|4505917|ref|NP_002676.1| exosome...
0.0 [1..885] [1..860]
gi|76637212 - gi|76637212|ref|XP_615399.2| PREDICTED: similar to PM/Scl 100kD nucleolar protein isoform 1 [Bos tau...
0.0 [1..885] [1..887]

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Predicted Domain #1
Region A:
Residues: [1-179]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPPSTREPR VLSATSATKS DGEMVLPGFP DADSFVKFAL GSVVAVTKAS GGLPQFGDEY  60
   61 DFYRSFPGFQ AFCETQGDRL LQCMSRVMQY HGCRSNIKDR SKVTELEDKF DLLVDANDVI 120
  121 LERVGILLDE ASGVNKNQQP VLPAGLQVPK TVVSSWNRKA AEYGKKAKSE TFRLLHAKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.69897
Match: 1ut5A
Description: Divalent metal ions (manganese) bound to T5 5'-exonuclease
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 0.0362350320953433 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [180-586]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IIRPQLKFRE KIDNSNTPFL PKIFIKPNAQ KPLPQALSKE RRERPQDRPE DLDVPPALAD  60
   61 FIHQQRTQQV EQDMFAHPYQ YELNHFTPAD AVLQKPQPQL YRPIEETPCH FISSLDELVE 120
  121 LNEKLLNCQE FAVDLEHHSY RSFLGLTCLM QISTRTEDFI IDTLELRSDM YILNESLTDP 180
  181 AIVKVFHGAD SDIEWLQKDF GLYVVNMFDT HQAARLLNLG RHSLDHLLKL YCNVDSNKQY 240
  241 QLADWRIRPL PEEMLSYARD DTHYLLYIYD KMRLEMWERG NGQPVQLQVV WQRSRDICLK 300
  301 KFIKPIFTDE SYLELYRKQK KHLNTQQLTA FQLLFAWRDK TARREDESYG YVLPNHMMLK 360
  361 IAEELPKEPQ GIIACCNPVP PLVRQQINEM HLLIQQAREM PLLKSEV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.30103
Match: 2hbjA
Description: No description for 2hbjA was found.

Predicted Domain #3
Region A:
Residues: [587-733]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAGVKKSGPL PSAERLENVL FGPHDCSHAP PDGYPIIPTS GSVPVQKQAS LFPDEKEDNL  60
   61 LGTTCLIATA VITLFNEPSA EDSKKGPLTV AQKKAQNIME SFENPFRMFL PSLGHRAPVS 120
  121 QAAKFDPSTK IYEISNRWKL AQVQVQK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.69897
Match: 1qtmA
Description: Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [734-885]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSKEAVKKKA AEQTAAREQA KEACKAAAEQ AISVRQQVVL ENAAKKRERA TSDPRTTEQK  60
   61 QEKKRLKISK KPKDPEPPEK EFTPYDYSQS DFKAFAGNSK SKVSSQFDPN KQTPSGKKCI 120
  121 AAKKIKQSVG NKSMSFPTGK SDRGFRYNWP QR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle