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Protein Overview: PRDX6

General Information:
Name(s) found: PRDX6 [HGNC (HUGO)]
Description(s) found:
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  • gi|77744395|gb|ABB02185.1| peroxiredoxin 6 [Homo sapiens] [NCBI NR]
  • gi|56204402|emb|CAI20936.1| peroxiredoxin 6 [Homo sapiens] [NCBI NR]
  • gi|4758638|ref|NP_004896.1| peroxiredoxin 6 [Homo sapiens] [NCBI NR]
  • gi|31657160|gb|AAH53550.1| Peroxiredoxin 6 [Homo sapiens] [NCBI NR]
  • gi|285949|dbj|BAA03496.1| KIAA0106 [Homo sapiens] [NCBI NR]
  • gi|23274223|gb|AAH35857.1| Peroxiredoxin 6 [Homo sapiens] [NCBI NR]
  • gi|1718024|sp|P30041.3|PRDX6_HUMAN RecName: Full=Peroxiredoxin-6; AltName: Full=Antioxidant protein 2; AltName: Full=1-Cys peroxiredoxin; Short=1-Cys PRX; AltName: Full=Acidic calcium-independent phospholipase A2; Short=aiPLA2; AltName: Full=Non-selenium [NCBI NR]
  • gi|158259727|dbj|BAF82041.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|119611351|gb|EAW90945.1| peroxiredoxin 6, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119611350|gb|EAW90944.1| peroxiredoxin 6, isoform CRA_a [Homo sapiens] [NCBI NR]
  • peroxiredoxin 6 [HGNC (HUGO)]
  • Peroxiredoxin-6 OS=Homo sapiens GN=PRDX6 PE=1 SV=3 [Swiss-Prot]
  • peroxiredoxin 6; antioxidant protein 2; non-selenium glutathione peroxidase; acidic calcium-independent phospholipase A2; 1-Cys peroxiredoxin [HMR_022704.fasta]
  • peroxiredoxin 6 [Homo sapiens]gi|31657160|gb|AAH53550.1| Peroxiredoxin 6 [Homo sapiens]gi|23274223|gb|AAH35857.1| Peroxiredoxin 6 [Homo sapiens]gi|285949|dbj|BAA03496.1| KIAA0106 [Homo sapiens]gi|1718024|sp|P30041|PDX6_HUMAN Peroxiredoxin 6 (Antioxida [nrdb_11152004_Chlamydomonas]
  • Peroxiredoxin 6 (Antioxidant protein 2) (1-Cys peroxiredoxin) (1-Cys PRX) (Acidic calcium-independent phospholipase A2) (aiPLA2) (Non-selenium glutathione peroxidase) (NSGPx) (24 kDa protein) (Liver 2D page spot 40) (Red blood cells page spot 12) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • (NM_004905) anti-oxidant protein 2 (non-selenium glutathione peroxidase, aci [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • peroxiredoxin 6 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Peroxiredoxin 6 [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • peroxiredoxin 6; antioxidant protein 2; non-selenium glutathione peroxidase; acidic calcium-independent phospholipase A2; 1-Cys peroxiredoxin [Homo sapiens] [HumanGallus06162005.fasta]
  • Peroxiredoxin-6 (Antioxidant protein 2) (1-Cys peroxiredoxin) (1-Cys PRX) (Acidic calcium-independent phospholipase A2) (aiPLA2) (Non-selenium glutathione peroxidase) (NSGPx) (24 kDa protein) (Liver 2D page spot 40) (Red blood cells page spot 12) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • peroxiredoxin 6, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Peroxiredoxin 6 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • KIAA0106 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 PEROXIREDOXIN 6 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PRDX6 Peroxiredoxin-6 [human-ipi-250309-contam.fasta]
  • IPI:IPI00220301.5|SWISS-PROT:P30041|TREMBL:A4UCS6;A8JZY7|ENSEMBL:ENSP00000342026|REFSEQ:NP_004896|H-INV:HIT000283339|VEGA:OTTHUMP00000032693 Tax_Id=9606 Gene_Symbol=PRDX6 Peroxiredoxin-6 [ipi.HUMAN.fasta.20090807]
  • Tax_Id=9606 Peroxiredoxin-6 [IPI_human_3.26.fasta]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=PRDX6 Peroxiredoxin-6 ENSG00000117592 IPI00220301 [drosphohumanreversed.fasta]
  • peroxiredoxin-6 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P30041;A8JZY7;P32077;Q5TAH4;Q5ZEZ8; RecName: Full=Peroxiredoxin-6; AltName: Full=Antioxidant protein 2; AltName: Full=1-Cys peroxiredoxin; AltName: Full=Acidic calcium-independent phospholipase A2; AltName: Full=Non-selenium glutathione peroxidase; AltName: Full=24 kDa protein; AltName: Full=Liver 2D page spot 40; AltName: Full=Red blood cells page spot 12; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Peroxiredoxin-6 OS=Homo sapiens GN=PRDX6 [011711_HMR.fasta]
  • IPI:IPI00220301.5|SWISS-PROT:P30041|TREMBL:A4UCS6|ENSEMBL:ENSP00000342026|REFSEQ:NP_004896|H-INV:HIT000283339|VEGA:OTTHUMP00000032693 Tax_Id=9606 Gene_Symbol=PRDX6 Peroxiredoxin-6 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=PRDX6 Synonyms=1-Cys|AOP2|KIAA0106|MGC46173|NSGPx|PRX|aiPLA2|p29 peroxiredoxin-6 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Peroxiredoxin-6 GN=PRDX6 [Doctor+uniprot-HUMAN-120911.fasta]
  • Epididymis secretory sperm binding protein Li 128m OS=Homo sapiens GN=HEL-S-128m PE=2 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 224 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGGLLLGDV APNFEANTTV GRIRFHDFLG DSWGILFSHP RDFTPVCTTE LGRAAKLAPE  60
   61 FAKRNVKLIA LSIDSVEDHL AWSKDINAYN CEEPTEKLPF PIIDDRNREL AILLGMLDPA 120
  121 EKDEKGMPVT ARVVFVFGPD KKLKLSILYP ATTGRNFDEI LRVVISLQLT AEKRVATPVD 180
  181 WKDGDSVMVL PTIPEEEAKK LFPKGVFTKE LPSGKKYLRY TPQP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..224] PSI-BLAST 61.69897 HorF6 peroxidase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • alkyl hydroperoxide reductase activity
    		•  4.29610283853788 bayes_pls_golite062009
  • antioxidant activity
    		•  3.8464796631544 bayes_pls_golite062009
  • peroxidase activity
    		•  3.43831566988273 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.43831566988273 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.56524997297011 bayes_pls_golite062009
  • selenium binding
    		•  2.35334277406288 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.30799114442278 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  2.23310780102446 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  1.47769936616412 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • transferase activity
    		•  1.26687471229876 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • protein binding
    		•  1.18479617596618 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11518182894524 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11518182894524 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • peptide binding
    		•  0.374493676068876 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  0.23291471505999 bayes_pls_golite062009
  • copper ion binding
    		•  0.178842772364502 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  0.16328723676608 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  0.0434052164026002 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle