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Protein Overview: NARFL

General Information:
Name(s) found: NARFL [HGNC (HUGO)]
Description(s) found:
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  • gi|74733617|sp|Q9H6Q4.1|NARFL_HUMAN RecName: Full=Nuclear prelamin A recognition factor-like protein; AltName: Full=Protein related to Narf; AltName: Full=Iron-only hydrogenase-like protein 1; Short=IOP1 [NCBI NR]
  • gi|22654872|gb|AAM98737.1| protein related to Narf [Homo sapiens] [NCBI NR]
  • gi|20988037|gb|AAH30248.1| Nuclear prelamin A recognition factor-like [Homo sapiens] [NCBI NR]
  • gi|123241839|emb|CAM26480.1| nuclear prelamin A recognition factor-like [Homo sapiens] [NCBI NR]
  • gi|11968051|ref|NP_071938.1| nuclear prelamin A recognition factor-like [Homo sapiens] [NCBI NR]
  • gi|119606128|gb|EAW85722.1| nuclear prelamin A recognition factor-like, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|10438222|dbj|BAB15199.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • nuclear prelamin A recognition factor-like [HGNC (HUGO)]
  • Cytosolic Fe-S cluster assembly factor NARFL OS=Homo sapiens GN=NARFL PE=1 SV=1 [Swiss-Prot]
  • Hypothetical protein FLJ21988 [hmr_yeast5_DM3-1_pombe.fasta]
  • nuclear prelamin A recognition factor-like; protein related to Narf [HMR_022704.fasta]
  • nuclear prelamin A recognition factor-like [Homo sapiens]gi|22654872|gb|AAM98737.1| protein related to Narf [Homo sapiens]gi|20988037|gb|AAH30248.1| Nuclear prelamin A recognition factor-like [Homo sapiens]gi|10438222|dbj|BAB15199.1| unnamed protein pr [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 Hypothetical protein FLJ21988 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_022493) hypothetical protein FLJ21988 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • nuclear prelamin A recognition factor-like [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • nuclear prelamin A recognition factor-like; protein related to Narf [Homo sapiens] [HumanGallus06162005.fasta]
  • Nuclear prelamin A recognition factor-like protein (Protein related to Narf) (Iron-only hydrogenase-like protein 1) (IOP1) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • nuclear prelamin A recognition factor-like, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Nuclear prelamin A recognition factor-like [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • protein related to Narf [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 CDNA: FLJ21988 fis, clone HEP06320 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 HYPOTHETICAL PROTEIN FLJ21988 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Nuclear prelamin A recognition factor-like protein; AltName: Full=Protein related to Narf; AltName: Full=Iron-only hydrogenase-like protein 1; Short=IOP1 [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=NARFL Isoform 1 of Nuclear prelamin A recognition factor-like protein [human-ipi-250309-contam.fasta]
  • IPI:IPI00008348.3|SWISS-PROT:Q9H6Q4-1|TREMBL:B3KPK9;B4DVC7|ENSEMBL:ENSP00000251588|REFSEQ:NP_071938|H-INV:HIT000008915|VEGA:OTTHUMP00000081267;OTTHUMP00000151179 Tax_Id=9606 Gene_Symbol=NARFL Isoform 1 of Nuclear prelamin A recognition factor-like protein [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=NARFL Isoform 1 of Cytosolic Fe-S cluster assembly factor NARFL [EBI-IPI_Human_3.71_03-24-2010_reversed.fasta]
  • Q9H6Q4;A1L385;B3KTJ3;Q53GC6;Q96S10;Q9H6J8; RecName: Full=Cytosolic Fe-S cluster assembly factor NARFL; AltName: Full=Nuclear prelamin A recognition factor-like protein; AltName: Full=Protein related to Narf; AltName: Full=Iron-only hydrogenase-like protein 1; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Cytosolic Fe-S cluster assembly factor NARFL OS=Homo sapiens GN=NARFL [011711_HMR.fasta]
  • IPI:IPI00008348.3|SWISS-PROT:Q9H6Q4-1|TREMBL:B3KPK9;B4DVC7|ENSEMBL:ENSP00000251588|REFSEQ:NP_071938|H-INV:HIT000008915|VEGA:OTTHUMP00000081267;OTTHUMP00000151179 Tax_Id=9606 Gene_Symbol=NARFL Isoform 1 of Cytosolic Fe-S cluster assembly factor NARFL [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=NARFL Synonyms=FLJ21988|HPRN|IOP1|LET1L|PRN cytosolic Fe-S cluster assembly factor NARFL [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00008348.3|SWISS-PROT:Q9H6Q4-1|TREMBL:B3KPK9;B4DVC7|ENSEMBL:ENSP00000251588|REFSEQ:NP_071938|H-INV:HIT000008915|VEGA:OTTHUMP00000151179 Tax_Id=9606 Gene_Symbol=NARFL Isoform 1 of Cytosolic Fe-S cluster assembly factor NARFL [ipi.HUMAN.20110912.fasta]
  • Cytosolic Fe-S cluster assembly factor NARFL GN=NARFL [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 476 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASPFSGALQ LTDLDDFIGP SQECIKPVKV EKRAGSGVAK IRIEDDGSYF QINQDGGTRR  60
   61 LEKAKVSLND CLACSGCITS AETVLITQQS HEELKKVLDA NKMAAPSQQR LVVVSVSPQS 120
  121 RASLAARFQL NPTDTARKLT SFFKKIGVHF VFDTAFSRHF SLLESQREFV RRFRGQADCR 180
  181 QALPLLASAC PGWICYAEKT HGSFILPHIS TARSPQQVMG SLVKDFFAQQ QHLTPDKIYH 240
  241 VTVMPCYDKK LEASRPDFFN QEHQTRDVDC VLTTGEVFRL LEEEGVSLPD LEPAPLDSLC 300
  301 SGASAEEPTS HRGGGSGGYL EHVFRHAARE LFGIHVAEVT YKPLRNKDFQ EVTLEKEGQV 360
  361 LLHFAMAYGF RNIQNLVQRL KRGRCPYHYV EVMACPSGCL NGGGQLQAPD RPSRELLQHV 420
  421 ERLYGMVRAE APEDAPGVQE LYTHWLQGTD SECAGRLLHT QYHAVEKAST GLGIRW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..476] PSI-BLAST 136.0 Fe-only hydrogenase, catalytic domain; Fe-only hydrogenase, N-terminal domain; Fe-only hydrogenase, second domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.47874003627413 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  1.31458462821219 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  1.18054918348653 bayes_pls_golite062009
  • metal cluster binding
    		•  1.18054918348653 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  1.10428419414285 bayes_pls_golite062009
  • lamin binding
    		•  0.863386378061341 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  0.778342926116907 bayes_pls_golite062009
  • catalytic activity
    		•  0.488483980994331 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  0.312816353615077 bayes_pls_golite062009
  • ferredoxin hydrogenase activity
    		•  0.278768281741128 bayes_pls_golite062009
  • oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
    		•  0.278768281741128 bayes_pls_golite062009
  • protein binding
    		•  0.221871950373022 bayes_pls_golite062009
  • electron carrier activity
    		•  0.0554226204149908 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle