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View Structure Prediction Details

Protein: NARFL
Organism: Homo sapiens
Length: 476 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NARFL.

Description E-value Query
Range		 Subject
Range
NARFL_RAT - Cytosolic Fe-S cluster assembly factor NARFL OS=Rattus norvegicus GN=Narfl PE=2 SV=1
 0.0 [1..476] [1..476]
NARFL_PONAB - Cytosolic Fe-S cluster assembly factor NARFL OS=Pongo abelii GN=NARFL PE=2 SV=1
NARFL_PONPY - Nuclear prelamin A recognition factor-like protein - Pongo pygmaeus (Orangutan)
 0.0 [1..476] [1..476]
gi|62897571 - gi|62897571|dbj|BAD96725.1| nuclear prelamin A recognition factor-like variant [Homo sapiens]
 0.0 [1..476] [1..476]
NARFL_BOVIN - Cytosolic Fe-S cluster assembly factor NARFL OS=Bos taurus GN=NARFL PE=2 SV=2
 0.0 [1..476] [1..476]
gi|114660220 - gi|114660220|ref|XP_510719.2| PREDICTED: nuclear prelamin A recognition factor-like isoform 7 [Pan t...
 0.0 [1..476] [1..476]
NARFL_MOUSE - Cytosolic Fe-S cluster assembly factor NARFL OS=Mus musculus GN=Narfl PE=1 SV=2
 0.0 [1..476] [1..476]

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Predicted Domain #1
Region A:
Residues: [1-476] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASPFSGALQ LTDLDDFIGP SQECIKPVKV EKRAGSGVAK IRIEDDGSYF QINQDGGTRR  60
   61 LEKAKVSLND CLACSGCITS AETVLITQQS HEELKKVLDA NKMAAPSQQR LVVVSVSPQS 120
  121 RASLAARFQL NPTDTARKLT SFFKKIGVHF VFDTAFSRHF SLLESQREFV RRFRGQADCR 180
  181 QALPLLASAC PGWICYAEKT HGSFILPHIS TARSPQQVMG SLVKDFFAQQ QHLTPDKIYH 240
  241 VTVMPCYDKK LEASRPDFFN QEHQTRDVDC VLTTGEVFRL LEEEGVSLPD LEPAPLDSLC 300
  301 SGASAEEPTS HRGGGSGGYL EHVFRHAARE LFGIHVAEVT YKPLRNKDFQ EVTLEKEGQV 360
  361 LLHFAMAYGF RNIQNLVQRL KRGRCPYHYV EVMACPSGCL NGGGQLQAPD RPSRELLQHV 420
  421 ERLYGMVRAE APEDAPGVQE LYTHWLQGTD SECAGRLLHT QYHAVEKAST GLGIRW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 136.0
Match: 1c4aA
Description: Fe-only hydrogenase, catalytic domain; Fe-only hydrogenase, N-terminal domain; Fe-only hydrogenase, second domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.47874003627413 bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity 1.31458462821219 bayes_pls_golite062009
iron-sulfur cluster binding 1.18054918348653 bayes_pls_golite062009
metal cluster binding 1.18054918348653 bayes_pls_golite062009
NADH dehydrogenase activity 1.10428419414285 bayes_pls_golite062009
lamin binding 0.863386378061341 bayes_pls_golite062009
NADH dehydrogenase (quinone) activity 0.778342926116907 bayes_pls_golite062009
catalytic activity 0.488483980994331 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 0.312816353615077 bayes_pls_golite062009
ferredoxin hydrogenase activity 0.278768281741128 bayes_pls_golite062009
oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor 0.278768281741128 bayes_pls_golite062009
protein binding 0.221871950373022 bayes_pls_golite062009
electron carrier activity 0.0554226204149908 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle