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Protein Overview: CDK12

General Information:
Name(s) found: CDK12 [HGNC (HUGO)]
Description(s) found:
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  • gi|7706549|ref|NP_057591.1| Cdc2-related kinase, arginine/serine-rich [Homo sapiens] [NCBI NR]
  • gi|7107392|gb|AAF36401.1|AF227198_1 CrkRS [Homo sapiens] [NCBI NR]
  • gi|12643825|sp|Q9NYV4.1|CD2L7_HUMAN RecName: Full=Cell division cycle 2-related protein kinase 7; Short=CDC2-related protein kinase 7; AltName: Full=Cdc2-related kinase, arginine/serine-rich; Short=CrkRS [NCBI NR]
  • Cdc2-related kinase, arginine/serine-rich [HGNC (HUGO)]
  • cyclin-dependent kinase 12 [HGNC (HUGO)]
  • (Q9NYV4) Cell division cycle 2-related protein kinase 7 (EC 2.7.1.37) (CDC2-related protein kinase 7) (CrkRS) [Swiss-Prot]
  • Cell division protein kinase 12 OS=Homo sapiens GN=CDK12 PE=1 SV=1 [Swiss-Prot]
  • Cell division cycle 2-related protein kinase 7 OS=Homo sapiens GN=CRKRS PE=1 SV=1 [Swiss-Prot]
  • Cell division cycle 2-related protein kinase 7 [hmr_yeast5_DM3-1_pombe.fasta]
  • CDC2-related protein kinase 7 [HMR_022704.fasta]
  • CDC2-related protein kinase 7 [Homo sapiens]gi|12643825|sp|Q9NYV4|CRK7_HUMAN Cell division cycle 2-related protein kinase 7 (CDC2-related protein kinase 7) (CrkRS)gi|7107392|gb|AAF36401.1| CrkRS [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Cell division cycle 2-related protein kinase 7 (CDC2-related protein kinase 7) (CrkRS) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Cell division cycle 2-related protein kinase 7 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_016507) CDC2-related protein kinase 7 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • CDC2-related protein kinase 7 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Cell division cycle 2-related protein kinase 7 (CDC2-related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • CrkRS [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 CELL DIVISION CYCLE 2-RELATED PROTEIN KINASE 7 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=CRKRS Isoform 1 of Cell division cycle 2-related protein kinase 7 [human-ipi-250309-contam.fasta]
  • IPI:IPI00021175.1|SWISS-PROT:Q9NYV4-1|ENSEMBL:ENSP00000398880|REFSEQ:NP_057591|H-INV:HIT000074461|VEGA:OTTHUMP00000164282;OTTHUMP00000181141 Tax_Id=9606 Gene_Symbol=CRKRS Isoform 1 of Cell division cycle 2-related protein kinase 7 [ipi.HUMAN.fasta.20090807]
  • Tax_Id=9606 Gene_Symbol=CRKRS Cell division cycle 2-related protein kinase 7 ENSG00000167258 IPI00021175 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=CRKRS Cell division cycle 2-related protein kinase 7 [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=CDK12 Isoform 1 of Cell division protein kinase 12 [EBI-IPI_Human_3.71_03-24-2010_reversed.fasta]
  • Q9NYV4;A7E2B2;O94978; RecName: Full=Cell division protein kinase 12; AltName: Full=Cell division cycle 2-related protein kinase 7; AltName: Full=Cdc2-related kinase, arginine/serine-rich; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • IPI:IPI00021175.1|SWISS-PROT:Q9NYV4-1|ENSEMBL:ENSP00000398880|REFSEQ:NP_057591|H-INV:HIT000074461|VEGA:OTTHUMP00000164282;OTTHUMP00000181141 Tax_Id=9606 Gene_Symbol=CDK12 Isoform 1 of Cell division protein kinase 12 [ipi.HUMAN.fasta.20100406]
    • Organism: Homo sapiens
    Length: 1490 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNSERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLVS KHKRHKSKHS KDMGLVTPEA  60
   61 ASLGTVIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR GSDRSDRLHK HRHHQHRRSR 120
  121 DLLKAKQTEK EKSQEVSSKS GSMKDRISGS SKRSNEETDD YGKAQVAKSS SKESRSSKLH 180
  181 KEKTRKEREL KSGHKDRSKS HRKRETPKSY KTVDSPKRRS RSPHRKWSDS SKQDDSPSGA 240
  241 SYGQDYDLSP SRSHTSSNYD SYKKSPGSTS RRQSVSPPYK EPSAYQSSTR SPSPYSRRQR 300
  301 SVSPYSRRRS SSYERSGSYS GRSPSPYGRR RSSSPFLSKR SLSRSPLPSR KSMKSRSRSP 360
  361 AYSRHSSSHS KKKRSSSRSR HSSISPVRLP LNSSLGAELS RKKKERAAAA AAAKMDGKES 420
  421 KGSPVFLPRK ENSSVEAKDS GLESKKLPRS VKLEKSAPDT ELVNVTHLNT EVKNSSDTGK 480
  481 VKLDENSEKH LVKDLKAQGT RDSKPIALKE EIVTPKETET SEKETPPPLP TIASPPPPLP 540
  541 TTTPPPQTPP LPPLPPIPAL PQQPPLPPSQ PAFSQVPASS TSTLPPSTHS KTSAVSSQAN 600
  601 SQPPVQVSVK TQVSVTAAIP HLKTSTLPPL PLPPLLPGGD DMDSPKETLP SKPVKKEKEQ 660
  661 RTRHLLTDLP LPPELPGGDL SPPDSPEPKA ITPPQQPYKK RPKICCPRYG ERRQTESDWG 720
  721 KRCVDKFDII GIIGEGTYGQ VYKARDKDTG ELVALKKVRL DNEKEGFPIT AIREIKILRQ 780
  781 LIHRSVVNMK EIVTDKQDAL DFKKDKGAFY LVFEYMDHDL MGLLESGLVH FSEDHIKSFM 840
  841 KQLMEGLEYC HKKNFLHRDI KCSNILLNNS GQIKLADFGL ARLYNSEESR PYTNKVITLW 900
  901 YRPPELLLGE ERYTPAIDVW SCGCILGELF TKKPIFQANL ELAQLELISR LCGSPCPAVW 960
  961 PDVIKLPYFN TMKPKKQYRR RLREEFSFIP SAALDLLDHM LTLDPSKRCT AEQTLQSDFL1020
 1021 KDVELSKMAP PDLPHWQDCH ELWSKKRRRQ RQSGVVVEEP PPSKTSRKET TSGTSTEPVK1080
 1081 NSSPAPPQPA PGKVESGAGD AIGLADITQQ LNQSELAVLL NLLQSQTDLS IPQMAQLLNI1140
 1141 HSNPEMQQQL EALNQSISAL TEATSQQQDS ETMAPEESLK EAPSAPVILP SAEQMTLEAS1200
 1201 STPADMQNIL AVLLSQLMKT QEPAGSLEEN NSDKNSGPQG PRRTPTMPQE EAAACPPHIL1260
 1261 PPEKRPPEPP GPPPPPPPPP LVEGDLSSAP QELNPAVTAA LLQLLSQPEA EPPGHLPHEH1320
 1321 QALRPMEYST RPRPNRTYGN TDGPETGFSA IDTDERNSGP ALTESLVQTL VKNRTFSGSL1380
 1381 SHLGESSSYQ GTGSVQFPGD QDLRFARVPL ALHPVVGQPF LKAEGSSNSV VHAETKLQNY1440
 1441 GELGPGTTGA SSSGAGLHWG GPTQSSAYGK LYRGPTRVPP RGGRGRGVPY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..436] FFAS03 1.98 30S subunit
    2 View Details [437..651] deduced N/A No confident structure predictions are available.
    3 View Details [652..721] PSI-BLAST 25.154902 No description for 2pziA was found.
    4 View Details [722..1071] PSI-BLAST 87.39794 Structure of CDK2/Cyclin A with PNU-292137
    5 View Details [1072..1373] deduced N/A No confident structure predictions are available.
    6 View Details [1374..1490] MSA 1.168995 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle