| Protein: | CDK12 |
| Organism: | Homo sapiens |
| Length: | 1490 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDK12.
| Description | E-value | Query Range |
Subject Range |
|
|
594.0 | [0..1] | [1490..55] |
|
|
587.0 | [0..1] | [1490..1] |
|
|
579.0 | [0..1] | [1490..1] |
|
|
577.0 | [0..1] | [1490..1] |
|
|
506.0 | [0..685] | [1490..4] |
|
Region A: Residues: [1-436] |
1 11 21 31 41 51
| | | | | |
1 MPNSERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLVS KHKRHKSKHS KDMGLVTPEA 60
61 ASLGTVIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR GSDRSDRLHK HRHHQHRRSR 120
121 DLLKAKQTEK EKSQEVSSKS GSMKDRISGS SKRSNEETDD YGKAQVAKSS SKESRSSKLH 180
181 KEKTRKEREL KSGHKDRSKS HRKRETPKSY KTVDSPKRRS RSPHRKWSDS SKQDDSPSGA 240
241 SYGQDYDLSP SRSHTSSNYD SYKKSPGSTS RRQSVSPPYK EPSAYQSSTR SPSPYSRRQR 300
301 SVSPYSRRRS SSYERSGSYS GRSPSPYGRR RSSSPFLSKR SLSRSPLPSR KSMKSRSRSP 360
361 AYSRHSSSHS KKKRSSSRSR HSSISPVRLP LNSSLGAELS RKKKERAAAA AAAKMDGKES 420
421 KGSPVFLPRK ENSSVE
|
| Detection Method: |  |
| Confidence: | 1.98 |
| Match: | 1dv4A |
| Description: | 30S subunit |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [437-651] |
1 11 21 31 41 51
| | | | | |
1 AKDSGLESKK LPRSVKLEKS APDTELVNVT HLNTEVKNSS DTGKVKLDEN SEKHLVKDLK 60
61 AQGTRDSKPI ALKEEIVTPK ETETSEKETP PPLPTIASPP PPLPTTTPPP QTPPLPPLPP 120
121 IPALPQQPPL PPSQPAFSQV PASSTSTLPP STHSKTSAVS SQANSQPPVQ VSVKTQVSVT 180
181 AAIPHLKTST LPPLPLPPLL PGGDDMDSPK ETLPS
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [652-721] |
1 11 21 31 41 51
| | | | | |
1 KPVKKEKEQR TRHLLTDLPL PPELPGGDLS PPDSPEPKAI TPPQQPYKKR PKICCPRYGE 60
61 RRQTESDWGK
|
| Detection Method: | |
| Confidence: | 25.154902 |
| Match: | 2pziA |
| Description: | No description for 2pziA was found. |
|
Region A: Residues: [722-1071] |
1 11 21 31 41 51
| | | | | |
1 RCVDKFDIIG IIGEGTYGQV YKARDKDTGE LVALKKVRLD NEKEGFPITA IREIKILRQL 60
61 IHRSVVNMKE IVTDKQDALD FKKDKGAFYL VFEYMDHDLM GLLESGLVHF SEDHIKSFMK 120
121 QLMEGLEYCH KKNFLHRDIK CSNILLNNSG QIKLADFGLA RLYNSEESRP YTNKVITLWY 180
181 RPPELLLGEE RYTPAIDVWS CGCILGELFT KKPIFQANLE LAQLELISRL CGSPCPAVWP 240
241 DVIKLPYFNT MKPKKQYRRR LREEFSFIPS AALDLLDHML TLDPSKRCTA EQTLQSDFLK 300
301 DVELSKMAPP DLPHWQDCHE LWSKKRRRQR QSGVVVEEPP PSKTSRKETT
|
| Detection Method: | |
| Confidence: | 87.39794 |
| Match: | 1vywA |
| Description: | Structure of CDK2/Cyclin A with PNU-292137 |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [1072-1373] |
1 11 21 31 41 51
| | | | | |
1 SGTSTEPVKN SSPAPPQPAP GKVESGAGDA IGLADITQQL NQSELAVLLN LLQSQTDLSI 60
61 PQMAQLLNIH SNPEMQQQLE ALNQSISALT EATSQQQDSE TMAPEESLKE APSAPVILPS 120
121 AEQMTLEASS TPADMQNILA VLLSQLMKTQ EPAGSLEENN SDKNSGPQGP RRTPTMPQEE 180
181 AAACPPHILP PEKRPPEPPG PPPPPPPPPL VEGDLSSAPQ ELNPAVTAAL LQLLSQPEAE 240
241 PPGHLPHEHQ ALRPMEYSTR PRPNRTYGNT DGPETGFSAI DTDERNSGPA LTESLVQTLV 300
301 KN
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1374-1490] |
1 11 21 31 41 51
| | | | | |
1 RTFSGSLSHL GESSSYQGTG SVQFPGDQDL RFARVPLALH PVVGQPFLKA EGSSNSVVHA 60
61 ETKLQNYGEL GPGTTGASSS GAGLHWGGPT QSSAYGKLYR GPTRVPPRGG RGRGVPY
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
