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Protein Overview: OSBPL3

General Information:
Name(s) found: OSBPL3 [HGNC (HUGO)]
Description(s) found:
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  • gi|51094996|gb|EAL24240.1| oxysterol binding protein-like 3 [Homo sapiens] [NCBI NR]
  • gi|20531133|gb|AAM27386.1|AF491781_1 oxysterol binding protein-related protein 3 isoform 1a [Homo sapiens] [NCBI NR]
  • gi|20139176|sp|Q9H4L5.1|OSBL3_HUMAN RecName: Full=Oxysterol-binding protein-related protein 3; Short=OSBP-related protein 3; Short=ORP-3 [NCBI NR]
  • gi|17529987|gb|AAL40657.1|AF392444_1 oxysterol-binding protein-like protein OSBPL3 [Homo sapiens] [NCBI NR]
  • gi|17389382|gb|AAH17731.1| Oxysterol binding protein-like 3 [Homo sapiens] [NCBI NR]
  • gi|14149704|ref|NP_056365.1| oxysterol-binding protein-like protein 3 isoform a [Homo sapiens] [NCBI NR]
  • gi|119614224|gb|EAW93818.1| hCG38836, isoform CRA_d [Homo sapiens] [NCBI NR]
  • gi|10880973|gb|AAG23400.1| oxysterol binding protein-related protein 3 [Homo sapiens] [NCBI NR]
  • oxysterol binding protein-like 3 [HGNC (HUGO)]
  • Oxysterol-binding protein-related protein 3 OS=Homo sapiens GN=OSBPL3 PE=1 SV=1 [Swiss-Prot]
  • (Q9H4L5) Oxysterol binding protein-related protein 3 (OSBP-related protein 3) (ORP-3) [Swiss-Prot]
  • Oxysterol binding protein-related protein 3 [hmr_yeast5_DM3-1_pombe.fasta]
  • oxysterol-binding protein-like protein 3 isoform a; oxysterol-binding protein-related protein 3; oxysterol-binding protein 3; OSBP-related protein 3 [HMR_022704.fasta]
  • oxysterol binding protein-like 3 [Homo sapiens]gi|14149704|ref|NP_056365.1| oxysterol-binding protein-like protein 3 isoform a [Homo sapiens]gi|17389382|gb|AAH17731.1| Oxysterol-binding protein-like protein 3, isoform a [Homo sapiens]gi|20531133|gb|AAM [nrdb_11152004_Chlamydomonas]
  • Oxysterol binding protein-related protein 3 (OSBP-related protein 3) (ORP-3) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1a of Oxysterol-binding protein-related protein 3 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_015550) oxysterol-binding protein-like protein 3, isoform a; oxysterol-binding protein-related protein 3; oxysterol-binding protein 3; OSBP-related protein 3 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • oxysterol-binding protein-like protein 3 isoform a [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1a of Oxysterol binding protein-related protein 3 [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta]
  • oxysterol-binding protein-like protein 3 isoform a; oxysterol-binding protein-related protein 3; oxysterol-binding protein 3; OSBP-related protein 3 [Homo sapiens] [HumanGallus06162005.fasta]
  • Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • hCG38836, isoform CRA_d [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Oxysterol binding protein-like 3 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • oxysterol binding protein-related protein 3 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • oxysterol binding protein-like 3 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • oxysterol binding protein-related protein 3 isoform 1a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • oxysterol-binding protein-like protein OSBPL3 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1a of Oxysterol-binding protein-related protein 3 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF OXYSTEROL BINDING PROTEIN-RELATED PROTEIN 3 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=OSBPL3 Isoform 1a of Oxysterol-binding protein-related protein 3 [human-ipi-250309-contam.fasta]
  • IPI:IPI00023555.1|SWISS-PROT:Q9H4L5-1|TREMBL:A4D167|ENSEMBL:ENSP00000315410|REFSEQ:NP_056365|H-INV:HIT000078849|VEGA:OTTHUMP00000024895;OTTHUMP00000122489 Tax_Id=9606 Gene_Symbol=OSBPL3 Isoform 1a of Oxysterol-binding protein-related protein 3 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=OSBPL3 Isoform 1a of Oxysterol-binding protein-related protein 3 ENSG00000070882 IPI00023555 IPI00162669 IPI00167053 IPI00162670 IPI00169299 IPI00169296 IPI00375694 IPI00375695 [drosphohumanreversed.fasta]
  • Q9H4L5;A4D167;A4D168;A4D169;A4D170;A4D171;A4D172;B8ZZ79;B8ZZP0;O14591;O43357;O43358;Q8N702;Q8N703;Q8N704;Q8NFH0;Q8NFH1;Q8NI12;Q8NI13;Q9BZF4;Q9UED6; RecName: Full=Oxysterol-binding protein-related protein 3; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1a of Oxysterol-binding protein-related protein 3 OS=Homo sapiens GN=OSBPL3 [011711_HMR.fasta]
  • IPI:IPI00023555.1|SWISS-PROT:Q9H4L5-1|ENSEMBL:ENSP00000315410|REFSEQ:NP_056365|H-INV:HIT000078849|VEGA:OTTHUMP00000024895;OTTHUMP00000122489 Tax_Id=9606 Gene_Symbol=OSBPL3 Isoform 1a of Oxysterol-binding protein-related protein 3 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=OSBPL3 Synonyms=DKFZp667P1518|KIAA0704|MGC21526|ORP-3|ORP3|OSBP3 oxysterol-binding protein-related protein 3 isoform a [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00023555.1|SWISS-PROT:Q9H4L5-1|ENSEMBL:ENSP00000315410|REFSEQ:NP_056365|H-INV:HIT000078849|VEGA:OTTHUMP00000122489 Tax_Id=9606 Gene_Symbol=OSBPL3 Isoform 1a of Oxysterol-binding protein-related protein 3 [ipi.HUMAN.20110912.fasta]
  • Oxysterol-binding protein-related protein 3 GN=OSBPL3 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 887 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE PPVQKGFLLK  60
   61 KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID VGLSVMSVKK SSKCIDLDTE 120
  121 EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN EIAMFPHEVN HFFSGSTITD SSSGVFDSIS 180
  181 SRKRSSISKQ NLFQTGSNVS FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL 240
  241 QSMDVLHRTY SAPAINAIQG GSFESPKKEK RSHRRWRSRA IGKDAKGTLQ VPKPFSGPVR 300
  301 LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLCHIA HKVYFTLRSA FNIMSAEREK 360
  361 LKQLMEQDAS SSPSAQVIGL KNALSSALAQ NTDLKERLRR IHAESLLLDS PAVAKSGDNL 420
  421 AEENSRDENR ALVHQLSNES RLSITDSLSE FFDAQEVLLS PSSSENEISD DDSYVSDISD 480
  481 NLSLDNLSND LDNERQTLGP VLDSGREAKS RRRTCLPAPC PSSSNISLWN ILRNNIGKDL 540
  541 SKVAMPVELN EPLNTLQRLC EELEYSELLD KAAQIPSPLE RMVYVAAFAI SAYASSYYRA 600
  601 GSKPFNPVLG ETYECIREDK GFQFFSEQVS HHPPISACHA ESRNFVFWQD VRWKNKFWGK 660
  661 SMEIVPIGTT HVTLPVFGDH FEWNKVTSCI HNILSGQRWI EHYGEIVIKN LHDDSCYCKV 720
  721 NFIKAKYWST NAHEIEGTVF DRSGKAVHRL FGKWHESIYC GGGSSSACVW RANPMPKGYE 780
  781 QYYSFTQFAL ELNEMDPSSK SLLPPTDTRF RPDQRFLEEG NLEEAEIQKQ RIEQLQRERR 840
  841 RVLEENHVEH QPRFFRKSDD DSWVSNGTYL ELRKDLGFSK LDHPVLW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..162] PSI-BLAST 14.69897 Crystal Structure of a N-terminal Fragment of SKAP-Hom Containing Both the Helical Dimerization Domain and the PH Domain
    2 View Details [163..319] deduced N/A No confident structure predictions are available.
    3 View Details [320..523] deduced N/A No confident structure predictions are available.
    4 View Details [524..887] PSI-BLAST 80.30103 Structure of yeast oxysterol binding protein Osh4 in complex with 7-hydroxycholesterol

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.42470476396787 bayes_pls_golite062009
  • protein binding
    		•  2.1446140694885 bayes_pls_golite062009
  • receptor binding
    		•  0.3173431866346 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • sterol binding
    		•  3.12877992228795 bayes_pls_golite062009
  • steroid binding
    		•  2.54679035876403 bayes_pls_golite062009
  • binding
    		•  1.67154210149282 bayes_pls_golite062009
  • lipid binding
    		•  1.46539100663772 bayes_pls_golite062009
  • oxysterol binding
    		•  1.1738554488982 bayes_pls_golite062009
  • phospholipid binding
    		•  0.0867097353003303 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle