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View Structure Prediction Details

Protein: OSBPL3
Organism: Homo sapiens
Length: 887 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OSBPL3.

Description E-value Query
Range
Subject
Range
gi|27529722 - gi|27529722|dbj|BAA31679.2| KIAA0704 protein [Homo sapiens]
0.0 [1..887] [33..919]
gi|114612420, gi... - gi|114612426|ref|XP_001160331.1| PREDICTED: oxysterol-binding protein-like protein 3 isoform 9 [Pan ...
0.0 [2..887] [1..886]
gi|73976054 - gi|73976054|ref|XP_539480.2| PREDICTED: similar to oxysterol-binding protein-like protein 3 isoform ...
0.0 [1..887] [1..887]
gi|109473484, gi... - gi|109473484|ref|XP_001055606.1| PREDICTED: similar to Oxysterol-binding protein-related protein 3 (...
0.0 [2..887] [1..886]

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Predicted Domain #1
Region A:
Residues: [1-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE PPVQKGFLLK  60
   61 KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID VGLSVMSVKK SSKCIDLDTE 120
  121 EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN EIAMFPHEVN HF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 1u5eA
Description: Crystal Structure of a N-terminal Fragment of SKAP-Hom Containing Both the Helical Dimerization Domain and the PH Domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.42470476396787 bayes_pls_golite062009
protein binding 2.1446140694885 bayes_pls_golite062009
receptor binding 0.3173431866346 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [163-319]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSGSTITDSS SGVFDSISSR KRSSISKQNL FQTGSNVSFS CGGETRVPLW LQSSEDMEKC  60
   61 SKDLAHCHAY LVEMSQLLQS MDVLHRTYSA PAINAIQGGS FESPKKEKRS HRRWRSRAIG 120
  121 KDAKGTLQVP KPFSGPVRLH SSNPNLSTLD FGEEKNY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [320-523]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDGSETSSEF SKMQEDLCHI AHKVYFTLRS AFNIMSAERE KLKQLMEQDA SSSPSAQVIG  60
   61 LKNALSSALA QNTDLKERLR RIHAESLLLD SPAVAKSGDN LAEENSRDEN RALVHQLSNE 120
  121 SRLSITDSLS EFFDAQEVLL SPSSSENEIS DDDSYVSDIS DNLSLDNLSN DLDNERQTLG 180
  181 PVLDSGREAK SRRRTCLPAP CPSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [524-887]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNISLWNILR NNIGKDLSKV AMPVELNEPL NTLQRLCEEL EYSELLDKAA QIPSPLERMV  60
   61 YVAAFAISAY ASSYYRAGSK PFNPVLGETY ECIREDKGFQ FFSEQVSHHP PISACHAESR 120
  121 NFVFWQDVRW KNKFWGKSME IVPIGTTHVT LPVFGDHFEW NKVTSCIHNI LSGQRWIEHY 180
  181 GEIVIKNLHD DSCYCKVNFI KAKYWSTNAH EIEGTVFDRS GKAVHRLFGK WHESIYCGGG 240
  241 SSSACVWRAN PMPKGYEQYY SFTQFALELN EMDPSSKSLL PPTDTRFRPD QRFLEEGNLE 300
  301 EAEIQKQRIE QLQRERRRVL EENHVEHQPR FFRKSDDDSW VSNGTYLELR KDLGFSKLDH 360
  361 PVLW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.30103
Match: 1zhtA
Description: Structure of yeast oxysterol binding protein Osh4 in complex with 7-hydroxycholesterol
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
sterol binding 3.12877992228795 bayes_pls_golite062009
steroid binding 2.54679035876403 bayes_pls_golite062009
binding 1.67154210149282 bayes_pls_golite062009
lipid binding 1.46539100663772 bayes_pls_golite062009
oxysterol binding 1.1738554488982 bayes_pls_golite062009
phospholipid binding 0.0867097353003303 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle