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Protein Overview: DUS2L

General Information:
Name(s) found: DUS2L [HGNC (HUGO)]
Description(s) found:
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  • gi|8923374|ref|NP_060273.1| dihydrouridine synthase 2-like, SMM1 homolog [Homo sapiens] [NCBI NR]
  • gi|73620832|sp|Q9NX74.1|DUS2L_HUMAN RecName: Full=tRNA-dihydrouridine synthase 2-like; Short=hDUS2; AltName: Full=Up-regulated in lung cancer; AltName: Full=URLC8 [NCBI NR]
  • gi|71006842|dbj|BAE07219.1| up-regulated in lung cancer 8 [Homo sapiens] [NCBI NR]
  • gi|7020473|dbj|BAA91143.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|16306804|gb|AAH06527.1| Dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae) [Homo sapiens] [NCBI NR]
  • gi|158254588|dbj|BAF83267.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|119603615|gb|EAW83209.1| dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119603614|gb|EAW83208.1| dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119603613|gb|EAW83207.1| dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae), isoform CRA_a [Homo sapiens] [NCBI NR]
  • dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae) [HGNC (HUGO)]
  • tRNA-dihydrouridine(20) synthase [NAD(P)+]-like OS=Homo sapiens GN=DUS2 PE=1 SV=1 [Swiss-Prot]
  • Hypothetical protein FLJ20399 [hmr_yeast5_DM3-1_pombe.fasta]
  • hypothetical protein FLJ20399 [HMR_022704.fasta]
  • hypothetical protein FLJ20399 [Homo sapiens]gi|7020473|dbj|BAA91143.1| unnamed protein product [Homo sapiens]gi|16306804|gb|AAH06527.1| Hypothetical protein FLJ20399 [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • tRNA-dihydrouridine synthase 2-like [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 tRNA-dihydrouridine synthase 2-like [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_017803) hypothetical protein FLJ20399 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • dihydrouridine synthase 2-like, SMM1 homolog [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Hypothetical protein FLJ20399 [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • hypothetical protein FLJ20399 [Homo sapiens] [HumanGallus06162005.fasta]
  • tRNA-dihydrouridine synthase 2-like (hDUS2) (Up-regulated in lung cancer) (URLC8) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae), isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • up-regulated in lung cancer 8 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 HYPOTHETICAL PROTEIN FLJ20399 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=DUS2L tRNA-dihydrouridine synthase 2-like [human-ipi-250309-contam.fasta]
  • IPI:IPI00015804.1|SWISS-PROT:Q9NX74|TREMBL:A8K3G3|ENSEMBL:ENSP00000351769|REFSEQ:NP_060273|H-INV:HIT000290199|VEGA:OTTHUMP00000080570;OTTHUMP00000080571;OTTHUMP00000174842 Tax_Id=9606 Gene_Symbol=DUS2L tRNA-dihydrouridine synthase 2-like [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=DUS2L tRNA-dihydrouridine synthase 2-like ENSG00000167264 IPI00015804 [drosphohumanreversed.fasta]
  • tRNA-dihydrouridine synthase 2-like [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • tRNA-dihydrouridine synthase 2-like OS=Homo sapiens GN=DUS2L PE=1 SV=1 [UniProtHuman070710.fasta]
  • Q9NX74;A8K3G3;Q4H4D9; RecName: Full=tRNA-dihydrouridine synthase 2-like; AltName: Full=Up-regulated in lung cancer protein 8; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • tRNA-dihydrouridine synthase 2-like OS=Homo sapiens GN=DUS2L [011711_HMR.fasta]
  • IPI:IPI00015804.1|SWISS-PROT:Q9NX74|ENSEMBL:ENSP00000351769|REFSEQ:NP_060273|H-INV:HIT000290199|VEGA:OTTHUMP00000080570;OTTHUMP00000080571;OTTHUMP00000174842 Tax_Id=9606 Gene_Symbol=DUS2L tRNA-dihydrouridine synthase 2-like [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=DUS2L Synonyms=DUS2|FLJ20399|SMM1|URLC8 tRNA-dihydrouridine synthase 2-like [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • tRNA-dihydrouridine(20) synthase [NAD(P)+]-like OS=Homo sapiens GN=DUS2L PE=1 SV=1 [uniprot-human-120502.fasta]
  • IPI:IPI00015804.1|SWISS-PROT:Q9NX74|ENSEMBL:ENSP00000351769|REFSEQ:NP_060273|H-INV:HIT000290199|VEGA:OTTHUMP00000174842 Tax_Id=9606 Gene_Symbol=DUS2L tRNA-dihydrouridine synthase 2-like [ipi.HUMAN.20110912.fasta]
  • tRNA-dihydrouridine(20) synthase [NAD(P)+]-like GN=DUS2L [Doctor+uniprot-HUMAN-120911.fasta]
  • Dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae), isoform CRA_a OS=Homo sapiens GN=DUS2L PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 493 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MILNSLSLCY HNKLILAPMV RVGTLPMRLL ALDYGADIVY CEELIDLKMI QCKRVVNEVL  60
   61 STVDFVAPDD RVVFRTCERE QNRVVFQMGT SDAERALAVA RLVENDVAGI DVNMGCPKQY 120
  121 STKGGMGAAL LSDPDKIEKI LSTLVKGTRR PVTCKIRILP SLEDTLSLVK RIERTGIAAI 180
  181 AVHGRKREER PQHPVSCEVI KAIADTLSIP VIANGGSHDH IQQYSDIEDF RQATAASSVM 240
  241 VARAAMWNPS IFLKEGLRPL EEVMQKYIRY AVQYDNHYTN TKYCLCQMLR EQLESPQGRL 300
  301 LHAAQSSREI CEAFGLGAFY EETTQELDAQ QARLSAKTSE QTGEPAEDTS GVIKMAVKFD 360
  361 RRAYPAQITP KMCLLEWCRR EKLAQPVYET VQRPLDRLFS SIVTVAEQKY QSTLWDKSKK 420
  421 LAEQAAAIVC LRSQGLPEGR LGEESPSLHK RKREAPDQDP GGPRAQELAQ PGDLCKKPFV 480
  481 ALGSGEESPL EGW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..346] PSI-BLAST 40.221849 Crystal structure of a putative flavin oxidoreductase with flavin
    2 View Details [347..493] PSI-BLAST 27.09691 Solution structure of the dsRBD from hypothetical protein BAB26260

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.94749091175302 bayes_pls_golite062009
  • tRNA dihydrouridine synthase activity
    		•  1.94490879164338 bayes_pls_golite062009
    2
    Term Confidence Notes
  • RNA binding
    		•  2.539601915417 bayes_pls_golite062009
  • binding
    		•  1.80132856651319 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.57684875880134 bayes_pls_golite062009
  • double-stranded RNA binding
    		•  1.06206547102508 bayes_pls_golite062009
  • protein binding
    		•  0.927977287431555 bayes_pls_golite062009
  • DNA binding
    		•  0.0536460773631342 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle