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Protein Overview: RACGAP1

General Information:
Name(s) found: RACGAP1 [HGNC (HUGO)]
Description(s) found:
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  • gi|74762727|sp|Q9H0H5.1|RGAP1_HUMAN RecName: Full=Rac GTPase-activating protein 1; AltName: Full=Male germ cell RacGap; Short=MgcRacGAP [NCBI NR]
  • gi|49065556|emb|CAG38596.1| RACGAP1 [Homo sapiens] [NCBI NR]
  • gi|21595805|gb|AAH32754.1| RACGAP1 protein [Homo sapiens] [NCBI NR]
  • gi|21361397|ref|NP_037409.2| Rac GTPase activating protein 1 [Homo sapiens] [NCBI NR]
  • gi|186910302|ref|NP_001119576.1| Rac GTPase activating protein 1 [Homo sapiens] [NCBI NR]
  • gi|186910300|ref|NP_001119575.1| Rac GTPase activating protein 1 [Homo sapiens] [NCBI NR]
  • gi|12053101|emb|CAB66728.1| hypothetical protein [Homo sapiens] [NCBI NR]
  • gi|119578519|gb|EAW58115.1| Rac GTPase activating protein 1, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119578518|gb|EAW58114.1| Rac GTPase activating protein 1, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119578517|gb|EAW58113.1| Rac GTPase activating protein 1, isoform CRA_a [Homo sapiens] [NCBI NR]
  • Rac GTPase activating protein 1 [HGNC (HUGO)]
  • Rac GTPase-activating protein 1 OS=Homo sapiens GN=RACGAP1 PE=1 SV=1 [Swiss-Prot]
  • Hypothetical protein [hmr_yeast5_DM3-1_pombe.fasta]
  • Rac GTPase activating protein 1; GTPase activating protein [HMR_022704.fasta]
  • RACGAP1 protein [Homo sapiens]gi|21361397|ref|NP_037409.2| Rac GTPase activating protein 1 [Homo sapiens]gi|12053101|emb|CAB66728.1| hypothetical protein [Homo sapiens]gi|49065556|emb|CAG38596.1| RACGAP1 [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 Rac GTPase-activating protein 1 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_013277) Rac GTPase activating protein 1; GTPase activating protein [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Rac GTPase activating protein 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Hypothetical protein DKFZp434C011 [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta]
  • Rac GTPase activating protein 1; GTPase activating protein [Homo sapiens] [HumanGallus06162005.fasta]
  • Rac GTPase-activating protein 1 (MgcRacGAP) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Rac GTPase activating protein 1, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • RACGAP1 protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • RACGAP1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • hypothetical protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 HYPOTHETICAL PROTEIN DKFZP434C011 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Rac GTPase-activating protein 1; AltName: Full=Male germ cell RacGap; Short=MgcRacGAP [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=RACGAP1 Rac GTPase-activating protein 1 [human-ipi-250309-contam.fasta]
  • IPI:IPI00152946.1|SWISS-PROT:Q9H0H5|TREMBL:B2RE34|ENSEMBL:ENSP00000309871;ENSP00000404190;ENSP00000404808;ENSP00000413241|REFSEQ:NP_001119575;NP_001119576;NP_037409|H-INV:HIT000025390|VEGA:OTTHUMP00000167479;OTTHUMP00000167480;OTTHUMP00000167483 Tax_Id=96 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=RACGAP1 Rac GTPase-activating protein 1 ENSG00000161800 IPI00152946 IPI00792125 IPI00793957 IPI00386477 [drosphohumanreversed.fasta]
  • rac GTPase-activating protein 1 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q9H0H5;Q6PJ26;Q9NWN2;Q9P250;Q9P2W2; RecName: Full=Rac GTPase-activating protein 1; AltName: Full=Male germ cell RacGap; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Rac GTPase-activating protein 1 OS=Homo sapiens GN=RACGAP1 [011711_HMR.fasta]
  • IPI:IPI00152946.1|SWISS-PROT:Q9H0H5|TREMBL:B2RE34|ENSEMBL:ENSP00000309871;ENSP00000404190;ENSP00000404808;ENSP00000413241|REFSEQ:NP_001119575;NP_001119576;NP_037409|H-INV:HIT000025390|VEGA:OTTHUMP00000167479;OTTHUMP00000167480;OTTHUMP00000167483 Tax_Id=9606 Gene_Symbol=RACGAP1 Rac GTPase-activating protein 1 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=RACGAP1 Synonyms=HsCYK-4|ID-GAP|MgcRacGAP rac GTPase-activating protein 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00152946.1|SWISS-PROT:Q9H0H5|TREMBL:B2RE34|ENSEMBL:ENSP00000309871;ENSP00000404190;ENSP00000404808;ENSP00000413241;ENSP00000449370;ENSP00000449374|REFSEQ:NP_001119575;NP_001119576;NP_037409|H-INV:HIT000025390 Tax_Id=9606 Gene_Symbol=RACGAP1 Rac GTPase-activating protein 1 [ipi.HUMAN.20110912.fasta]
  • Rac GTPase-activating protein 1 GN=RACGAP1 [Doctor+uniprot-HUMAN-120911.fasta]
  • Rac GTPase activating protein 1, isoform CRA_a OS=Homo sapiens GN=RACGAP1 PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 632 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTMMLNVRN LFEQLVRRVE ILSEGNEVQF IQLAKDFEDF RKKWQRTDHE LGKYKDLLMK  60
   61 AETERSALDV KLKHARNQVD VEIKRRQRAE ADCEKLERQI QLIREMLMCD TSGSIQLSEE 120
  121 QKSALAFLNR GQPSSSNAGN KRLSTIDESG SILSDISFDK TDESLDWDSS LVKTFKLKKR 180
  181 EKRRSTSRQF VDGPPGPVKK TRSIGSAVDQ GNESIVAKTT VTVPNDGGPI EAVSTIETVP 240
  241 YWTRSRRKTG TLQPWNSDST LNSRQLEPRT ETDSVGTPQS NGGMRLHDFV SKTVIKPESC 300
  301 VPCGKRIKFG KLSLKCRDCR VVSHPECRDR CPLPCIPTLI GTPVKIGEGM LADFVSQTSP 360
  361 MIPSIVVHCV NEIEQRGLTE TGLYRISGCD RTVKELKEKF LRVKTVPLLS KVDDIHAICS 420
  421 LLKDFLRNLK EPLLTFRLNR AFMEAAEITD EDNSIAAMYQ AVGELPQANR DTLAFLMIHL 480
  481 QRVAQSPHTK MDVANLAKVF GPTIVAHAVP NPDPVTMLQD IKRQPKVVER LLSLPLEYWS 540
  541 QFMMVEQENI DPLHVIENSN AFSTPQTPDI KVSLLGPVTT PEHQLLKTPS SSSLSQRVRS 600
  601 TLTKNTPRFG SKSKSATNLG RQGNFFASPM LK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..159] PSI-BLAST 7.69897 Heavy meromyosin subfragment
    2 View Details [160..249] deduced N/A No confident structure predictions are available.
    3 View Details [250..345] PSI-BLAST 3.69897 NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE
    4 View Details [346..548] PSI-BLAST 42.09691 No description for 2ovjA was found.
    5 View Details [549..632] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.79128751898373 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.70614727793157 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.68579854252375 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  2.06038764955701 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.9750017471254 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.95738547986197 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.27693544428588 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  1.09070479183477 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.08577758274384 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.958295643211986 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.717730683557543 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.480348726111787 bayes_pls_golite062009
  • DNA binding
    		•  0.418154636457321 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.298334474872045 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle