Protein Overview: SPAST

General Information:
Name(s) found:	SPAST [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|6273493\|emb\|CAB60208.1\| spastin protein [Homo sapiens] [NCBI NR] gi\|6273491\|emb\|CAB60141.1\| spastin protein [Homo sapiens] [NCBI NR] gi\|12230611\|sp\|Q9UBP0.1\|SPAST_HUMAN RecName: Full=Spastin [NCBI NR] gi\|119620866\|gb\|EAX00461.1\| spastin, isoform CRA_a [Homo sapiens] [NCBI NR] gi\|11875211\|ref\|NP_055761.2\| spastin isoform 1 [Homo sapiens] [NCBI NR] spastin [HGNC (HUGO)] (Q9UBP0) Spastin [Swiss-Prot] Spastin OS=Homo sapiens GN=SPAST PE=1 SV=1 [Swiss-Prot] Splice isoform 1 of Q9UBP0 [hmr_yeast5_DM3-1_pombe.fasta] spastin isoform 1 [HMR_022704.fasta] spastin isoform 1 [Homo sapiens]gi\|6273493\|emb\|CAB60208.1\| spastin protein [Homo sapiens]gi\|6273491\|emb\|CAB60141.1\| spastin protein [Homo sapiens]gi\|12230611\|sp\|Q9UBP0\|SPAS_HUMAN Spastin [nrdb_11152004_Chlamydomonas] Spastin [Yateslab_human_na_07-28-2006_reversed.fasta] Tax_Id=9606 Splice Isoform 1 of Spastin [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] (NM_014946) spastin [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] spastin isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] spastin, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] spastin protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 Isoform 1 of Spastin [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta] Tax_Id=9606 SPLICE ISOFORM 1 OF SPASTIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] RecName: Full=Spastin [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=SPAST Isoform 1 of Spastin [human-ipi-250309-contam.fasta] IPI:IPI00002707.1\|SWISS-PROT:Q9UBP0-1\|ENSEMBL:ENSP00000320885\|REFSEQ:NP_055761\|H-INV:HIT000245911\|VEGA:OTTHUMP00000158571 Tax_Id=9606 Gene_Symbol=SPAST Isoform 1 of Spastin [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=SPAST Isoform 1 of Spastin ENSG00000021574 IPI00219816 IPI00002707 [drosphohumanreversed.fasta] Q9UBP0;A7E2A7;Q9UPR9; RecName: Full=Spastin; AltName: Full=Spastic paraplegia 4 protein; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Isoform 1 of Spastin OS=Homo sapiens GN=SPAST [011711_HMR.fasta] GeneSymbol=SPAST Synonyms=ADPSP\|FSP2\|KIAA1083\|SPG4 spastin isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] IPI:IPI00002707.1\|SWISS-PROT:Q9UBP0-1\|TREMBL:E5KRP5\|ENSEMBL:ENSP00000320885\|REFSEQ:NP_055761\|H-INV:HIT000245911\|VEGA:OTTHUMP00000158571 Tax_Id=9606 Gene_Symbol=SPAST Isoform 1 of Spastin [ipi.HUMAN.20110912.fasta] Spastin GN=SPAST [Doctor+uniprot-HUMAN-120911.fasta] Spastin OS=Homo sapiens GN=SPAST PE=3 SV=1 [uniprot-human-031015-contam.fasta]
Organism:	Homo sapiens
Length:	616 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSPGGRGKK KGSGGASNPV PPRPPPPCLA PAPPAAGPAP PPESPHKRNL YYFSYPLFVG  60
   61 FALLRLVAFH LGLLFVWLCQ RFSRALMAAK RSSGAAPAPA SASAPAPVPG GEAERVRVFH 120
  121 KQAFEYISIA LRIDEDEKAG QKEQAVEWYK KGIEELEKGI AVIVTGQGEQ CERARRLQAK 180
  181 MMTNLVMAKD RLQLLEKMQP VLPFSKSQTD VYNDSTNLAC RNGHLQSESG AVPKRKDPLT 240
  241 HTSNSLPRSK TVMKTGSAGL SGHHRAPSYS GLSMVSGVKQ GSGPAPTTHK GTPKTNRTNK 300
  301 PSTPTTATRK KKDLKNFRNV DSNLANLIMN EIVDNGTAVK FDDIAGQDLA KQALQEIVIL 360
  361 PSLRPELFTG LRAPARGLLL FGPPGNGKTM LAKAVAAESN ATFFNISAAS LTSKYVGEGE 420
  421 KLVRALFAVA RELQPSIIFI DEVDSLLCER REGEHDASRR LKTEFLIEFD GVQSAGDDRV 480
  481 LVMGATNRPQ ELDEAVLRRF IKRVYVSLPN EETRLLLLKN LLCKQGSPLT QKELAQLARM 540
  541 TDGYSGSDLT ALAKDAALGP IRELKPEQVK NMSASEMRNI RLSDFTESLK KIKRSVSPQT 600
  601 LEAYIRWNKD FGDTTV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	gi\|14317902, gi\|...	No Comments	Cheeseman, I.M., et al. (2004)
View Run	MIS12	No Comments	Cheeseman, I.M., et al. (2004)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..108]	deduced	N/A	No confident structure predictions are available.
2	View Details	[109..220]	FFAS03	3.42	No description for 2dl1A was found.
3	View Details	[221..320]	deduced	N/A	No confident structure predictions are available.
4	View Details	[321..616]	PSI-BLAST	59.154902	No description for 2qp9X was found.

Protein Overview: SPAST

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: