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Protein Overview: HUS1

General Information:
Name(s) found: HUS1 [HGNC (HUGO)]
Description(s) found:
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  • gi|74735462|sp|O60921.1|HUS1_HUMAN RecName: Full=Checkpoint protein HUS1; Short=hHUS1 [NCBI NR]
  • gi|54695834|gb|AAV38289.1| HUS1 checkpoint homolog (S. pombe) [Homo sapiens] [NCBI NR]
  • gi|54695832|gb|AAV38288.1| HUS1 checkpoint homolog (S. pombe) [Homo sapiens] [NCBI NR]
  • gi|51094553|gb|EAL23807.1| HUS1 checkpoint homolog (S. pombe) [Homo sapiens] [NCBI NR]
  • gi|49168588|emb|CAG38789.1| HUS1 [Homo sapiens] [NCBI NR]
  • gi|4758576|ref|NP_004498.1| HUS1 checkpoint protein [Homo sapiens] [NCBI NR]
  • gi|4585257|gb|AAD25350.1| HUS1 checkpoint protein [Homo sapiens] [NCBI NR]
  • gi|4019217|gb|AAC95526.1| Hus1-like protein [Homo sapiens] [NCBI NR]
  • gi|2980665|emb|CAA76518.1| hus1+-like [Homo sapiens] [NCBI NR]
  • gi|238537833|pdb|3G65|C Chain C, Crystal Structure Of The Human Rad9-Rad1-Hus1 Dna Damage Checkpoint Complex [NCBI NR]
  • gi|20303096|gb|AAM18968.1|AF503165_1 HUS1 checkpoint homolog (S. pombe) [Homo sapiens] [NCBI NR]
  • gi|158261941|dbj|BAF83148.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|13937824|gb|AAH07013.1| HUS1 checkpoint homolog (S. pombe) [Homo sapiens] [NCBI NR]
  • gi|119581406|gb|EAW61002.1| HUS1 checkpoint homolog (S. pombe), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119581405|gb|EAW61001.1| HUS1 checkpoint homolog (S. pombe), isoform CRA_a [Homo sapiens] [NCBI NR]
  • HUS1 checkpoint homolog (S. pombe) [HGNC (HUGO)]
  • Checkpoint protein HUS1 OS=Homo sapiens GN=HUS1 PE=1 SV=1 [Swiss-Prot]
  • HUS1+-like protein [hmr_yeast5_DM3-1_pombe.fasta]
  • HUS1 checkpoint protein; HUS1 (S. pombe) checkpoint homolog; hus1+-like protein [HMR_022704.fasta]
  • HUS1 checkpoint homolog (S. pombe) [Homo sapiens]gi|54695832|gb|AAV38288.1| HUS1 checkpoint homolog (S. pombe) [Homo sapiens]gi|51094553|gb|EAL23807.1| HUS1 checkpoint homolog (S. pombe) [Homo sapiens]gi|4758576|ref|NP_004498.1| HUS1 checkpoint protein [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 Checkpoint protein HUS1 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_004507) HUS1 checkpoint homolog (S. pombe); HUS1 (S. pombe) checkpoint homolog [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • HUS1 checkpoint protein [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Hus1+-like protein [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta]
  • HUS1 checkpoint protein; HUS1 (S. pombe) checkpoint homolog; hus1+-like protein [Homo sapiens] [HumanGallus06162005.fasta]
  • Checkpoint protein HUS1 (hHUS1) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • HUS1 checkpoint homolog (S. pombe), isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • HUS1 checkpoint homolog (S. pombe) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • HUS1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • hus1+-like [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Hus1-like protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 HUS1+-LIKE PROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=HUS1 Checkpoint protein HUS1 [human-ipi-250309-contam.fasta]
  • IPI:IPI00004712.1|SWISS-PROT:O60921|TREMBL:A4D2F2|ENSEMBL:ENSP00000258774;ENSP00000403844|REFSEQ:NP_004498|H-INV:HIT000299183|VEGA:OTTHUMP00000025475;OTTHUMP00000208364;OTTHUMP00000208378 Tax_Id=9606 Gene_Symbol=HUS1 Checkpoint protein HUS1 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=HUS1 Checkpoint protein HUS1 ENSG00000136273 IPI00004712 [drosphohumanreversed.fasta]
  • checkpoint protein HUS1 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • O60921; RecName: Full=Checkpoint protein HUS1; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Checkpoint protein HUS1 OS=Homo sapiens GN=HUS1 [011711_HMR.fasta]
  • GeneSymbol=HUS1 Synonyms=hHUS1 checkpoint protein HUS1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00004712.1|SWISS-PROT:O60921|TREMBL:A4D2F2|ENSEMBL:ENSP00000258774;ENSP00000403844|REFSEQ:NP_004498|H-INV:HIT000299183|VEGA:OTTHUMP00000208364;OTTHUMP00000208378 Tax_Id=9606 Gene_Symbol=HUS1 Checkpoint protein HUS1 [ipi.HUMAN.20110912.fasta]
  • Checkpoint protein HUS1 GN=HUS1 [Doctor+uniprot-HUMAN-120911.fasta]
  • HUS1 checkpoint homolog (S. pombe) OS=Homo sapiens GN=HUS1 PE=2 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 280 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFRAKIVDG ACLNHFTRIS NMIAKLAKTC TLRISPDKLN FILCDKLANG GVSMWCELEQ  60
   61 ENFFNEFQME GVSAENNEIY LELTSENLSR ALKTAQNARA LKIKLTNKHF PCLTVSVELL 120
  121 SMSSSSRIVT HDIPIKVIPR KLWKDLQEPV VPDPDVSIYL PVLKTMKSVV EKMKNISNHL 180
  181 VIEANLDGEL NLKIETELVC VTTHFKDLGN PPLASESTHE DRNVEHMAEV HIDIRKLLQF 240
  241 LAGQQVNPTK ALCNIVNNKM VHFDLLHEDV SLQYFIPALS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..280] FFAS03 4.4 Prolifirating cell nuclear antigen (PCNA)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  4.54147976644866 bayes_pls_golite062009
  • DNA polymerase activity
    		•  4.49701701569573 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  3.19456659721176 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  2.9050188778268 bayes_pls_golite062009
  • DNA polymerase processivity factor activity
    		•  2.66337934286498 bayes_pls_golite062009
  • transferase activity
    		•  2.40946730896889 bayes_pls_golite062009
  • DNA binding
    		•  2.04318251261279 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.01144876655621 bayes_pls_golite062009
  • binding
    		•  1.89545142352738 bayes_pls_golite062009
  • protein binding
    		•  1.506175977955 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.747485459405256 bayes_pls_golite062009
  • catalytic activity
    		•  0.474398499157949 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.397447452409526 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.360278840045828 bayes_pls_golite062009
  • DNA insertion or deletion binding
    		•  0.130265364927567 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle