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Protein Overview: CCL21

General Information:
Name(s) found: CCL21 [HGNC (HUGO)]
Description(s) found:
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  • gi|6094386|sp|O00585.1|CCL21_HUMAN RecName: Full=C-C motif chemokine 21; AltName: Full=Small-inducible cytokine A21; AltName: Full=Beta chemokine exodus-2; AltName: Full=6Ckine; AltName: Full=Secondary lymphoid-tissue chemokine; Short=SLC; Flags: Precurso [NCBI NR]
  • gi|55663290|emb|CAH69863.1| chemokine (C-C motif) ligand 21 [Homo sapiens] [NCBI NR]
  • gi|47496599|emb|CAG29322.1| CCL21 [Homo sapiens] [NCBI NR]
  • gi|4506835|ref|NP_002980.1| small inducible cytokine A21 precursor [Homo sapiens] [NCBI NR]
  • gi|4128129|emb|CAA06653.1| secondary lymphoid tissue chemokine [Homo sapiens] [NCBI NR]
  • gi|37182892|gb|AAQ89246.1| SLC chemokine [Homo sapiens] [NCBI NR]
  • gi|33337519|gb|AAQ13417.1| Efficient Chemoattractant for Lymphocytes; ECL [Homo sapiens] [NCBI NR]
  • gi|2624925|gb|AAB86594.1| beta chemokine [Homo sapiens] [NCBI NR]
  • gi|2335035|dbj|BAA21817.1| CC chemokine ligand 21 [Homo sapiens] [NCBI NR]
  • gi|2196920|gb|AAB91454.1| beta chemokine Exodus-2 [Homo sapiens] [NCBI NR]
  • gi|20381254|gb|AAH27918.1| Chemokine (C-C motif) ligand 21 [Homo sapiens] [NCBI NR]
  • gi|189053220|dbj|BAG34842.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|119578819|gb|EAW58415.1| chemokine (C-C motif) ligand 21 [Homo sapiens] [NCBI NR]
  • gi|117606582|gb|ABK41948.1| chemokine (C-C motif) ligand 21 [Homo sapiens] [NCBI NR]
  • chemokine (C-C motif) ligand 21 [HGNC (HUGO)]
  • (O00585) Small inducible cytokine A21 precursor (CCL21) (Beta chemokine exodus-2) (6Ckine) (Secondary lymphoid-tissue chemokine) (SLC) (UNQ784/PRO1600) [Swiss-Prot]
  • C-C motif chemokine 21 OS=Homo sapiens GN=CCL21 PE=1 SV=1 [Swiss-Prot]
  • Small inducible cytokine A21 precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • small inducible cytokine A21 precursor; exodus-2; beta chemokine exodus-2; 6Ckine; secondary lymphoid tissue chemokine; small inducible cytokine subfamily A (Cys-Cys), member 21 [HMR_022704.fasta]
  • small inducible cytokine A21 precursor; small inducible cytokine subfamily A (Cys-Cys), member 21; beta chemokine exodus-2; 6Ckine; secondary lymphoid tissue chemokine; exodus-2 [Human2242005.fasta]
  • SLC chemokine [Homo sapiens]gi|4506835|ref|NP_002980.1| small inducible cytokine A21 precursor [Homo sapiens]gi|55663290|emb|CAH69863.1| chemokine (C-C motif) ligand 21 [Homo sapiens]gi|20381254|gb|AAH27918.1| Small inducible cytokine A21, precursor [H [nrdb_11152004_Chlamydomonas]
  • Small inducible cytokine A21 precursor (CCL21) (Beta chemokine exodus-2) (6Ckine) (Secondary lymphoid-tissue chemokine) (SLC) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Small inducible cytokine A21 precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_002989) small inducible cytokine subfamily A (Cys-Cys), member 21 precursor; exodus-2; small inducible cytokine A21, precursor; beta chemokine exodus-2; 6Ckine; secondary lymphoid tissue chemokine [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • small inducible cytokine A21 precursor [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • small inducible cytokine A21 precursor; small inducible cytokine subfamily A (Cys-Cys), member 21; beta chemokine exodus-2; 6Ckine; secondary lymphoid tissue chemokine; exodus-2 [Homo sapiens] [HumanGallus06162005.fasta]
  • small inducible cytokine A21 precursor; exodus-2; beta chemokine exodus-2; 6Ckine; secondary lymphoid tissue chemokine; small inducible cytokine subfamily A (Cys-Cys), member 21 [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • C-C motif chemokine 21 precursor (Small-inducible cytokine A21) (Beta chemokine exodus-2) (6Ckine) (Secondary lymphoid-tissue chemokine) (SLC) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • chemokine (C-C motif) ligand 21 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • secondary lymphoid tissue chemokine [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chemokine (C-C motif) ligand 21 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • CC chemokine ligand 21 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • CCL21 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Efficient Chemoattractant for Lymphocytes; ECL [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • SLC chemokine [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • beta chemokine Exodus-2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • beta chemokine [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 SMALL INDUCIBLE CYTOKINE A21 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=C-C motif chemokine 21; AltName: Full=Small-inducible cytokine A21; AltName: Full=Beta chemokine exodus-2; AltName: Full=6Ckine; AltName: Full=Secondary lymphoid-tissue chemokine; Short=SLC; Flags: Precursor [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=CCL21 C-C motif chemokine 21 [human-ipi-250309-contam.fasta]
  • IPI:IPI00012174.1|SWISS-PROT:O00585|TREMBL:Q6ICR7|ENSEMBL:ENSP00000259607|REFSEQ:NP_002980|H-INV:HIT000057980|VEGA:OTTHUMP00000021304 Tax_Id=9606 Gene_Symbol=CCL21 C-C motif chemokine 21 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=CCL21 Small-inducible cytokine A21 precursor ENSG00000137077 IPI00012174 IPI00641478 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=CCL21 Small inducible cytokine A21 precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • C-C motif chemokine 21 precursor [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • O00585; RecName: Full=C-C motif chemokine 21; AltName: Full=Small-inducible cytokine A21; AltName: Full=Beta chemokine exodus-2; AltName: Full=6Ckine; AltName: Full=Secondary lymphoid-tissue chemokine; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • C-C motif chemokine 21 OS=Homo sapiens GN=CCL21 [011711_HMR.fasta]
  • GeneSymbol=CCL21 Synonyms=6Ckine|CKb9|ECL|MGC34555|SCYA21|SLC|TCA4 C-C motif chemokine 21 precursor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • C-C motif chemokine 21 GN=CCL21 [Doctor+uniprot-HUMAN-120911.fasta]
  • CCL21 protein (Fragment) OS=Homo sapiens GN=CCL21 PE=2 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 134 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQSLALSLL ILVLAFGIPR TQGSDGGAQD CCLKYSQRKI PAKVVRSYRK QEPSLGCSIP  60
   61 AILFLPRKRS QAELCADPKE LWVQQLMQHL DKTPSPQKPA QGCRKDRGAS KTGKKGKGSK 120
  121 GCKRTERSQT PKGP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..134] PSI-BLAST 17.30103 SOLUTION NMR STRUCTURE OF EOTAXIN, MINIMIZED AVERAGE STRUCTURE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • chemokine activity
    		•  4.89918398910885 bayes_pls_golite062009
  • chemokine receptor binding
    		•  4.89918398910885 bayes_pls_golite062009
  • cytokine activity
    		•  4.83557343632317 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  4.76558176153203 bayes_pls_golite062009
  • binding
    		•  3.18185781962524 bayes_pls_golite062009
  • receptor binding
    		•  3.05971926490912 bayes_pls_golite062009
  • protein binding
    		•  2.65575365603289 bayes_pls_golite062009
  • interleukin-8 receptor binding
    		•  2.32709632592014 bayes_pls_golite062009
  • chemoattractant activity
    		•  1.20748075091352 bayes_pls_golite062009
  • signal transducer activity
    		•  0.0477394461694876 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.0477394461694876 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle