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Protein Overview: MED22

General Information:
Name(s) found: MED22 [HGNC (HUGO)]
Description(s) found:
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  • gi|6175074|sp|Q15528.2|MED22_HUMAN RecName: Full=Mediator of RNA polymerase II transcription subunit 22; AltName: Full=Mediator complex subunit 22; AltName: Full=Surfeit locus protein 5; Short=Surf-5 [NCBI NR]
  • gi|55958177|emb|CAI12827.1| mediator complex subunit 22 [Homo sapiens] [NCBI NR]
  • gi|3288468|emb|CAA11916.1| surf5b [Homo sapiens] [NCBI NR]
  • gi|3288452|emb|CAA12053.1| Surf5b [Homo sapiens] [NCBI NR]
  • gi|19557695|ref|NP_598395.1| mediator complex subunit 22 isoform b [Homo sapiens] [NCBI NR]
  • gi|193784892|dbj|BAG54045.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|119608465|gb|EAW88059.1| surfeit 5, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119608464|gb|EAW88058.1| surfeit 5, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119608463|gb|EAW88057.1| surfeit 5, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119608462|gb|EAW88056.1| surfeit 5, isoform CRA_a [Homo sapiens] [NCBI NR]
  • mediator complex subunit 22 [HGNC (HUGO)]
  • Surfeit locus protein 5 - Homo sapiens (Human) [Swiss-Prot]
  • (Q15528) Surfeit locus protein 5 [Swiss-Prot]
  • Mediator of RNA polymerase II transcription subunit 22 OS=Homo sapiens GN=MED22 PE=1 SV=2 [Swiss-Prot]
  • Splice isoform Surf5B of Q15528 [hmr_yeast5_DM3-1_pombe.fasta]
  • surfeit 5 isoform b; surfeit locus protein 5 [HMR_022704.fasta]
  • similar to surfeit 5 isoform b; surfeit locus protein 5 [HMR_022704.fasta]
  • surfeit 5 isoform b [Homo sapiens]gi|3288452|emb|CAA12053.1| Surf5b [Homo sapiens]gi|3288468|emb|CAA11916.1| surf5b [Homo sapiens]gi|6175074|sp|Q15528|SUR5_HUMAN Surfeit locus protein 5 [nrdb_11152004_Chlamydomonas]
  • Surfeit locus protein 5 [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform Surf5B of Surfeit locus protein 5 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_133640) surfeit 5 isoform b; surfeit locus protein 5 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • surfeit 5 isoform b [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • surfeit 5 isoform b; surfeit locus protein 5 [Homo sapiens] [HumanGallus06162005.fasta]
  • similar to surfeit 5 isoform b; surfeit locus protein 5 [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5) (Surf-5) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • mediator complex subunit 22 isoform b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • surf5b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • surfeit 5 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • surfeit 5, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Surf5b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform Surf5B of Surfeit locus protein 5 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF SURFEIT LOCUS PROTEIN 5 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Mediator of RNA polymerase II transcription subunit 22; AltName: Full=Mediator complex subunit 22; AltName: Full=Surfeit locus protein 5; Short=Surf-5 [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=MED22 Isoform Surf5B of Mediator of RNA polymerase II transcription subunit 22 [human-ipi-250309-contam.fasta]
  • IPI:IPI00018040.1|SWISS-PROT:Q15528-1|ENSEMBL:ENSP00000342343|REFSEQ:NP_598395|H-INV:HIT000044391|VEGA:OTTHUMP00000022480 Tax_Id=9606 Gene_Symbol=MED22 Isoform Surf5B of Mediator of RNA polymerase II transcription subunit 22 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=MED22 Isoform Surf5B of Mediator of RNA polymerase II transcription subunit 22 ENSG00000148297 IPI00219228 IPI00018040 IPI00644426 IPI00382721 IPI00645426 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=SURF5 Isoform Surf5B of Surfeit locus protein 5 [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • mediator of RNA polymerase II transcription subunit 22 isoform b [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q15528;B3KW83;B3KWX4;O76072;Q5T8U0; RecName: Full=Mediator of RNA polymerase II transcription subunit 22; AltName: Full=Mediator complex subunit 22; AltName: Full=Surfeit locus protein 5; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform Surf5B of Mediator of RNA polymerase II transcription subunit 22 OS=Homo sapiens GN=MED22 [011711_HMR.fasta]
  • IPI:IPI00018040.1|SWISS-PROT:Q15528-1|ENSEMBL:ENSP00000342343;ENSP00000420393|REFSEQ:NP_598395|H-INV:HIT000044391|VEGA:OTTHUMP00000022480 Tax_Id=9606 Gene_Symbol=MED22 Isoform Surf5B of Mediator of RNA polymerase II transcription subunit 22 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=MED22 Synonyms=MED24|MGC48682|SURF5|surf-5 mediator of RNA polymerase II transcription subunit 22 isoform b [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00018040.1|SWISS-PROT:Q15528-1|ENSEMBL:ENSP00000342343;ENSP00000399566;ENSP00000420393|REFSEQ:NP_598395|H-INV:HIT000044391|VEGA:OTTHUMP00000022480;OTTHUMP00000022483 Tax_Id=9606 Gene_Symbol=MED22 Isoform Surf5B of Mediator of RNA polymerase II transcription subunit 22 [ipi.HUMAN.20110912.fasta]
  • Mediator of RNA polymerase II transcription subunit 22 GN=MED22 [Doctor+uniprot-HUMAN-120911.fasta]
  • IPI:IPI00018040.1|SWISS-PROT:Q15528-1|ENSEMBL:ENSP00000342343;ENSP00000420393|REFSEQ:NP_598395|H-INV:HIT000044391|VEGA:OTTHUMP00000022480;OTTHUMP00000022483 Tax_Id=9606 Gene_Symbol=MED22 Isoform Surf5B of Mediator of RNA polymerase II transcription subunit 22 [ipi.HUMAN.fasta.20110927]
  • Surfeit 5, isoform CRA_a OS=Homo sapiens GN=SURF5 PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 200 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQQRALPQS KETLLQSYNK RLKDDIKSIM DNFTEIIKTA KIEDETQVSR ATQGEQDNYE  60
   61 MHVRAANIVR AGESLMKLVS DLKQFLILND FPSVNEAIDQ RNQQLRTLQE ECDRKLITLR 120
  121 DEISIDLYEL EEEYYSSSSS LCEANDLPLC EAYGRLDLDT DSADGLSAPL LASPEPSAGP 180
  181 LQVAAPAHSH AGGPGPTEHA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..141] Pfam 89.022276 No description for PF06179.3 was found. Confident ab initio structure predictions are available.
    2 View Details [142..200] MSA 1.009968 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle