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Protein Overview: LEP

General Information:
Name(s) found: LEP [HGNC (HUGO)]
Description(s) found:
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  • gi|730218|sp|P41159.1|LEP_HUMAN RecName: Full=Leptin; AltName: Full=Obesity factor; AltName: Full=Obese protein; Flags: Precursor [NCBI NR]
  • gi|62361689|gb|AAX81413.1| leptin (obesity homolog, mouse) [Homo sapiens] [NCBI NR]
  • gi|623332|gb|AAA60470.1| ob [NCBI NR]
  • gi|51095072|gb|EAL24315.1| leptin (obesity homolog, mouse) [Homo sapiens] [NCBI NR]
  • gi|46854679|gb|AAH69452.1| Leptin [Homo sapiens] [NCBI NR]
  • gi|46854318|gb|AAH69527.1| Leptin [Homo sapiens] [NCBI NR]
  • gi|4557715|ref|NP_000221.1| leptin precursor [Homo sapiens] [NCBI NR]
  • gi|38174530|gb|AAH60830.1| Leptin [Homo sapiens] [NCBI NR]
  • pir||LTHU leptin precursor - human [NCBI NR]
  • gi|1469860|dbj|BAA09787.1| leptin [Homo sapiens] [NCBI NR]
  • gi|1407583|dbj|BAA09839.1| ob protein [Homo sapiens] [NCBI NR]
  • gi|1226244|gb|AAC50400.1| obese protein [NCBI NR]
  • gi|119604046|gb|EAW83640.1| leptin (obesity homolog, mouse) [Homo sapiens] [NCBI NR]
  • leptin [HGNC (HUGO)]
  • (P41159) Leptin precursor (Obesity factor) (Obese protein) [Swiss-Prot]
  • Leptin OS=Homo sapiens GN=LEP PE=1 SV=1 [Swiss-Prot]
  • Leptin precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • leptin precursor; leptin (murine obesity homolog); obesity; obesity (murine homolog, leptin) [HMR_022704.fasta]
  • leptin (obesity homolog, mouse) [Homo sapiens]gi|4557715|ref|NP_000221.1| leptin precursor [Homo sapiens]gi|46854679|gb|AAH69452.1| Leptin, precursor [Homo sapiens]gi|46854318|gb|AAH69527.1| Leptin, precursor [Homo sapiens]gi|38174530|gb|AAH60830.1| L [nrdb_11152004_Chlamydomonas]
  • Leptin precursor (Obesity factor) (Obese protein) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Leptin precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_000230) leptin precursor; leptin (murine obesity homolog); obesity; obesity (murine homolog, leptin) [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • leptin precursor [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • leptin precursor; leptin (murine obesity homolog); obesity; obesity (murine homolog, leptin) [Homo sapiens] [HumanGallus06162005.fasta]
  • Leptin [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • leptin [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • leptin (obesity homolog, mouse) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • ob protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • obese protein [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • ob [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 LEPTIN PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=LEP Leptin [human-ipi-250309-contam.fasta]
  • Leptin (obesity homolog, mouse) [Homo sapiens] [nr-271106-contam.fasta]
  • IPI:IPI00012760.1|SWISS-PROT:P41159|TREMBL:A4D0Y8;B2R8Y2;Q4TVR7;Q6NT58|ENSEMBL:ENSP00000312652|REFSEQ:NP_000221|H-INV:HIT000219868|VEGA:OTTHUMP00000025418 Tax_Id=9606 Gene_Symbol=LEP Leptin [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=LEP Leptin precursor ENSG00000174697 IPI00012760 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=LEP Leptin precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • P41159;O15158;Q56A88; RecName: Full=Leptin; AltName: Full=Obesity factor; AltName: Full=Obese protein; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Leptin OS=Homo sapiens GN=LEP [011711_HMR.fasta]
  • IPI:IPI00012760.1|SWISS-PROT:P41159|TREMBL:A4D0Y8;B2R8Y2;D3HIE0;Q4TVR7;Q6NT58|ENSEMBL:ENSP00000312652|REFSEQ:NP_000221|H-INV:HIT000219868|VEGA:OTTHUMP00000025418 Tax_Id=9606 Gene_Symbol=LEP Leptin [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=LEP Synonyms=FLJ94114|OB|OBS leptin precursor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00012760.1|SWISS-PROT:P41159|TREMBL:A4D0Y8;B2R8Y2;Q4TVR7;Q6NT58|ENSEMBL:ENSP00000312652|REFSEQ:NP_000221|H-INV:HIT000219868|VEGA:OTTHUMP00000212285 Tax_Id=9606 Gene_Symbol=LEP Leptin [ipi.HUMAN.20110912.fasta]
  • Leptin GN=LEP [Doctor+uniprot-HUMAN-120911.fasta]
  • sp|P41159|LEP_HUMAN Leptin OS=Homo sapiens GN=LEP PE=1 SV=1 [uniprot.sptr.mouse.20130102]
  • IPI:IPI00012760.1|SWISS-PROT:P41159|TREMBL:A4D0Y8;B2R8Y2;D3HIE0;Q4TVR7;Q6NT58|ENSEMBL:ENSP00000312652|REFSEQ:NP_000221|H-INV:HIT000219868|VEGA:OTTHUMP00000212285 Tax_Id=9606 Gene_Symbol=LEP Leptin [ipi.HUMAN.fasta.20110927]
  • Leptin OS=Homo sapiens GN=LEP PE=3 SV=1 [uniprot-human-031015-contam.fasta]
  • P41159 Leptin OS=Homo sapiens GN=LEP PE=1 SV=1 [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • LEP OS=HUMAN GN=None PE=None SV=None [eshark_proteins_plusContam.fa]
    • Organism: Homo sapiens
    Length: 167 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHWGTLCGFL WLWPYLFYVQ AVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL  60
   61 DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP 120
  121 WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..167] PSI-BLAST 75.0 HUMAN OBESITY PROTEIN, LEPTIN

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytokine receptor binding
    		•  6.47223189691244 bayes_pls_golite062009
  • receptor binding
    		•  5.3304255990112 bayes_pls_golite062009
  • cytokine activity
    		•  5.1883241815362 bayes_pls_golite062009
  • growth factor activity
    		•  3.72884804690203 bayes_pls_golite062009
  • protein binding
    		•  3.26483713001551 bayes_pls_golite062009
  • hormone activity
    		•  2.52921243340076 bayes_pls_golite062009
  • binding
    		•  2.48265117231403 bayes_pls_golite062009
  • prolactin receptor binding
    		•  2.45721634350294 bayes_pls_golite062009
  • interleukin-6 receptor binding
    		•  1.35761970306312 bayes_pls_golite062009
  • growth hormone activity
    		•  0.858583061924711 bayes_pls_golite062009
  • interleukin-27 binding
    		•  0.814859517857 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor binding
    		•  0.749565138698391 bayes_pls_golite062009
  • catalytic activity
    		•  0.246169290135575 bayes_pls_golite062009
  • macrophage colony stimulating factor receptor binding
    		•  0.227887473647222 bayes_pls_golite062009
  • interleukin-12 binding
    		•  0.17299185486948 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle