Protein Overview: RRM1

General Information:
Name(s) found:	RRM1 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|4506749\|ref\|NP_001024.1\| ribonucleoside-diphosphate reductase M1 chain [Homo sapiens] [NCBI NR] gi\|36153\|emb\|CAA42180.1\| large subunit ribonucleotide reductase [Homo sapiens] [NCBI NR] gi\|36065\|emb\|CAA42118.1\| M1 subunit of ribonucleotide reductase [Homo sapiens] [NCBI NR] gi\|13676332\|gb\|AAH06498.1\| Ribonucleotide reductase M1 [Homo sapiens] [NCBI NR] gi\|132608\|sp\|P23921.1\|RIR1_HUMAN RecName: Full=Ribonucleoside-diphosphate reductase large subunit; AltName: Full=Ribonucleoside-diphosphate reductase subunit M1; AltName: Full=Ribonucleotide reductase large subunit [NCBI NR] gi\|119622988\|gb\|EAX02583.1\| ribonucleotide reductase M1 polypeptide [Homo sapiens] [NCBI NR] pir\|\|S16680 ribonucleoside-diphosphate reductase (EC 1.17.4.1) chain M1 - human [NCBI NR] ribonucleotide reductase M1 [HGNC (HUGO)] Ribonucleoside-diphosphate reductase large subunit OS=Homo sapiens GN=RRM1 PE=1 SV=1 [Swiss-Prot] Ribonucleoside-diphosphate reductase M1 chain [hmr_yeast5_DM3-1_pombe.fasta] ribonucleoside-diphosphate reductase M1 chain; ribonucleotide reductase, large subunit; ribonucleotide reductase, R1 subunit [HMR_022704.fasta] ribonucleoside-diphosphate reductase M1 chain [Homo sapiens]gi\|13676332\|gb\|AAH06498.1\| Ribonucleoside-diphosphate reductase M1 chain [Homo sapiens]gi\|36153\|emb\|CAA42180.1\| large subunit ribonucleotide reductase [Homo sapiens]gi\|36065\|emb\|CAA42118.1\| M1 [nrdb_11152004_Chlamydomonas] Ribonucleoside-diphosphate reductase large subunit (Ribonucleoside-diphosphate reductase M1 subunit) (Ribonucleotide reductase large chain) [Yateslab_human_na_07-28-2006_reversed.fasta] Tax_Id=9606 Ribonucleoside-diphosphate reductase large subunit [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] (NM_001033) ribonucleoside-diphosphate reductase M1 chain; ribonucleotide reductase, large subunit; ribonucleotide reductase, R1 subunit [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] ribonucleoside-diphosphate reductase M1 chain [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] ribonucleoside-diphosphate reductase M1 chain; ribonucleotide reductase, large subunit; ribonucleotide reductase, R1 subunit [Homo sapiens] [HumanGallus06162005.fasta] Ribonucleoside-diphosphate reductase large subunit (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Ribonucleotide reductase M1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] ribonucleotide reductase M1 polypeptide [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] large subunit ribonucleotide reductase [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] M1 subunit of ribonucleotide reductase [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M1 CHAIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] RecName: Full=Ribonucleoside-diphosphate reductase large subunit; AltName: Full=Ribonucleoside-diphosphate reductase subunit M1; AltName: Full=Ribonucleotide reductase large subunit [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=RRM1 Ribonucleoside-diphosphate reductase large subunit [human-ipi-250309-contam.fasta] Ribonucleotide reductase M1 polypeptide [Homo sapiens] [nr-271106-contam.fasta] IPI:IPI00013871.1\|SWISS-PROT:P23921\|TREMBL:B4DNN4;B4E0I8;Q53GZ5\|ENSEMBL:ENSP00000300738\|REFSEQ:NP_001024\|H-INV:HIT000322327\|VEGA:OTTHUMP00000164513 Tax_Id=9606 Gene_Symbol=RRM1 Ribonucleoside-diphosphate reductase large subunit [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=RRM1 Ribonucleoside-diphosphate reductase large subunit ENSG00000167325 IPI00013871 [drosphohumanreversed.fasta] ribonucleoside-diphosphate reductase large subunit [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] P23921;Q9UNN2; RecName: Full=Ribonucleoside-diphosphate reductase large subunit; AltName: Full=Ribonucleoside-diphosphate reductase subunit M1; AltName: Full=Ribonucleotide reductase large subunit; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Ribonucleoside-diphosphate reductase large subunit OS=Homo sapiens GN=RRM1 [011711_HMR.fasta] Ribonucleoside-diphosphate reductase large subunit n=25 Tax=Tetrapoda RepID=RIR1_HUMAN [UniProt_Xenopus_laevis_01-01-2011_reversed.fasta] GeneSymbol=RRM1 Synonyms=R1\|RIR1\|RR1 ribonucleoside-diphosphate reductase large subunit [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] IPI:IPI00013871.1\|SWISS-PROT:P23921\|TREMBL:B4E0I8;Q53GZ5\|ENSEMBL:ENSP00000300738\|REFSEQ:NP_001024\|H-INV:HIT000322327\|VEGA:OTTHUMP00000164513 Tax_Id=9606 Gene_Symbol=RRM1 Ribonucleoside-diphosphate reductase large subunit [ipi.HUMAN.20110912.fasta] Ribonucleoside-diphosphate reductase large subunit GN=RRM1 [Doctor+uniprot-HUMAN-120911.fasta]
Organism:	Homo sapiens
Length:	792 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHVIKRDGRQ ERVMFDKITS RIQKLCYGLN MDFVDPAQIT MKVIQGLYSG VTTVELDTLA  60
   61 AETAATLTTK HPDYAILAAR IAVSNLHKET KKVFSDVMED LYNYINPHNG KHSPMVAKST 120
  121 LDIVLANKDR LNSAIIYDRD FSYNYFGFKT LERSYLLKIN GKVAERPQHM LMRVSVGIHK 180
  181 EDIDAAIETY NLLSERWFTH ASPTLFNAGT NRPQLSSCFL LSMKDDSIEG IYDTLKQCAL 240
  241 ISKSAGGIGV AVSCIRATGS YIAGTNGNSN GLVPMLRVYN NTARYVDQGG NKRPGAFAIY 300
  301 LEPWHLDIFE FLDLKKNTGK EEQRARDLFF ALWIPDLFMK RVETNQDWSL MCPNECPGLD 360
  361 EVWGEEFEKL YASYEKQGRV RKVVKAQQLW YAIIESQTET GTPYMLYKDS CNRKSNQQNL 420
  421 GTIKCSNLCT EIVEYTSKDE VAVCNLASLA LNMYVTSEHT YDFKKLAEVT KVVVRNLNKI 480
  481 IDINYYPVPE ACLSNKRHRP IGIGVQGLAD AFILMRYPFE SAEAQLLNKQ IFETIYYGAL 540
  541 EASCDLAKEQ GPYETYEGSP VSKGILQYDM WNVTPTDLWD WKVLKEKIAK YGIRNSLLIA 600
  601 PMPTASTAQI LGNNESIEPY TSNIYTRRVL SGEFQIVNPH LLKDLTERGL WHEEMKNQII 660
  661 ACNGSIQSIP EIPDDLKQLY KTVWEISQKT VLKMAAERGA FIDQSQSLNI HIAEPNYGKL 720
  721 TSMHFYGWKQ GLKTGMYYLR TRPAANPIQF TLNKEKLKDK EKVSKEEEEK ERNTAAMVCS 780
  781 LENRDECLMC GS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..792]	PSI-BLAST	1000.0	Structures of Yeast Ribonucloetide Reductase I

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: RRM1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: