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Protein Overview: POLR2B

General Information:
Name(s) found: POLR2B [HGNC (HUGO)]
Description(s) found:
Found 38 descriptions.
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  • polymerase (RNA) II (DNA directed) polypeptide B, 140kDa [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 1174 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYDADEDMQY DEDDDEITPD LWQEACWIVI SSYFDEKGLV RQQLDSFDEF IQMSVQRIVE  60
   61 DAPPIDLQAE AQHASGEVEE PPRYLLKFEQ IYLSKPTHWE RDGAPSPMMP NEARLRNLTY 120
  121 SAPLYVDITK TVIKEGEEQL QTQHQKTFIG KIPIMLRSTY CLLNGLTDRD LCELNECPLD 180
  181 PGGYFIINGS EKVLIAQEKM ATNTVYVFAK KDSKYAYTGE CRSCLENSSR PTSTIWVSML 240
  241 ARGGQGAKKS AIGQRIVATL PYIKQEVPII IVFRALGFVS DRDILEHIIY DFEDPEMMEM 300
  301 VKPSLDEAFV IQEQNVALNF IGSRGAKPGV TKEKRIKYAK EVLQKEMLPH VGVSDFCETK 360
  361 KAYFLGYMVH RLLLAALGRR ELDDRDHYGN KRLDLAGPLL AFLFRGMFKN LLKEVRIYAQ 420
  421 KFIDRGKDFN LELAIKTRII SDGLKYSLAT GNWGDQKKAH QARAGVSQVL NRLTFASTLS 480
  481 HLRRLNSPIG RDGKLAKPRQ LHNTLWGMVC PAETPEGHAV GLVKNLALMA YISVGSQPSP 540
  541 ILEFLEEWSM ENLEEISPAA IADATKIFVN GCWVGIHKDP EQLMNTLRKL RRQMDIIVSE 600
  601 VSMIRDIRER EIRIYTDAGR ICRPLLIVEK QKLLLKKRHI DQLKEREYNN YSWQDLVASG 660
  661 VVEYIDTLEE ETVMLAMTPD DLQEKEVAYC STYTHCEIHP SMILGVCASI IPFPDHNQSP 720
  721 RNTYQSAMGK QAMGVYITNF HVRMDTLAHV LYYPQKPLVT TRSMEYLRFR ELPAGINSIV 780
  781 AIASYTGYNQ EDSVIMNRSA VDRGFFRSVF YRSYKEQESK KGFDQEEVFE KPTRETCQGM 840
  841 RHAIYDKLDD DGLIAPGVRV SGDDVIIGKT VTLPENEDEL ESTNRRYTKR DCSTFLRTSE 900
  901 TGIVDQVMVT LNQEGYKFCK IRVRSVRIPQ IGDKFASRHG QKGTCGIQYR QEDMPFTCEG 960
  961 ITPDIIINPH AIPSRMTIGH LIECLQGKVS ANKGEIGDAT PFNDAVNVQK ISNLLSDYGY1020
 1021 HLRGNEVLYN GFTGRKITSQ IFIGPTYYQR LKHMVDDKIH SRARGPIQIL NRQPMEGRSR1080
 1081 DGGLRFGEME RDCQIAHGAA QFLRERLFEA SDPYQVHVCN LCGIMAIANT RTHTYECRGC1140
 1141 RNKTQISLVR MPYACKLLFQ ELMSMSIAPR MMSV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1174] PSI-BLAST 1000.0 RBP2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-directed RNA polymerase activity
    		•  10.2021663255698 bayes_pls_golite062009
  • RNA polymerase activity
    		•  10.2021663255698 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  7.6240729546188 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  6.31198922553685 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  5.44374972993429 bayes_pls_golite062009
  • transferase activity
    		•  4.83218811360621 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.34884279395902 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.33174616086951 bayes_pls_golite062009
  • DNA binding
    		•  2.27079409864244 bayes_pls_golite062009
  • binding
    		•  1.73416306650822 bayes_pls_golite062009
  • RNA polymerase II transcription mediator activity
    		•  1.53259746846673 bayes_pls_golite062009
  • catalytic activity
    		•  1.36406839864424 bayes_pls_golite062009
  • RNA binding
    		•  1.12618950637766 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.847783043631028 bayes_pls_golite062009
  • protein binding
    		•  0.45174975126993 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle