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Protein Overview: AHCY

General Information:
Name(s) found: AHCY [HGNC (HUGO)]
Description(s) found:
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  • gi|9951915|ref|NP_000678.1| adenosylhomocysteinase isoform 1 [Homo sapiens] [NCBI NR]
  • gi|31615498|pdb|1LI4|A Chain A, Human S-Adenosylhomocysteine Hydrolase Complexed With Neplanocin [NCBI NR]
  • gi|30582233|gb|AAP35343.1| S-adenosylhomocysteine hydrolase [Homo sapiens] [NCBI NR]
  • pir||A43629 adenosylhomocysteinase (EC 3.3.1.1) - human [NCBI NR]
  • gi|20141702|sp|P23526.4|SAHH_HUMAN RecName: Full=Adenosylhomocysteinase; Short=AdoHcyase; AltName: Full=S-adenosyl-L-homocysteine hydrolase [NCBI NR]
  • gi|178279|gb|AAA51682.1| S-adenosylhomocysteine hydrolase [Homo sapiens] [NCBI NR]
  • gi|158261867|dbj|BAF83111.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|15079562|gb|AAH11606.1| S-adenosylhomocysteine hydrolase [Homo sapiens] [NCBI NR]
  • gi|14603095|gb|AAH10018.1| S-adenosylhomocysteine hydrolase [Homo sapiens] [NCBI NR]
  • gi|119596686|gb|EAW76280.1| S-adenosylhomocysteine hydrolase, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119596685|gb|EAW76279.1| S-adenosylhomocysteine hydrolase, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|10241524|emb|CAC09528.1| S-adenosylhomocysteine hydrolase [Homo sapiens] [NCBI NR]
  • adenosylhomocysteinase [HGNC (HUGO)]
  • Adenosylhomocysteinase OS=Homo sapiens GN=AHCY PE=1 SV=4 [Swiss-Prot]
  • Adenosylhomocysteinase [hmr_yeast5_DM3-1_pombe.fasta]
  • S-adenosylhomocysteine hydrolase; adenosylhomocysteinase [HMR_022704.fasta]
  • S-adenosylhomocysteine hydrolase [Homo sapiens]gi|30582233|gb|AAP35343.1| S-adenosylhomocysteine hydrolase [Homo sapiens]gi|14603095|gb|AAH10018.1| S-adenosylhomocysteine hydrolase [Homo sapiens]gi|15079562|gb|AAH11606.1| S-adenosylhomocysteine hydrola [nrdb_11152004_Chlamydomonas]
  • Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • (NM_000687) S-adenosylhomocysteine hydrolase; adenosylhomocysteinase [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • S-adenosylhomocysteine hydrolase [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Adenosylhomocysteinase [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • S-adenosylhomocysteine hydrolase; adenosylhomocysteinase [Homo sapiens] [HumanGallus06162005.fasta]
  • Chain A, Human S-Adenosylhomocysteine Hydrolase Complexed With Neplanocin [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Adenosylhomocysteinase (AdoHcyase) (S-adenosyl-L-homocysteine hydrolase) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • S-adenosylhomocysteine hydrolase, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • S-adenosylhomocysteine hydrolase [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 ADENOSYLHOMOCYSTEINASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=AHCY Adenosylhomocysteinase [human-ipi-250309-contam.fasta]
  • adenosylhomocysteinase isoform 1 [Homo sapiens] [NCBI-RefSeq_human_na_07-13-2009_con_reversed.fasta]
  • AHCY [Homo sapiens] [nr-271106-contam.fasta]
  • IPI:IPI00012007.6|SWISS-PROT:P23526|TREMBL:A8K307;B3KUN3|ENSEMBL:ENSP00000217426|REFSEQ:NP_000678|H-INV:HIT000035325|VEGA:OTTHUMP00000030684 Tax_Id=9606 Gene_Symbol=AHCY Adenosylhomocysteinase [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=AHCY Adenosylhomocysteinase ENSG00000101444 IPI00012007 IPI00827743 [drosphohumanreversed.fasta]
  • P23526;A8K307;Q96A36; RecName: Full=Adenosylhomocysteinase; AltName: Full=S-adenosyl-L-homocysteine hydrolase; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Adenosylhomocysteinase OS=Homo sapiens GN=AHCY [011711_HMR.fasta]
  • IPI:IPI00012007.6|SWISS-PROT:P23526|TREMBL:B3KUN3|ENSEMBL:ENSP00000217426|REFSEQ:NP_000678|H-INV:HIT000035325|VEGA:OTTHUMP00000030684 Tax_Id=9606 Gene_Symbol=AHCY Adenosylhomocysteinase [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=AHCY Synonyms=SAHH adenosylhomocysteinase isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Adenosylhomocysteinase GN=AHCY [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 432 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDKLPYKVA DIGLAAWGRK ALDIAENEMP GLMRMRERYS ASKPLKGARI AGCLHMTVET  60
   61 AVLIETLVTL GAEVQWSSCN IFSTQDHAAA AIAKAGIPVY AWKGETDEEY LWCIEQTLYF 120
  121 KDGPLNMILD DGGDLTNLIH TKYPQLLPGI RGISEETTTG VHNLYKMMAN GILKVPAINV 180
  181 NDSVTKSKFD NLYGCRESLI DGIKRATDVM IAGKVAVVAG YGDVGKGCAQ ALRGFGARVI 240
  241 ITEIDPINAL QAAMEGYEVT TMDEACQEGN IFVTTTGCID IILGRHFEQM KDDAIVCNIG 300
  301 HFDVEIDVKW LNENAVEKVN IKPQVDRYRL KNGRRIILLA EGRLVNLGCA MGHPSFVMSN 360
  361 SFTNQVMAQI ELWTHPDKYP VGVHFLPKKL DEAVAEAHLG KLNVKLTKLT EKQAQYLGMS 420
  421 CDGPFKPDHY RY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..432] PSI-BLAST 159.0 S-adenosylhomocystein hydrolase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • adenosylhomocysteinase activity
    		•  4.75102111339352 bayes_pls_golite062009
  • trialkylsulfonium hydrolase activity
    		•  4.75102111339352 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.9367410227151 bayes_pls_golite062009
  • binding
    		•  0.784517759335365 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.418775403210681 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.32207755075663 bayes_pls_golite062009
  • DNA binding
    		•  0.158019531459925 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0191997392158629 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.012678711735872 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle