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Protein Overview: SEC61A1

General Information:
Name(s) found: SEC61A1 [HGNC (HUGO)]
Description(s) found:
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  • gi|7019415|ref|NP_037468.1| Sec61 alpha 1 subunit [Homo sapiens] [NCBI NR]
  • gi|57997153|emb|CAI46127.1| hypothetical protein [Homo sapiens] [NCBI NR]
  • gi|5106795|gb|AAD39847.1| sec61 homolog [Homo sapiens] [NCBI NR]
  • gi|48429109|sp|P61619.2|S61A1_HUMAN RecName: Full=Protein transport protein Sec61 subunit alpha isoform 1; Short=Sec61 alpha-1 [NCBI NR]
  • gi|193786666|dbj|BAG51989.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|193786535|dbj|BAG51318.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|13517989|gb|AAK29083.1|AF346602_1 Sec61 alpha form 1 [Homo sapiens] [NCBI NR]
  • gi|119599733|gb|EAW79327.1| Sec61 alpha 1 subunit (S. cerevisiae), isoform CRA_c [Homo sapiens] [NCBI NR]
  • gi|119599732|gb|EAW79326.1| Sec61 alpha 1 subunit (S. cerevisiae), isoform CRA_c [Homo sapiens] [NCBI NR]
  • Sec61 alpha 1 subunit (S. cerevisiae) [HGNC (HUGO)]
  • Protein transport protein Sec61 subunit alpha isoform 1 OS=Homo sapiens GN=SEC61A1 PE=1 SV=2 [Swiss-Prot]
  • Sec61 alpha form 1 [hmr_yeast5_DM3-1_pombe.fasta]
  • Sec61 alpha form 1; sec61 homolog; protein transport protein SEC61 alpha subunit isoform 1 [HMR_022704.fasta]
  • Sec61 alpha subunit homolog [Mus musculus]gi|7019415|ref|NP_037468.1| Sec61 alpha form 1 [Homo sapiens]gi|40538882|ref|NP_954865.1| Sec61 alpha subunit homolog [Rattus norvegicus]gi|206886|gb|AAA42125.1| sec61-like protein [Rattus sp.]gi|13277594|gb|A [nrdb_11152004_Chlamydomonas]
  • Protein transport protein Sec61 alpha subunit isoform 1 (Sec61 alpha-1) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Sec61 alpha 1 subunit [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_013336) Sec61 alpha form 1; sec61 homolog [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Sec61 alpha 1 subunit [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Sec61 alpha form 1; sec61 homolog; protein transport protein SEC61 alpha subunit isoform 1 [Homo sapiens] [HumanGallus06162005.fasta]
  • Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Sec61 alpha 1 subunit (S. cerevisiae), isoform CRA_c [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • hypothetical protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Sec61 alpha form 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • sec61 homolog [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 SEC61 ALPHA FORM 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • IPI:IPI00941172.1|SWISS-PROT:P61619-1|TREMBL:B3KNF6|ENSEMBL:ENSP00000243253|REFSEQ:NP_037468|H-INV:HIT000010695|VEGA:OTTHUMP00000172647 Tax_Id=9606 Gene_Symbol=SEC61A1 Isoform 1 of Protein transport protein Sec61 subunit alpha isoform 1 [ipi.HUMAN.fasta.20090807]
  • Tax_Id=9606 Isoform 1 of Protein transport protein Sec61 subunit alpha isoform 1 [IPI_human_3.26.fasta]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=SEC61A1 Isoform 1 of Protein transport protein Sec61 subunit alpha isoform 1 ENSG00000058262 IPI00218466 IPI00604476 IPI00791384 IPI00792005 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=SEC61A1 Isoform 1 of Protein transport protein Sec61 subunit alpha isoform 1 [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • protein transport protein Sec61 subunit alpha isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P61619;P38378;P57726;Q5JPF8;Q8N0Z4;Q8N3U3;Q8NC71;Q9BU16;Q9Y2R3; RecName: Full=Protein transport protein Sec61 subunit alpha isoform 1; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Protein transport protein Sec61 subunit alpha isoform 1 OS=Homo sapiens GN=SEC61A1 [011711_HMR.fasta]
  • Protein transport protein Sec61 subunit alpha isoform 1 n=45 Tax=Euteleostomi RepID=S61A1_HUMAN [UniProt_Xenopus_laevis_01-01-2011_reversed.fasta]
  • GeneSymbol=SEC61A1 Synonyms=HSEC61|SEC61|SEC61A protein transport protein Sec61 subunit alpha isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00941172.1|SWISS-PROT:P61619-1|TREMBL:B3KNF6|ENSEMBL:ENSP00000243253|REFSEQ:NP_037468|H-INV:HIT000010695|VEGA:OTTHUMP00000216015 Tax_Id=9606 Gene_Symbol=SEC61A1 Isoform 1 of Protein transport protein Sec61 subunit alpha isoform 1 [ipi.HUMAN.20110912.fasta]
  • Protein transport protein Sec61 subunit alpha isoform 1 GN=SEC61A1 [Doctor+uniprot-HUMAN-120911.fasta]
  • Sec61 alpha 1 subunit (S. cerevisiae), isoform CRA_c OS=Homo sapiens GN=SEC61A1 PE=2 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 476 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL FGIMSSDSAD  60
   61 PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII EVGDTPKDRA LFNGAQKLFG 120
  121 MIITIGQSIV YVMTGMYGDP SEMGAGICLL ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS 180
  181 LFIATNICET IVWKAFSPTT VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP 240
  241 NLMNLIATIF VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN 300
  301 LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES FGSVLEDPVH 360
  361 AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV MRGHRETSMV HELNRYIPTA 420
  421 AAFGGLCIGA LSVLADFLGA IGSGTGILLA VTIIYQYFEI FVKEQSEVGS MGALLF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..476] PSI-BLAST 72.0 The structure of a protein conducting channel

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ribonucleoprotein binding
    		•  5.96221631042313 bayes_pls_golite062009
  • protein transporter activity
    		•  5.55929343005534 bayes_pls_golite062009
  • transporter activity
    		•  3.32223562584466 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.22714325269757 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  2.12732472524264 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  2.12732472524264 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.76187269823414 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.67782980643723 bayes_pls_golite062009
  • binding
    		•  1.4562802789412 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.42890247609405 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  1.15847548838424 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  1.15316743403707 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.10003802565492 bayes_pls_golite062009
  • peptide transporter activity
    		•  1.01893828721893 bayes_pls_golite062009
  • protein binding
    		•  0.674651002700028 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle