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View Structure Prediction Details

Protein: SEC61A1
Organism: Homo sapiens
Length: 476 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEC61A1.

Description E-value Query
Range		 Subject
Range
gi|109088214 - gi|109088214|ref|XP_001085071.1| PREDICTED: similar to dehydrogenase E1 and transketolase domain con...
 0.0 [1..476] [1011..1486]
gi|73949146 - gi|73949146|ref|XP_535191.2| PREDICTED: similar to Sec61, alpha subunit 2 [Canis familiaris]
 0.0 [3..476] [78..551]
gi|114589143 - gi|114589143|ref|XP_516725.2| PREDICTED: similar to sec61-like protein [Pan troglodytes]
 0.0 [3..476] [114..587]
gi|50798652 - gi|50798652|ref|XP_424024.1| PREDICTED: similar to Sec61 alpha isoform 2, partial [Gallus gallus]
 0.0 [1..476] [65..540]
gi|52345506, gi|... - gi|89271300|emb|CAJ82441.1| Sec61 alpha 1 subunit (S. cerevisiae) [Xenopus tropicalis], gi|52345506|...
 0.0 [1..476] [1..476]
S61A2_MOUSE - Protein transport protein Sec61 subunit alpha isoform 2 OS=Mus musculus GN=Sec61a2 PE=2 SV=3
gi|34876835 - gi|34876835|ref|XP_341559.1| PREDICTED: similar to Sec61, alpha subunit 2 [Rattus norvegicus]
S61A2_BOVIN - Protein transport protein Sec61 subunit alpha isoform 2 OS=Bos taurus GN=SEC61A2 PE=2 SV=3
SEC61A2 - Sec61 alpha 2 subunit (S. cerevisiae)
 0.0 [1..476] [1..476]
S61A2_PONAB - Protein transport protein Sec61 subunit alpha isoform 2 OS=Pongo abelii GN=SEC61A2 PE=2 SV=1
gi|56403682 - gi|56403682|emb|CAI29636.1| hypothetical protein [Pongo abelii]
 0.0 [1..476] [1..476]

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Predicted Domain #1
Region A:
Residues: [1-476] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL FGIMSSDSAD  60
   61 PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII EVGDTPKDRA LFNGAQKLFG 120
  121 MIITIGQSIV YVMTGMYGDP SEMGAGICLL ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS 180
  181 LFIATNICET IVWKAFSPTT VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP 240
  241 NLMNLIATIF VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN 300
  301 LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES FGSVLEDPVH 360
  361 AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV MRGHRETSMV HELNRYIPTA 420
  421 AAFGGLCIGA LSVLADFLGA IGSGTGILLA VTIIYQYFEI FVKEQSEVGS MGALLF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.0
Match: 1rh5A
Description: The structure of a protein conducting channel
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ribonucleoprotein binding 5.96221631042313 bayes_pls_golite062009
protein transporter activity 5.55929343005534 bayes_pls_golite062009
transporter activity 3.32223562584466 bayes_pls_golite062009
substrate-specific transporter activity 3.22714325269757 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 2.12732472524264 bayes_pls_golite062009
macromolecule transmembrane transporter activity 2.12732472524264 bayes_pls_golite062009
protein transmembrane transporter activity 1.76187269823414 bayes_pls_golite062009
transmembrane transporter activity 1.67782980643723 bayes_pls_golite062009
binding 1.4562802789412 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.42890247609405 bayes_pls_golite062009
primary active transmembrane transporter activity 1.15847548838424 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 1.15316743403707 bayes_pls_golite062009
active transmembrane transporter activity 1.10003802565492 bayes_pls_golite062009
peptide transporter activity 1.01893828721893 bayes_pls_golite062009
protein binding 0.674651002700028 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle