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Protein Overview: WEE1

General Information:
Name(s) found: WEE1 [HGNC (HUGO)]
Description(s) found:
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  • gi|699108|gb|AAB60401.1| WEE1Hu CDK tyrosine 15-kinase [Homo sapiens] [NCBI NR]
  • gi|4507917|ref|NP_003381.1| WEE1 tyrosine kinase isoform 1 [Homo sapiens] [NCBI NR]
  • gi|1351419|sp|P30291.2|WEE1_HUMAN RecName: Full=Wee1-like protein kinase; AltName: Full=Wee1A kinase; AltName: Full=WEE1hu [NCBI NR]
  • gi|119588994|gb|EAW68588.1| WEE1 homolog (S. pombe), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119588992|gb|EAW68586.1| WEE1 homolog (S. pombe), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|10944890|emb|CAC14173.1| WEE1 protein [Homo sapiens] [NCBI NR]
  • pir||S55048 protein-tyrosine kinase (EC 2.7.1.112) WEE1 - human [NCBI NR]
  • WEE1 homolog (S. pombe) [HGNC (HUGO)]
  • Wee1-like protein kinase OS=Homo sapiens GN=WEE1 PE=1 SV=2 [Swiss-Prot]
  • Wee1-like protein kinase [hmr_yeast5_DM3-1_pombe.fasta]
  • wee1 tyrosine kinase; WEE1+ homolog (S. pombe); wee1-like protein kinase [HMR_022704.fasta]
  • wee1 tyrosine kinase; WEE1+ homolog (S. pombe); wee1-like protein kinase; wee1+ (S. pombe) homolog [071204_hmrz_cont.fasta]
  • wee1 tyrosine kinase [Homo sapiens]gi|10944890|emb|CAC14173.1| WEE1 protein [Homo sapiens]gi|1351419|sp|P30291|WEE1_HUMAN Wee1-like protein kinase (WEE1hu)gi|1085293|pir||S55048 protein-tyrosine kinase (EC 2.7.1.112) WEE1 - humangi|699108|gb|AAB60401. [nrdb_11152004_Chlamydomonas]
  • Wee1-like protein kinase (WEE1hu) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Wee1-like protein kinase [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_003390) wee1 tyrosine kinase; wee1-like protein kinase; WEE1+ homolog (S. pombe); WEE1 protein [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • wee1 tyrosine kinase [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • wee1 tyrosine kinase; WEE1+ homolog (S. pombe); wee1-like protein kinase; wee1+ (S. pombe) homolog [Homo sapiens] [HumanGallus06162005.fasta]
  • wee1 tyrosine kinase; WEE1+ homolog (S. pombe); wee1-like protein kinase [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • Wee1-like protein kinase (Wee1A kinase) (WEE1hu) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • WEE1 homolog (S. pombe), isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • WEE1 protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • WEE1Hu CDK tyrosine 15-kinase [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 WEE1-LIKE PROTEIN KINASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Wee1-like protein kinase; AltName: Full=Wee1A kinase; AltName: Full=WEE1hu [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • wee1 tyrosine kinase isoform 1 [Homo sapiens] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=WEE1 Wee1-like protein kinase [human-ipi-250309-contam.fasta]
  • WEE1 tyrosine kinase isoform 1 [Homo sapiens] [NCBI-RefSeq_human_na_07-13-2009_con_reversed.fasta]
  • IPI:IPI00025830.1|SWISS-PROT:P30291|TREMBL:Q6MZL0;Q6NSL2;Q86V29|ENSEMBL:ENSP00000402084|REFSEQ:NP_003381|H-INV:HIT000218015 Tax_Id=9606 Gene_Symbol=WEE1 Wee1-like protein kinase [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=WEE1 Wee1-like protein kinase ENSG00000166483 IPI00025830 [drosphohumanreversed.fasta]
  • wee1-like protein kinase isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P30291; RecName: Full=Wee1-like protein kinase; AltName: Full=Wee1A kinase; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Wee1-like protein kinase OS=Homo sapiens GN=WEE1 [011711_HMR.fasta]
  • IPI:IPI00025830.1|SWISS-PROT:P30291|TREMBL:D3DQV0;Q6MZL0;Q6NSL2;Q86V29|ENSEMBL:ENSP00000402084|REFSEQ:NP_003381|H-INV:HIT000218015 Tax_Id=9606 Gene_Symbol=WEE1 Wee1-like protein kinase [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=WEE1 Synonyms=DKFZp686I18166|FLJ16446|WEE1A|WEE1hu wee1-like protein kinase isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00025830.1|SWISS-PROT:P30291|TREMBL:Q6MZL0;Q6NSL2;Q86V29|ENSEMBL:ENSP00000402084|REFSEQ:NP_003381|H-INV:HIT000218015|VEGA:OTTHUMP00000231338 Tax_Id=9606 Gene_Symbol=WEE1 Wee1-like protein kinase [ipi.HUMAN.20110912.fasta]
  • Wee1-like protein kinase GN=WEE1 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 646 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFLSRQQPP PPRRAGAACT LRQKLIFSPC SDCEEEEEEE EEEGSGHSTG EDSAFQEPDS  60
   61 PLPPARSPTE PGPERRRSPG PAPGSPGELE EDLLLPGACP GADEAGGGAE GDSWEEEGFG 120
  121 SSSPVKSPAA PYFLGSSFSP VRCGGPGDAS PRGCGARRAG EGRRSPRPDH PGTPPHKTFR 180
  181 KLRLFDTPHT PKSLLSKARG IDSSSVKLRG SSLFMDTEKS GKREFDVRQT PQVNINPFTP 240
  241 DSLLLHSSGQ CRRRKRTYWN DSCGEDMEAS DYELEDETRP AKRITITESN MKSRYTTEFH 300
  301 ELEKIGSGEF GSVFKCVKRL DGCIYAIKRS KKPLAGSVDE QNALREVYAH AVLGQHSHVV 360
  361 RYFSAWAEDD HMLIQNEYCN GGSLADAISE NYRIMSYFKE AELKDLLLQV GRGLRYIHSM 420
  421 SLVHMDIKPS NIFISRTSIP NAASEEGDED DWASNKVMFK IGDLGHVTRI SSPQVEEGDS 480
  481 RFLANEVLQE NYTHLPKADI FALALTVVCA AGAEPLPRNG DQWHEIRQGR LPRIPQVLSQ 540
  541 EFTELLKVMI HPDPERRPSA MALVKHSVLL SASRKSAEQL RIELNAEKFK NSLLQKELKK 600
  601 AQMAKAAAEE RALFTDRMAT RSTTQSNRTS RLIGKKMNRS VSLTIY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..278] deduced N/A No confident structure predictions are available.
    2 View Details [279..578] PSI-BLAST 50.30103 Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824
    3 View Details [579..646] PSI-BLAST 59.0 G-protein coupled receptor kinase 2, N-terminal domain; G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1); G-protein coupled receptor kinase 2


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle