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Protein Overview: SAE1

General Information:
Name(s) found: SAE1 [HGNC (HUGO)]
Description(s) found:
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  • gi|60594172|pdb|1Y8R|D Chain D, Sumo E1 Activating Enzyme Sae1-Sae2-Sumo1-Mg-Atp Complex [NCBI NR]
  • gi|60594169|pdb|1Y8R|A Chain A, Sumo E1 Activating Enzyme Sae1-Sae2-Sumo1-Mg-Atp Complex [NCBI NR]
  • gi|60594167|pdb|1Y8Q|C Chain C, Sumo E1 Activating Enzyme Sae1-Sae2-Mg-Atp Complex [NCBI NR]
  • gi|60594165|pdb|1Y8Q|A Chain A, Sumo E1 Activating Enzyme Sae1-Sae2-Mg-Atp Complex [NCBI NR]
  • gi|4885585|ref|NP_005491.1| SUMO1 activating enzyme subunit 1 isoform a [Homo sapiens] [NCBI NR]
  • gi|4581064|gb|AAD23902.2|AF046025_1 activation of Sentrin/SUMO protein AOS1 [Homo sapiens] [NCBI NR]
  • gi|4580598|gb|AAD24433.1|AF110956_1 SUMO-1 activating enzyme subunit 1 [Homo sapiens] [NCBI NR]
  • gi|42559897|sp|Q9UBE0.1|SAE1_HUMAN RecName: Full=SUMO-activating enzyme subunit 1; AltName: Full=Ubiquitin-like 1-activating enzyme E1A [NCBI NR]
  • gi|30583419|gb|AAP35954.1| SUMO-1 activating enzyme subunit 1 [Homo sapiens] [NCBI NR]
  • gi|189055008|dbj|BAG37992.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|17390638|gb|AAH18271.1| SUMO1 activating enzyme subunit 1 [Homo sapiens] [NCBI NR]
  • gi|13177650|gb|AAH03611.1| SUMO1 activating enzyme subunit 1 [Homo sapiens] [NCBI NR]
  • gi|12653153|gb|AAH00344.1| SUMO1 activating enzyme subunit 1 [Homo sapiens] [NCBI NR]
  • gi|119577866|gb|EAW57462.1| SUMO-1 activating enzyme subunit 1, isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|119577865|gb|EAW57461.1| SUMO-1 activating enzyme subunit 1, isoform CRA_b [Homo sapiens] [NCBI NR]
  • SUMO1 activating enzyme subunit 1 [HGNC (HUGO)]
  • (Q9UBE0) Ubiquitin-like 1-activating enzyme E1A (SUMO-1-activating enzyme subunit 1) [Swiss-Prot]
  • SUMO-activating enzyme subunit 1 OS=Homo sapiens GN=SAE1 PE=1 SV=1 [Swiss-Prot]
  • SUMO-1 activating enzyme subunit 1 [hmr_yeast5_DM3-1_pombe.fasta]
  • SUMO-1 activating enzyme subunit 1; SUMO-1 activating enzyme E1 N subunit; sentrin/SUMO-activating protein AOS1; ubiquitin-like protein SUMO-1 activating enzyme [HMR_022704.fasta]
  • SUMO-1 activating enzyme subunit 1 [Homo sapiens]gi|30583419|gb|AAP35954.1| SUMO-1 activating enzyme subunit 1 [Homo sapiens]gi|17390638|gb|AAH18271.1| SUMO-1 activating enzyme subunit 1 [Homo sapiens]gi|12653153|gb|AAH00344.1| SUMO-1 activating enzyme [nrdb_11152004_Chlamydomonas]
  • Ubiquitin-like 1 activating enzyme E1A (SUMO-1 activating enzyme subunit 1) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Ubiquitin-like 1-activating enzyme E1A [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_005500) SUMO-1 activating enzyme subunit 1; SUMO-1 activating enzyme E1 N subunit; sentrin/SUMO-activating protein AOS1; ubiquitin-like protein SUMO-1 activating enzyme [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • SUMO-1 activating enzyme subunit 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Ubiquitin-like 1 activating enzyme E1A [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • SUMO-1 activating enzyme subunit 1; SUMO-1 activating enzyme E1 N subunit; sentrin/SUMO-activating protein AOS1; ubiquitin-like protein SUMO-1 activating enzyme [Homo sapiens] [HumanGallus06162005.fasta]
  • Chain D, Sumo E1 Activating Enzyme Sae1-Sae2-Sumo1-Mg-Atp Complex [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Sumo E1 Activating Enzyme Sae1-Sae2-Sumo1-Mg-Atp Complex [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain C, Sumo E1 Activating Enzyme Sae1-Sae2-Mg-Atp Complex [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Sumo E1 Activating Enzyme Sae1-Sae2-Mg-Atp Complex [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • SUMO1 activating enzyme subunit 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • SUMO-1 activating enzyme subunit 1, isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • activation of Sentrin/SUMO protein AOS1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 UBIQUITIN-LIKE 1 ACTIVATING ENZYME E1A [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • SUMO1 activating enzyme subunit 1 isoform a [Homo sapiens] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=SAE1 SUMO-activating enzyme subunit 1 [human-ipi-250309-contam.fasta]
  • Ubiquitin-like 1-activating enzyme E1A (SUMO-1-activating enzyme subunit 1) [nr-271106-contam.fasta]
  • IPI:IPI00033130.3|SWISS-PROT:Q9UBE0|TREMBL:B2RDP5;B4DY66|ENSEMBL:ENSP00000270225|REFSEQ:NP_005491|H-INV:HIT000064009|VEGA:OTTHUMP00000078003 Tax_Id=9606 Gene_Symbol=SAE1 SUMO-activating enzyme subunit 1 [ipi.HUMAN.fasta.20090807]
  • Tax_Id=9606 SUMO-activating enzyme subunit 1 [IPI_human_3.26.fasta]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=SAE1 SUMO-activating enzyme subunit 1 ENSG00000142230 IPI00033130 IPI00640965 IPI00647006 [drosphohumanreversed.fasta]
  • SUMO-activating enzyme subunit 1 isoform a [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q9UBE0;B2RDP5;O95717;Q9P020; RecName: Full=SUMO-activating enzyme subunit 1; AltName: Full=Ubiquitin-like 1-activating enzyme E1A; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • SUMO-activating enzyme subunit 1 OS=Homo sapiens GN=SAE1 [011711_HMR.fasta]
  • IPI:IPI00033130.3|SWISS-PROT:Q9UBE0|TREMBL:B4DY66|ENSEMBL:ENSP00000270225|REFSEQ:NP_005491|H-INV:HIT000064009|VEGA:OTTHUMP00000078003 Tax_Id=9606 Gene_Symbol=SAE1 SUMO-activating enzyme subunit 1 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=SAE1 Synonyms=AOS1|FLJ3091|HSPC140|SUA1|UBLE1A SUMO-activating enzyme subunit 1 isoform a [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00033130.3|SWISS-PROT:Q9UBE0|ENSEMBL:ENSP00000270225|REFSEQ:NP_005491|H-INV:HIT000064009 Tax_Id=9606 Gene_Symbol=SAE1 SUMO-activating enzyme subunit 1 [ipi.HUMAN.20110912.fasta]
  • SUMO-activating enzyme subunit 1 GN=SAE1 [Doctor+uniprot-HUMAN-120911.fasta]
  • SUMO-1 activating enzyme subunit 1, isoform CRA_b OS=Homo sapiens GN=SAE1 PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 346 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVEKEEAGGG ISEEEAAQYD RQIRLWGLEA QKRLRASRVL LVGLKGLGAE IAKNLILAGV  60
   61 KGLTMLDHEQ VTPEDPGAQF LIRTGSVGRN RAEASLERAQ NLNPMVDVKV DTEDIEKKPE 120
  121 SFFTQFDAVC LTCCSRDVIV KVDQICHKNS IKFFTGDVFG YHGYTFANLG EHEFVEEKTK 180
  181 VAKVSQGVED GPDTKRAKLD SSETTMVKKK VVFCPVKEAL EVDWSSEKAK AALKRTTSDY 240
  241 FLLQVLLKFR TDKGRDPSSD TYEEDSELLL QIRNDVLDSL GISPDLLPED FVRYCFSEMA 300
  301 PVCAVVGGIL AQEIVKALSQ RDPPHNNFFF FDGMKGNGIV ECLGPK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..346] PSI-BLAST 92.69897 SUMO E1 ACTIVATING ENZYME SAE1-SAE2-MG-ATP COMPLEX


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle