YRC Public Data Repository - Protein Structure Prediction

Protein:	SAE1
Organism:	Homo sapiens
Length:	346 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SAE1.

Description	E-value	Query Range	Subject Range
gi\|6841502, gi\|7... - gi\|7705473\|ref\|NP_057486.1\| SUMO1 activating enzyme subunit 1 isoform a [Homo sapiens], gi\|6841502\|g...	7.0E-91	[1..346]	[1..346]
gi\|55731582 - gi\|55731582\|emb\|CAH92498.1\| hypothetical protein [Pongo abelii] gi\|55731582\|emb\|... - hypothetical protein [Pongo pygmaeus]	8.0E-91	[1..346]	[1..346]
gi\|57036395 - gi\|57036395\|ref\|XP_533632.1\| PREDICTED: similar to Ubiquitin-like 1 activating enzyme E1A (SUMO-1 ac...	1.0E-89	[1..346]	[1..346]
SAE1_BOVIN - SUMO-activating enzyme subunit 1 OS=Bos taurus GN=SAE1 PE=2 SV=1	1.0E-89	[1..345]	[1..345]
SAE1_MOUSE - SUMO-activating enzyme subunit 1 OS=Mus musculus GN=Sae1 PE=1 SV=1	6.0E-87	[17..346]	[21..350]
SAE1_RAT - SUMO-activating enzyme subunit 1 OS=Rattus norvegicus GN=Sae1 PE=2 SV=1	1.0E-86	[17..346]	[20..349]
SAE1_XENLA - SUMO-activating enzyme subunit 1 OS=Xenopus laevis GN=sae1 PE=2 SV=1	1.0E-81	[1..346]	[1..344]

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Predicted Domain #1

Region A:
Residues: [1-346]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVEKEEAGGG ISEEEAAQYD RQIRLWGLEA QKRLRASRVL LVGLKGLGAE IAKNLILAGV  60
   61 KGLTMLDHEQ VTPEDPGAQF LIRTGSVGRN RAEASLERAQ NLNPMVDVKV DTEDIEKKPE 120
  121 SFFTQFDAVC LTCCSRDVIV KVDQICHKNS IKFFTGDVFG YHGYTFANLG EHEFVEEKTK 180
  181 VAKVSQGVED GPDTKRAKLD SSETTMVKKK VVFCPVKEAL EVDWSSEKAK AALKRTTSDY 240
  241 FLLQVLLKFR TDKGRDPSSD TYEEDSELLL QIRNDVLDSL GISPDLLPED FVRYCFSEMA 300
  301 PVCAVVGGIL AQEIVKALSQ RDPPHNNFFF FDGMKGNGIV ECLGPK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	92.69897
Match:	1y8qA
Description:	SUMO E1 ACTIVATING ENZYME SAE1-SAE2-MG-ATP COMPLEX
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits