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Protein Overview: POLH

General Information:
Name(s) found: POLH [HGNC (HUGO)]
Description(s) found:
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  • gi|59798441|sp|Q9Y253.1|POLH_HUMAN RecName: Full=DNA polymerase eta; AltName: Full=RAD30 homolog A; AltName: Full=Xeroderma pigmentosum variant type protein [NCBI NR]
  • gi|5729982|ref|NP_006493.1| DNA-directed DNA polymerase eta [Homo sapiens] [NCBI NR]
  • gi|57209081|emb|CAI42642.1| polymerase (DNA directed), eta [Homo sapiens] [NCBI NR]
  • gi|55958404|emb|CAI12787.1| polymerase (DNA directed), eta [Homo sapiens] [NCBI NR]
  • gi|5457144|gb|AAD43810.1|AF158185_1 xeroderma pigmentosum variant RAD30 [Homo sapiens] [NCBI NR]
  • gi|5138988|dbj|BAA81666.1| DNA polymerase eta [Homo sapiens] [NCBI NR]
  • gi|34732732|gb|AAQ81300.1| polymerase (DNA directed), eta [Homo sapiens] [NCBI NR]
  • gi|119624616|gb|EAX04211.1| polymerase (DNA directed), eta, isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|119624615|gb|EAX04210.1| polymerase (DNA directed), eta, isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|11463971|dbj|BAB18601.1| DNA polymerase eta [Homo sapiens] [NCBI NR]
  • polymerase (DNA directed), eta [HGNC (HUGO)]
  • DNA polymerase eta OS=Homo sapiens GN=POLH PE=1 SV=1 [Swiss-Prot]
  • DNA polymerase ETA [hmr_yeast5_DM3-1_pombe.fasta]
  • polymerase (DNA directed), eta [Homo sapiens]gi|5729982|ref|NP_006493.1| polymerase (DNA directed), eta [Homo sapiens]gi|11463971|dbj|BAB18601.1| DNA polymerase eta [Homo sapiens]gi|5457144|gb|AAD43810.1| xeroderma pigmentosum variant RAD30 [Homo sapie [nrdb_11152004_Chlamydomonas]
  • DNA polymerase eta (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of DNA polymerase eta [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_006502) polymerase (DNA directed), eta [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • polymerase (DNA directed), eta [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • polymerase (DNA directed), eta, isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • DNA polymerase eta [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • xeroderma pigmentosum variant RAD30 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of DNA polymerase eta [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 DNA POLYMERASE ETA [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=POLH Isoform 1 of DNA polymerase eta [human-ipi-250309-contam.fasta]
  • DNA-directed DNA polymerase eta [Homo sapiens] [NCBI-RefSeq_human_na_07-13-2009_con_reversed.fasta]
  • POLH [Homo sapiens] [nr-271106-contam.fasta]
  • IPI:IPI00008011.1|SWISS-PROT:Q9Y253-1|TREMBL:B3KN75;B3KVC6;B4DG64;B7ZA36|ENSEMBL:ENSP00000361310|REFSEQ:NP_006493|H-INV:HIT000058777|VEGA:OTTHUMP00000016478 Tax_Id=9606 Gene_Symbol=POLH Isoform 1 of DNA polymerase eta [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=POLH Isoform 1 of DNA polymerase eta ENSG00000170734 IPI00552037 IPI00008011 IPI00646080 [drosphohumanreversed.fasta]
  • Q9Y253;Q7L8E3;Q96BC4;Q9BX13; RecName: Full=DNA polymerase eta; AltName: Full=RAD30 homolog A; AltName: Full=Xeroderma pigmentosum variant type protein; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of DNA polymerase eta OS=Homo sapiens GN=POLH [011711_HMR.fasta]
  • GeneSymbol=POLH Synonyms=FLJ16395|FLJ21978|RAD30|RAD30A|XP-V|XPV DNA polymerase eta [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00008011.1|SWISS-PROT:Q9Y253-1|TREMBL:B3KN75;B7ZA36|ENSEMBL:ENSP00000361310|REFSEQ:NP_006493|H-INV:HIT000058777|VEGA:OTTHUMP00000016478 Tax_Id=9606 Gene_Symbol=POLH Isoform 1 of DNA polymerase eta [ipi.HUMAN.20110912.fasta]
  • DNA polymerase eta GN=POLH [Doctor+uniprot-HUMAN-120911.fasta]
  • Polymerase (DNA directed), eta, isoform CRA_b OS=Homo sapiens GN=POLH PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 713 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATGQDRVVA LVDMDCFFVQ VEQRQNPHLR NKPCAVVQYK SWKGGGIIAV SYEARAFGVT  60
   61 RSMWADDAKK LCPDLLLAQV RESRGKANLT KYREASVEVM EIMSRFAVIE RASIDEAYVD 120
  121 LTSAVQERLQ KLQGQPISAD LLPSTYIEGL PQGPTTAEET VQKEGMRKQG LFQWLDSLQI 180
  181 DNLTSPDLQL TVGAVIVEEM RAAIERETGF QCSAGISHNK VLAKLACGLN KPNRQTLVSH 240
  241 GSVPQLFSQM PIRKIRSLGG KLGASVIEIL GIEYMGELTQ FTESQLQSHF GEKNGSWLYA 300
  301 MCRGIEHDPV KPRQLPKTIG CSKNFPGKTA LATREQVQWW LLQLAQELEE RLTKDRNDND 360
  361 RVATQLVVSI RVQGDKRLSS LRRCCALTRY DAHKMSHDAF TVIKNCNTSG IQTEWSPPLT 420
  421 MLFLCATKFS ASAPSSSTDI TSFLSSDPSS LPKVPVTSSE AKTQGSGPAV TATKKATTSL 480
  481 ESFFQKAAER QKVKEASLSS LTAPTQAPMS NSPSKPSLPF QTSQSTGTEP FFKQKSLLLK 540
  541 QKQLNNSSVS SPQQNPWSNC KALPNSLPTE YPGCVPVCEG VSKLEESSKA TPAEMDLAHN 600
  601 SQSMHASSAS KSVLEVTQKA TPNPSLLAAE DQVPCEKCGS LVPVWDMPEH MDYHFALELQ 660
  661 KSFLQPHSSN PQVVSAVSHQ GKRNPKSPLA CTNKRPRPEG MQTLESFFKP LTH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..450] PSI-BLAST 89.69897 No description for 2oh2A was found.
    2 View Details [451..589] FFAS03 1.11 No description for 2j63A was found.
    3 View Details [590..713] MSA 5.211997 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle