YRC Public Data Repository - Protein Structure Prediction

Protein:	POLH
Organism:	Homo sapiens
Length:	713 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for POLH.

Description	E-value	Query Range	Subject Range
gi\|55626670 - gi\|55626670\|ref\|XP_518497.1\| PREDICTED: polymerase (DNA directed), eta isoform 4 [Pan troglodytes]	0.0	[1..713]	[1..713]
POLH_MOUSE - DNA polymerase eta OS=Mus musculus GN=Polh PE=1 SV=1	0.0	[1..713]	[1..694]
gi\|73973002 - gi\|73973002\|ref\|XP_532150.2\| PREDICTED: similar to polymerase (DNA directed), eta [Canis familiaris]	0.0	[1..713]	[1..712]
gi\|73587313, gi\|... - gi\|77735847\|ref\|NP_001029622.1\| DNA-directed DNA polymerase eta [Bos taurus], gi\|73587313\|gb\|AAI0339...	0.0	[1..713]	[1..711]
gi\|109485803, gi... - ref\|XP_236934.2\| similar to XPV [Rattus norvegicus], gi\|157817057\|ref\|NP_001101674.1\| DNA-directed D...	0.0	[1..713]	[1..689]
gi\|50838832, gi\|... - gi\|50838832\|ref\|NP_001001304.1\| DNA-directed DNA polymerase eta [Gallus gallus], gi\|31442180\|dbj\|BAC...	0.0	[1..703]	[1..673]

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Predicted Domain #1

Region A:
Residues: [1-450]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATGQDRVVA LVDMDCFFVQ VEQRQNPHLR NKPCAVVQYK SWKGGGIIAV SYEARAFGVT  60
   61 RSMWADDAKK LCPDLLLAQV RESRGKANLT KYREASVEVM EIMSRFAVIE RASIDEAYVD 120
  121 LTSAVQERLQ KLQGQPISAD LLPSTYIEGL PQGPTTAEET VQKEGMRKQG LFQWLDSLQI 180
  181 DNLTSPDLQL TVGAVIVEEM RAAIERETGF QCSAGISHNK VLAKLACGLN KPNRQTLVSH 240
  241 GSVPQLFSQM PIRKIRSLGG KLGASVIEIL GIEYMGELTQ FTESQLQSHF GEKNGSWLYA 300
  301 MCRGIEHDPV KPRQLPKTIG CSKNFPGKTA LATREQVQWW LLQLAQELEE RLTKDRNDND 360
  361 RVATQLVVSI RVQGDKRLSS LRRCCALTRY DAHKMSHDAF TVIKNCNTSG IQTEWSPPLT 420
  421 MLFLCATKFS ASAPSSSTDI TSFLSSDPSS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	89.69897
Match:	2oh2A
Description:	No description for 2oh2A was found.

Predicted Domain #2

Region A:
Residues: [451-589]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPKVPVTSSE AKTQGSGPAV TATKKATTSL ESFFQKAAER QKVKEASLSS LTAPTQAPMS  60
   61 NSPSKPSLPF QTSQSTGTEP FFKQKSLLLK QKQLNNSSVS SPQQNPWSNC KALPNSLPTE 120
  121 YPGCVPVCEG VSKLEESSK

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.11
Match:	2j63A
Description:	No description for 2j63A was found.

Predicted Domain #3

Region A:
Residues: [590-713]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATPAEMDLAH NSQSMHASSA SKSVLEVTQK ATPNPSLLAA EDQVPCEKCG SLVPVWDMPE  60
   61 HMDYHFALEL QKSFLQPHSS NPQVVSAVSH QGKRNPKSPL ACTNKRPRPE GMQTLESFFK 120
  121 PLTH

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits