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Protein Overview: FIG4

General Information:
Name(s) found: FIG4 [HGNC (HUGO)]
Description(s) found:
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  • gi|7662034|ref|NP_055660.1| Sac domain-containing inositol phosphatase 3 [Homo sapiens] [NCBI NR]
  • gi|57209326|emb|CAI42494.1| FIG4 homolog (S. cerevisiae) [Homo sapiens] [NCBI NR]
  • gi|56204498|emb|CAI19669.1| FIG4 homolog (S. cerevisiae) [Homo sapiens] [NCBI NR]
  • gi|27370598|gb|AAH41338.1| FIG4 homolog (S. cerevisiae) [Homo sapiens] [NCBI NR]
  • gi|2497367|sp|Q92562.1|FIG4_HUMAN RecName: Full=Polyphosphoinositide phosphatase; AltName: Full=Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; AltName: Full=SAC domain-containing protein 3 [NCBI NR]
  • gi|119568717|gb|EAW48332.1| KIAA0274 [Homo sapiens] [NCBI NR]
  • FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae) [HGNC (HUGO)]
  • SAC domain-containing protein 3 OS=Homo sapiens GN=FIG4 PE=1 SV=1 [Swiss-Prot]
  • (Q92562) Protein KIAA0274 [Swiss-Prot]
  • Polyphosphoinositide phosphatase OS=Homo sapiens GN=FIG4 PE=1 SV=1 [Swiss-Prot]
  • Hypothetical protein KIAA0274 [hmr_yeast5_DM3-1_pombe.fasta]
  • Sac domain-containing inositol phosphatase 3 [HMR_022704.fasta]
  • Sac domain-containing inositol phosphatase 3 [Homo sapiens]gi|27370598|gb|AAH41338.1| Sac domain-containing inositol phosphatase 3 [Homo sapiens]gi|2497367|sp|Q92562|K274_HUMAN Protein KIAA0274 [nrdb_11152004_Chlamydomonas]
  • SAC domain-containing protein 3 [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 SAC domain-containing protein 3 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_014845) KIAA0274 gene product; Sac domain-containing inositol phosphatase 3 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Sac domain-containing inositol phosphatase 3 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Protein KIAA0274 [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • SAC domain-containing protein 3 (FIG4 homolog) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • RP1-249I4.1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • FIG4 homolog (S. cerevisiae) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • KIAA0274 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 PROTEIN KIAA0274 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=FIG4 SAC domain-containing protein 3 [human-ipi-250309-contam.fasta]
  • IPI:IPI00022022.1|SWISS-PROT:Q92562|TREMBL:A8K6K6|ENSEMBL:ENSP00000230124|REFSEQ:NP_055660|H-INV:HIT000052543|VEGA:OTTHUMP00000016976 Tax_Id=9606 Gene_Symbol=FIG4 Polyphosphoinositide phosphatase [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=FIG4 SAC domain-containing protein 3 ENSG00000112367 IPI00022022 IPI00643340 IPI00552879 IPI00640096 IPI00643795 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=KIAA0274 SAC domain-containing protein 3 [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=FIG4 Polyphosphoinositide phosphatase [EBI-IPI_Human_3.71_03-24-2010_reversed.fasta]
  • polyphosphoinositide phosphatase [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q92562;Q53H49;Q5TCS6; RecName: Full=Polyphosphoinositide phosphatase; AltName: Full=Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; AltName: Full=SAC domain-containing protein 3; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Polyphosphoinositide phosphatase OS=Homo sapiens GN=FIG4 [011711_HMR.fasta]
  • GeneSymbol=FIG4 Synonyms=ALS11|CMT4J|KIAA0274|SAC3|dJ249I4.1 polyphosphoinositide phosphatase [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Polyphosphoinositide phosphatase GN=FIG4 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 907 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTAAAPIIS SVQKLVLYET RARYFLVGSN NAETKYRVLK IDRTEPKDLV IIDDRHVYTQ  60
   61 QEVRELLGRL DLGNRTKMGQ KGSSGLFRAV SAFGVVGFVR FLEGYYIVLI TKRRKMADIG 120
  121 GHAIYKVEDT NMIYIPNDSV RVTHPDEARY LRIFQNVDLS SNFYFSYSYD LSHSLQYNLT 180
  181 VLRMPLEMLK SEMTQNRQES FDIFEDEGLI TQGGSGVFGI CSEPYMKYVW NGELLDIIKS 240
  241 TVHRDWLLYI IHGFCGQSKL LIYGRPVYVT LIARRSSKFA GTRFLKRGAN CEGDVANEVE 300
  301 TEQILCDASV MSFTAGSYSS YVQVRGSVPL YWSQDISTMM PKPPITLDQA DPFAHVAALH 360
  361 FDQMFQRFGS PIIILNLVKE REKRKHERIL SEELVAAVTY LNQFLPPEHT IVYIPWDMAK 420
  421 YTKSKLCNVL DRLNVIAESV VKKTGFFVNR PDSYCSILRP DEKWNELGGC VIPTGRLQTG 480
  481 ILRTNCVDCL DRTNTAQFMV GKCALAYQLY SLGLIDKPNL QFDTDAVRLF EELYEDHGDT 540
  541 LSLQYGGSQL VHRVKTYRKI APWTQHSKDI MQTLSRYYSN AFSDADRQDS INLFLGVFHP 600
  601 TEGKPHLWEL PTDFYLHHKN TMRLLPTRRS YTYWWTPEVI KHLPLPYDEV ICAVNLKKLI 660
  661 VKKFHKYEEE IDIHNEFFRP YELSSFDDTF CLAMTSSARD FMPKTVGIDP SPFTVRKPDE 720
  721 TGKSVLGNKS NREEAVLQRK TAASAPPPPS EEAVSSSSED DSGTDREEEG SVSQRSTPVK 780
  781 MTDAGDSAKV TENVVQPMKE LYGINLSDGL SEEDFSIYSR FVQLGQSQHK QDKNSQQPCS 840
  841 RCSDGVIKLT PISAFSQDNI YEVQPPRVDR KSTEIFQAHI QASQGIMQPL GKEDSSMYRE 900
  901 YIRNRYL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..89] MSA 1.155995 View MSA. No confident structure predictions are available.
    2 View Details [90..176] MSA 3.183989 View MSA. No confident structure predictions are available.
    3 View Details [177..370] MSA 2.192996 View MSA. No confident structure predictions are available.
    4 View Details [371..515] MSA 1.189984 View MSA. No confident structure predictions are available.
    5 View Details [516..595] MSA 3.188979 View MSA. Confident ab initio structure predictions are available.
    6 View Details [596..683] PSI-BLAST 5.154902 Synaptojanin, IPP5C domain
    7 View Details [684..806] MSA 1.051974 View MSA. No confident structure predictions are available.
    8 View Details [807..907] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.61

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle