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View Structure Prediction Details

Protein: FIG4
Organism: Homo sapiens
Length: 907 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FIG4.

Description E-value Query
Range
Subject
Range
gi|110225894, gi... - gi|149027752|gb|EDL83246.1| rCG38206, isoform CRA_b [Rattus norvegicus], gi|114052238|ref|NP_0010405...
0.0 [1..907] [1..907]
gi|73973735, gi|... - gi|73973735|ref|XP_532259.2| PREDICTED: similar to SAC domain-containing protein 3 isoform 1 [Canis ...
0.0 [1..907] [1..907]
gi|62897023 - gi|62897023|dbj|BAD96452.1| Sac domain-containing inositol phosphatase 3 variant [Homo sapiens]
0.0 [1..907] [1..907]
gi|167830421, gi... - gi|167830421|ref|NP_001108096.1| FIG4 homolog [Pan troglodytes], gi|114608993|ref|XP_518683.2| PREDI...
0.0 [8..907] [95..994]
FIG4_MOUSE - Polyphosphoinositide phosphatase OS=Mus musculus GN=Fig4 PE=1 SV=1
0.0 [1..907] [1..907]
gi|92096743, gi|... - gi|92096743|gb|AAI14695.1| FIG4 homolog (S. cerevisiae) [Bos taurus], gi|115496568|ref|NP_001069482....
0.0 [1..907] [1..907]
gi|50744596 - gi|50744596|ref|XP_419792.1| PREDICTED: similar to Protein KIAA0274 [Gallus gallus]
0.0 [23..907] [20..921]

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Predicted Domain #1
Region A:
Residues: [1-89]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTAAAPIIS SVQKLVLYET RARYFLVGSN NAETKYRVLK IDRTEPKDLV IIDDRHVYTQ  60
   61 QEVRELLGRL DLGNRTKMGQ KGSSGLFRA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [90-176]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSAFGVVGFV RFLEGYYIVL ITKRRKMADI GGHAIYKVED TNMIYIPNDS VRVTHPDEAR  60
   61 YLRIFQNVDL SSNFYFSYSY DLSHSLQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [177-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YNLTVLRMPL EMLKSEMTQN RQESFDIFED EGLITQGGSG VFGICSEPYM KYVWNGELLD  60
   61 IIKSTVHRDW LLYIIHGFCG QSKLLIYGRP VYVTLIARRS SKFAGTRFLK RGANCEGDVA 120
  121 NEVETEQILC DASVMSFTAG SYSSYVQVRG SVPLYWSQDI STMMPKPPIT LDQADPFAHV 180
  181 AALHFDQMFQ RFGS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [371-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PIIILNLVKE REKRKHERIL SEELVAAVTY LNQFLPPEHT IVYIPWDMAK YTKSKLCNVL  60
   61 DRLNVIAESV VKKTGFFVNR PDSYCSILRP DEKWNELGGC VIPTGRLQTG ILRTNCVDCL 120
  121 DRTNTAQFMV GKCALAYQLY SLGLI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [516-595]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKPNLQFDTD AVRLFEELYE DHGDTLSLQY GGSQLVHRVK TYRKIAPWTQ HSKDIMQTLS  60
   61 RYYSNAFSDA DRQDSINLFL 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.825 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac

Predicted Domain #6
Region A:
Residues: [596-683]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVFHPTEGKP HLWELPTDFY LHHKNTMRLL PTRRSYTYWW TPEVIKHLPL PYDEVICAVN  60
   61 LKKLIVKKFH KYEEEIDIHN EFFRPYEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.154902
Match: 1i9yA
Description: Synaptojanin, IPP5C domain
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [684-806]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSFDDTFCLA MTSSARDFMP KTVGIDPSPF TVRKPDETGK SVLGNKSNRE EAVLQRKTAA  60
   61 SAPPPPSEEA VSSSSEDDSG TDREEEGSVS QRSTPVKMTD AGDSAKVTEN VVQPMKELYG 120
  121 INL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [807-907]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDGLSEEDFS IYSRFVQLGQ SQHKQDKNSQ QPCSRCSDGV IKLTPISAFS QDNIYEVQPP  60
   61 RVDRKSTEIF QAHIQASQGI MQPLGKEDSS MYREYIRNRY L

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle